FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214085480> ?p ?o ?g. }

• W3214085480 endingPage "19" @default.
• W3214085480 startingPage "1" @default.
• W3214085480 abstract "Breast cancer is one of the most common malignancies in women worldwide. Traditional Chinese medicine has been used as adjunctive or complementary therapy for breast cancer. Diterpenoids from Euphorbia fischeriana Steud. have been demonstrated to possess anti-breast-cancer activity. This research was aimed to systematically explore the diterpenoids from E. fischeriana and study the multiple mechanisms on breast cancer. The structures of diterpenoids were identified by the integrated strategy of UHPLC-Q-TOF-MS and molecular networking. A total of 177 diterpenoids belonging to 13 types were collected. In silico ADME analysis was performed on these compounds. It indicated that 130 of 177 diterpenoids completely adjusted to Lipinski's rule. The targets of compounds were obtained from PharmMapper. The targets of breast cancer were collected from GeneCards. Then, 197 compounds-related targets and 544 breast cancer-related targets were identified. After the intersection process, 58 overlapping targets between compounds-related targets and breast cancer-related targets were acquired. The STRING database was applied to predict the protein-protein interactions. The GO and KEGG pathway enrichment analysis were performed by using the KOBAS database. It indicated that these predicted pathways were closely related to breast cancer. The treatment effect of E. fischeriana on breast cancer might be performed through signaling pathways, such as IL-17 signaling pathway, MAPK signaling pathway, and PI3K-Akt signaling pathway. The predicted top genes such as EGFR, ESR, MAPK, SRC, CASP3, CDK2, and KDR were involved in cell proliferation, gene transcription, apoptosis, signal transduction, DNA damage and repair, tumor differentiation, metastasis, and cell cycle, which indicated that E. fischeriana might treat breast cancer comprehensively. A compounds-KEGG pathways-related targets network was built by using cytoHubba to analyze the hub compounds and targets. It concluded that E. fischeriana treated breast cancer not only by the main components but also by the microconstituents, which reflected the overall regulatory role of multicomponents treating breast cancer. To estimate the binding affinities, binding sites, and binding postures, molecular docking simulations between 177 diterpenoids and top 19 targets were carried out. The results are basically in line with expectations. In conclusion, these results can serve as references for researchers studying potential targets of diterpenoids from E. fischeriana on breast cancer in the future." @default.
• W3214085480 created "2021-11-22" @default.
• W3214085480 creator A5007126456 @default.
• W3214085480 creator A5015228968 @default.
• W3214085480 creator A5020147975 @default.
• W3214085480 creator A5029358627 @default.
• W3214085480 creator A5058502781 @default.
• W3214085480 creator A5060695578 @default.
• W3214085480 creator A5088126310 @default.
• W3214085480 creator A5088267604 @default.
• W3214085480 date "2021-11-11" @default.
• W3214085480 modified "2023-10-16" @default.
• W3214085480 title "Integrated Strategy of UHPLC-Q-TOF-MS and Molecular Networking for Identification of Diterpenoids from Euphorbia fischeriana Steud. and Prediction of the Anti-Breast-Cancer Mechanism by the Network Pharmacological Method" @default.
• W3214085480 cites W1556792164 @default.
• W3214085480 cites W1965876149 @default.
• W3214085480 cites W1987520879 @default.
• W3214085480 cites W2000170468 @default.
• W3214085480 cites W2049465709 @default.
• W3214085480 cites W2049639806 @default.
• W3214085480 cites W2051751364 @default.
• W3214085480 cites W2058306389 @default.
• W3214085480 cites W2059682051 @default.
• W3214085480 cites W2080366118 @default.
• W3214085480 cites W2103017472 @default.
• W3214085480 cites W2103912979 @default.
• W3214085480 cites W2110065044 @default.
• W3214085480 cites W2111117723 @default.
• W3214085480 cites W2113474313 @default.
• W3214085480 cites W2128281235 @default.
• W3214085480 cites W2144656637 @default.
• W3214085480 cites W2159675211 @default.
• W3214085480 cites W2165337892 @default.
• W3214085480 cites W2172347205 @default.
• W3214085480 cites W2212408818 @default.
• W3214085480 cites W2238836231 @default.
• W3214085480 cites W2287845648 @default.
• W3214085480 cites W2305446997 @default.
• W3214085480 cites W2320841243 @default.
• W3214085480 cites W2333759720 @default.
• W3214085480 cites W2419100559 @default.
• W3214085480 cites W2474747771 @default.
• W3214085480 cites W2504691963 @default.
• W3214085480 cites W2552188553 @default.
• W3214085480 cites W2582063619 @default.
• W3214085480 cites W2584150242 @default.
• W3214085480 cites W2605290106 @default.
• W3214085480 cites W2611425558 @default.
• W3214085480 cites W2733455685 @default.
• W3214085480 cites W2754962193 @default.
• W3214085480 cites W2757187034 @default.
• W3214085480 cites W2792190800 @default.
• W3214085480 cites W2800901381 @default.
• W3214085480 cites W2801209532 @default.
• W3214085480 cites W2899713737 @default.
• W3214085480 cites W2900569176 @default.
• W3214085480 cites W2911703425 @default.
• W3214085480 cites W2914466706 @default.
• W3214085480 cites W2937407149 @default.
• W3214085480 cites W2945656536 @default.
• W3214085480 cites W2947725630 @default.
• W3214085480 cites W2952421590 @default.
• W3214085480 cites W2953543467 @default.
• W3214085480 cites W2960032923 @default.
• W3214085480 cites W2981989748 @default.
• W3214085480 cites W2995204555 @default.
• W3214085480 cites W3034606924 @default.
• W3214085480 cites W3036904754 @default.
• W3214085480 cites W3081515091 @default.
• W3214085480 cites W3083275704 @default.
• W3214085480 cites W3097266838 @default.
• W3214085480 cites W3107770127 @default.
• W3214085480 cites W3110859844 @default.
• W3214085480 cites W3115350018 @default.
• W3214085480 cites W3127941347 @default.
• W3214085480 cites W3145991282 @default.
• W3214085480 doi "https://doi.org/10.1155/2021/3829434" @default.
• W3214085480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8601799" @default.
• W3214085480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34804177" @default.
• W3214085480 hasPublicationYear "2021" @default.
• W3214085480 type Work @default.
• W3214085480 sameAs 3214085480 @default.
• W3214085480 citedByCount "1" @default.
• W3214085480 countsByYear W32140854802022 @default.
• W3214085480 crossrefType "journal-article" @default.
• W3214085480 hasAuthorship W3214085480A5007126456 @default.
• W3214085480 hasAuthorship W3214085480A5015228968 @default.
• W3214085480 hasAuthorship W3214085480A5020147975 @default.
• W3214085480 hasAuthorship W3214085480A5029358627 @default.
• W3214085480 hasAuthorship W3214085480A5058502781 @default.
• W3214085480 hasAuthorship W3214085480A5060695578 @default.
• W3214085480 hasAuthorship W3214085480A5088126310 @default.
• W3214085480 hasAuthorship W3214085480A5088267604 @default.
• W3214085480 hasBestOaLocation W32140854801 @default.
• W3214085480 hasConcept C104317684 @default.
• W3214085480 hasConcept C121608353 @default.
• W3214085480 hasConcept C150194340 @default.
• W3214085480 hasConcept C152724338 @default.
• W3214085480 hasConcept C162317418 @default.

• next