FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214098375> ?p ?o ?g. }

• W3214098375 endingPage "109241" @default.
• W3214098375 startingPage "109241" @default.
• W3214098375 abstract "The present study aimed to explore the toxic effects of excessive dietary Mn in livers and cerebrums of Jianzhou Da'er goat (Capra hircus). Three-month old goats were assigned into three groups: control group, fed on basal diet; Mn I group, fed on the basal diet mixed with MnCl2 (2.5 g/kg); Mn II group, fed on the basal diet mixed with MnCl2 (5 g/kg). Compared with the control group, the activities of serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and the concentrations of interferon-γ (IFN-γ) in Mn I and Mn II groups were significantly increased, but the concentrations of IgG in Mn I and Mn II groups were significantly decreased (p < 0.05). The activities of superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px), and the concentrations of glutathione (GSH) in Mn I and Mn II groups were significantly decreased, whereas the concentrations of malondialdehyde (MDA) in Mn I and Mn II groups were significantly increased in livers and cerebrums (p < 0.05). Moreover, the hepatocytes necrosed, inflammatory cells infiltrated, chromatin concentrated, mitochondrial cristae reduced in Mn I and Mn II groups. The nerve cells necrosed, blood vessels congested, inflammatory cells infiltrated, mitochondrial electron density and mitochondrial cristae decreased, and vacuolization increased in Mn I and Mn II groups. Furthermore, the mRNA expressions of tumor necrosis factor alpha (TNF-α), tumor necrosis factor receptor type 1 (TNFR1), fas-associated protein via a death domain (FADD), Bcl2-associated X (Bax), cysteinyl aspartate specific proteinase 3, 8, 9 (Caspase-3, 8, 9) in Mn I and Mn II groups were significantly increased (p < 0.05), but the mRNA expressions of B-cell lymphoma-2 (Bcl-2) in Mn I and Mn II groups were significantly decreased (p < 0.05) in livers. The mRNA expressions of Bcl-2, Bax, Caspase-3, 9, 7, 12 in Mn I and Mn II groups were significantly increased (p < 0.05), however, the ratio of Bcl-2/Bax in Mn I and Mn II groups was significantly decreased (p < 0.05) in cerebrums. In summary, our results provided new insights for better understanding the mechanisms of Mn toxicity in Capra hircus." @default.
• W3214098375 created "2021-11-22" @default.
• W3214098375 creator A5012278873 @default.
• W3214098375 creator A5014182743 @default.
• W3214098375 creator A5042591556 @default.
• W3214098375 creator A5048019384 @default.
• W3214098375 creator A5056450584 @default.
• W3214098375 date "2022-02-01" @default.
• W3214098375 modified "2023-09-22" @default.
• W3214098375 title "Excessive manganese alters serum biochemical indices, induces histopathological alterations, and activates apoptosis in liver and cerebrum of Jianzhou Da'er goat (Capra hircus)" @default.
• W3214098375 cites W1966634405 @default.
• W3214098375 cites W1968435064 @default.
• W3214098375 cites W1968889405 @default.
• W3214098375 cites W1993129579 @default.
• W3214098375 cites W1997061704 @default.
• W3214098375 cites W2009132341 @default.
• W3214098375 cites W2028662420 @default.
• W3214098375 cites W2042224366 @default.
• W3214098375 cites W2045175932 @default.
• W3214098375 cites W2077735344 @default.
• W3214098375 cites W2082606501 @default.
• W3214098375 cites W2085828899 @default.
• W3214098375 cites W2108307486 @default.
• W3214098375 cites W2117821054 @default.
• W3214098375 cites W2145294892 @default.
• W3214098375 cites W2262022772 @default.
• W3214098375 cites W2316062179 @default.
• W3214098375 cites W2340606132 @default.
• W3214098375 cites W2381940071 @default.
• W3214098375 cites W2540231449 @default.
• W3214098375 cites W2545623698 @default.
• W3214098375 cites W2565850482 @default.
• W3214098375 cites W2590618391 @default.
• W3214098375 cites W2600375283 @default.
• W3214098375 cites W2727463302 @default.
• W3214098375 cites W2739139273 @default.
• W3214098375 cites W2746587895 @default.
• W3214098375 cites W2752562225 @default.
• W3214098375 cites W2767477318 @default.
• W3214098375 cites W2773580564 @default.
• W3214098375 cites W2790226313 @default.
• W3214098375 cites W2790332118 @default.
• W3214098375 cites W2795787434 @default.
• W3214098375 cites W2895481993 @default.
• W3214098375 cites W2919558391 @default.
• W3214098375 cites W2937109018 @default.
• W3214098375 cites W2972703194 @default.
• W3214098375 cites W3000200820 @default.
• W3214098375 cites W3006810029 @default.
• W3214098375 cites W3091162156 @default.
• W3214098375 cites W3092236242 @default.
• W3214098375 cites W3102384189 @default.
• W3214098375 cites W3135050028 @default.
• W3214098375 cites W3135135728 @default.
• W3214098375 cites W3156850148 @default.
• W3214098375 cites W3165690239 @default.
• W3214098375 cites W3165713447 @default.
• W3214098375 cites W839847231 @default.
• W3214098375 doi "https://doi.org/10.1016/j.cbpc.2021.109241" @default.
• W3214098375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34752896" @default.
• W3214098375 hasPublicationYear "2022" @default.
• W3214098375 type Work @default.
• W3214098375 sameAs 3214098375 @default.
• W3214098375 citedByCount "2" @default.
• W3214098375 countsByYear W32140983752022 @default.
• W3214098375 countsByYear W32140983752023 @default.
• W3214098375 crossrefType "journal-article" @default.
• W3214098375 hasAuthorship W3214098375A5012278873 @default.
• W3214098375 hasAuthorship W3214098375A5014182743 @default.
• W3214098375 hasAuthorship W3214098375A5042591556 @default.
• W3214098375 hasAuthorship W3214098375A5048019384 @default.
• W3214098375 hasAuthorship W3214098375A5056450584 @default.
• W3214098375 hasConcept C126322002 @default.
• W3214098375 hasConcept C134018914 @default.
• W3214098375 hasConcept C160160445 @default.
• W3214098375 hasConcept C181199279 @default.
• W3214098375 hasConcept C185592680 @default.
• W3214098375 hasConcept C190283241 @default.
• W3214098375 hasConcept C2775838275 @default.
• W3214098375 hasConcept C2776151105 @default.
• W3214098375 hasConcept C2778401633 @default.
• W3214098375 hasConcept C2778760513 @default.
• W3214098375 hasConcept C538909803 @default.
• W3214098375 hasConcept C55493867 @default.
• W3214098375 hasConcept C71924100 @default.
• W3214098375 hasConcept C86803240 @default.
• W3214098375 hasConceptScore W3214098375C126322002 @default.
• W3214098375 hasConceptScore W3214098375C134018914 @default.
• W3214098375 hasConceptScore W3214098375C160160445 @default.
• W3214098375 hasConceptScore W3214098375C181199279 @default.
• W3214098375 hasConceptScore W3214098375C185592680 @default.
• W3214098375 hasConceptScore W3214098375C190283241 @default.
• W3214098375 hasConceptScore W3214098375C2775838275 @default.
• W3214098375 hasConceptScore W3214098375C2776151105 @default.
• W3214098375 hasConceptScore W3214098375C2778401633 @default.
• W3214098375 hasConceptScore W3214098375C2778760513 @default.
• W3214098375 hasConceptScore W3214098375C538909803 @default.
• W3214098375 hasConceptScore W3214098375C55493867 @default.

• next