Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214097666> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3214097666 endingPage "e000788" @default.
- W3214097666 startingPage "e000788" @default.
- W3214097666 abstract "Infliximab is an efficacious therapy for inflammatory bowel disease and may play a role in management of some extraintestinal manifestations. While higher trough levels of infliximab are associated with higher rates of disease remission, the association between trough levels of infliximab and arthralgia activity characterised as an extraintestinal manifestation has yet to be defined.We aimed to assess the association between serum trough levels of infliximab and peripheral arthralgia activity in patients with inflammatory bowel disease.In this cross-sectional study, we identified patients with inflammatory bowel disease on infliximab therapy with known history of arthralgias attributed to an extraintestinal manifestation. Collected variables included disease phenotype, medications (such as thiopurines or methotrexate), Harvey Bradshaw Index, partial Mayo score, C reactive protein, trough levels of infliximab and anti-infliximab antibodies. The primary outcome was active patient-reported arthralgia.Out of 267 patients included, 65 (24.4%) had active arthralgias at the time the trough level of infliximab was measured. No significant differences in trough levels were seen between those patients with and without arthralgias. Patients on combination therapy with methotrexate or thiopurines or those with detectable anti-infliximab antibodies were not more likely to have inactive arthralgias (OR 0.99, 95% CI 0.57 to 1.74, p=0.99 and OR 1.94, 95% CI 0.9 to 4.1, p=0.09, respectively).This study suggests that although therapeutic drug monitoring of infliximab can have a role in the management of Crohn's disease and ulcerative colitis, it does not seem to be useful in managing arthralgias associated with inflammatory bowel disease." @default.
- W3214097666 created "2021-11-22" @default.
- W3214097666 creator A5033336413 @default.
- W3214097666 creator A5034738993 @default.
- W3214097666 creator A5044344718 @default.
- W3214097666 creator A5077611890 @default.
- W3214097666 creator A5079194701 @default.
- W3214097666 creator A5085380044 @default.
- W3214097666 creator A5088181354 @default.
- W3214097666 date "2021-11-01" @default.
- W3214097666 modified "2023-10-14" @default.
- W3214097666 title "Serum trough levels of infliximab are not associated with peripheral arthralgia activity in patients with inflammatory bowel disease" @default.
- W3214097666 cites W1923174004 @default.
- W3214097666 cites W1968262103 @default.
- W3214097666 cites W2003904406 @default.
- W3214097666 cites W2013201041 @default.
- W3214097666 cites W2015629841 @default.
- W3214097666 cites W2025032284 @default.
- W3214097666 cites W2026437676 @default.
- W3214097666 cites W2040234205 @default.
- W3214097666 cites W2054001385 @default.
- W3214097666 cites W2056770557 @default.
- W3214097666 cites W2073068909 @default.
- W3214097666 cites W2088135039 @default.
- W3214097666 cites W2095104608 @default.
- W3214097666 cites W2140536646 @default.
- W3214097666 cites W2180305266 @default.
- W3214097666 cites W2418057816 @default.
- W3214097666 cites W2744879509 @default.
- W3214097666 cites W3017270591 @default.
- W3214097666 doi "https://doi.org/10.1136/bmjgast-2021-000788" @default.
- W3214097666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8587383" @default.
- W3214097666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34764142" @default.
- W3214097666 hasPublicationYear "2021" @default.
- W3214097666 type Work @default.
- W3214097666 sameAs 3214097666 @default.
- W3214097666 citedByCount "0" @default.
- W3214097666 crossrefType "journal-article" @default.
- W3214097666 hasAuthorship W3214097666A5033336413 @default.
- W3214097666 hasAuthorship W3214097666A5034738993 @default.
- W3214097666 hasAuthorship W3214097666A5044344718 @default.
- W3214097666 hasAuthorship W3214097666A5077611890 @default.
- W3214097666 hasAuthorship W3214097666A5079194701 @default.
- W3214097666 hasAuthorship W3214097666A5085380044 @default.
- W3214097666 hasAuthorship W3214097666A5088181354 @default.
- W3214097666 hasBestOaLocation W32140976661 @default.
- W3214097666 hasConcept C126322002 @default.
- W3214097666 hasConcept C203014093 @default.
- W3214097666 hasConcept C2777138892 @default.
- W3214097666 hasConcept C2778260677 @default.
- W3214097666 hasConcept C2779134260 @default.
- W3214097666 hasConcept C2780479503 @default.
- W3214097666 hasConcept C2781059491 @default.
- W3214097666 hasConcept C2909675724 @default.
- W3214097666 hasConcept C2911091166 @default.
- W3214097666 hasConcept C31785415 @default.
- W3214097666 hasConcept C71924100 @default.
- W3214097666 hasConcept C90924648 @default.
- W3214097666 hasConceptScore W3214097666C126322002 @default.
- W3214097666 hasConceptScore W3214097666C203014093 @default.
- W3214097666 hasConceptScore W3214097666C2777138892 @default.
- W3214097666 hasConceptScore W3214097666C2778260677 @default.
- W3214097666 hasConceptScore W3214097666C2779134260 @default.
- W3214097666 hasConceptScore W3214097666C2780479503 @default.
- W3214097666 hasConceptScore W3214097666C2781059491 @default.
- W3214097666 hasConceptScore W3214097666C2909675724 @default.
- W3214097666 hasConceptScore W3214097666C2911091166 @default.
- W3214097666 hasConceptScore W3214097666C31785415 @default.
- W3214097666 hasConceptScore W3214097666C71924100 @default.
- W3214097666 hasConceptScore W3214097666C90924648 @default.
- W3214097666 hasIssue "1" @default.
- W3214097666 hasLocation W32140976661 @default.
- W3214097666 hasLocation W32140976662 @default.
- W3214097666 hasLocation W32140976663 @default.
- W3214097666 hasOpenAccess W3214097666 @default.
- W3214097666 hasPrimaryLocation W32140976661 @default.
- W3214097666 hasRelatedWork W1968760412 @default.
- W3214097666 hasRelatedWork W2014462309 @default.
- W3214097666 hasRelatedWork W2064877889 @default.
- W3214097666 hasRelatedWork W2069883074 @default.
- W3214097666 hasRelatedWork W2086360535 @default.
- W3214097666 hasRelatedWork W2089392787 @default.
- W3214097666 hasRelatedWork W2576474053 @default.
- W3214097666 hasRelatedWork W3022383156 @default.
- W3214097666 hasRelatedWork W3151514357 @default.
- W3214097666 hasRelatedWork W2978685749 @default.
- W3214097666 hasVolume "8" @default.
- W3214097666 isParatext "false" @default.
- W3214097666 isRetracted "false" @default.
- W3214097666 magId "3214097666" @default.
- W3214097666 workType "article" @default.