FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214095917> ?p ?o ?g. }

• W3214095917 endingPage "102" @default.
• W3214095917 startingPage "97" @default.
• W3214095917 abstract "The T indotineae population shows a high amount of terbinafine resistant isolates based on different point mutations of squalene epoxidase erg1 (ergosterol) gene. A significant proportion of these isolates also show azole resistance.Elucidation of the molecular mechanism for azole resistance, especially the identification of mutations in the sterol 14-α demethylase Erg11 genes, which encode for enzymes interacting with azoles.Sequencing of putative Erg11 genes and analysis of phenotypic resistance pattern using a microplate-laser-nephelometry-based growth assay.Four different types of Erg11B mutants were detected; two double mutants with Ala230Thr/Asp441Gly, respectively, Ala230/Tyr444His and single mutants with Gly443Glu, Tyr444Cys and Tyr444His. All isolates featured the wild type genotype of Erg11A. All strains demonstrated different combinations of Erg1 and Erg11 genotypes.Resistance against terbinafine and azoles developed several times independently within the T indotineae population. The challenge for fungal treatment is, therefore, that species identification is not enough for prediction of therapeutic efficacy of antifungals. In the future, it will also become important to analyse genes involved in resistance mechanisms." @default.
• W3214095917 created "2021-11-22" @default.
• W3214095917 creator A5018812407 @default.
• W3214095917 creator A5034101869 @default.
• W3214095917 creator A5034753927 @default.
• W3214095917 creator A5034989348 @default.
• W3214095917 date "2021-11-16" @default.
• W3214095917 modified "2023-10-14" @default.
• W3214095917 title "Point mutations in the squalene epoxidase <i>erg1</i> and sterol 14‐α demethylase <i>erg11</i> gene of <i>T indotineae</i> isolates indicate that the resistant mutant strains evolved independently" @default.
• W3214095917 cites W2102332954 @default.
• W3214095917 cites W2108313755 @default.
• W3214095917 cites W2129937209 @default.
• W3214095917 cites W2142627320 @default.
• W3214095917 cites W2153283265 @default.
• W3214095917 cites W2225884786 @default.
• W3214095917 cites W2328396711 @default.
• W3214095917 cites W2501204655 @default.
• W3214095917 cites W2790695048 @default.
• W3214095917 cites W2790795010 @default.
• W3214095917 cites W2803962697 @default.
• W3214095917 cites W2904454825 @default.
• W3214095917 cites W2904645990 @default.
• W3214095917 cites W2946487071 @default.
• W3214095917 cites W2971623181 @default.
• W3214095917 cites W2973671521 @default.
• W3214095917 cites W3011204877 @default.
• W3214095917 cites W3016752752 @default.
• W3214095917 cites W3046034096 @default.
• W3214095917 cites W3090329576 @default.
• W3214095917 cites W3116171444 @default.
• W3214095917 cites W3155643501 @default.
• W3214095917 cites W4294216483 @default.
• W3214095917 doi "https://doi.org/10.1111/myc.13393" @default.
• W3214095917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34767653" @default.
• W3214095917 hasPublicationYear "2021" @default.
• W3214095917 type Work @default.
• W3214095917 sameAs 3214095917 @default.
• W3214095917 citedByCount "16" @default.
• W3214095917 countsByYear W32140959172022 @default.
• W3214095917 countsByYear W32140959172023 @default.
• W3214095917 crossrefType "journal-article" @default.
• W3214095917 hasAuthorship W3214095917A5018812407 @default.
• W3214095917 hasAuthorship W3214095917A5034101869 @default.
• W3214095917 hasAuthorship W3214095917A5034753927 @default.
• W3214095917 hasAuthorship W3214095917A5034989348 @default.
• W3214095917 hasBestOaLocation W32140959171 @default.
• W3214095917 hasConcept C104317684 @default.
• W3214095917 hasConcept C143065580 @default.
• W3214095917 hasConcept C2776703722 @default.
• W3214095917 hasConcept C2777071850 @default.
• W3214095917 hasConcept C2777910421 @default.
• W3214095917 hasConcept C2778163477 @default.
• W3214095917 hasConcept C2778236110 @default.
• W3214095917 hasConcept C2778718757 @default.
• W3214095917 hasConcept C2779548794 @default.
• W3214095917 hasConcept C2780315139 @default.
• W3214095917 hasConcept C2781364455 @default.
• W3214095917 hasConcept C2908647359 @default.
• W3214095917 hasConcept C41091548 @default.
• W3214095917 hasConcept C54355233 @default.
• W3214095917 hasConcept C553450214 @default.
• W3214095917 hasConcept C55493867 @default.
• W3214095917 hasConcept C71924100 @default.
• W3214095917 hasConcept C85411794 @default.
• W3214095917 hasConcept C86803240 @default.
• W3214095917 hasConcept C89423630 @default.
• W3214095917 hasConcept C99454951 @default.
• W3214095917 hasConceptScore W3214095917C104317684 @default.
• W3214095917 hasConceptScore W3214095917C143065580 @default.
• W3214095917 hasConceptScore W3214095917C2776703722 @default.
• W3214095917 hasConceptScore W3214095917C2777071850 @default.
• W3214095917 hasConceptScore W3214095917C2777910421 @default.
• W3214095917 hasConceptScore W3214095917C2778163477 @default.
• W3214095917 hasConceptScore W3214095917C2778236110 @default.
• W3214095917 hasConceptScore W3214095917C2778718757 @default.
• W3214095917 hasConceptScore W3214095917C2779548794 @default.
• W3214095917 hasConceptScore W3214095917C2780315139 @default.
• W3214095917 hasConceptScore W3214095917C2781364455 @default.
• W3214095917 hasConceptScore W3214095917C2908647359 @default.
• W3214095917 hasConceptScore W3214095917C41091548 @default.
• W3214095917 hasConceptScore W3214095917C54355233 @default.
• W3214095917 hasConceptScore W3214095917C553450214 @default.
• W3214095917 hasConceptScore W3214095917C55493867 @default.
• W3214095917 hasConceptScore W3214095917C71924100 @default.
• W3214095917 hasConceptScore W3214095917C85411794 @default.
• W3214095917 hasConceptScore W3214095917C86803240 @default.
• W3214095917 hasConceptScore W3214095917C89423630 @default.
• W3214095917 hasConceptScore W3214095917C99454951 @default.
• W3214095917 hasFunder F4320324588 @default.
• W3214095917 hasIssue "1" @default.
• W3214095917 hasLocation W32140959171 @default.
• W3214095917 hasLocation W32140959172 @default.
• W3214095917 hasOpenAccess W3214095917 @default.
• W3214095917 hasPrimaryLocation W32140959171 @default.
• W3214095917 hasRelatedWork W1648080802 @default.
• W3214095917 hasRelatedWork W2002433481 @default.
• W3214095917 hasRelatedWork W2027696912 @default.
• W3214095917 hasRelatedWork W2059514697 @default.

• next