Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214132407> ?p ?o ?g. }
- W3214132407 endingPage "1785" @default.
- W3214132407 startingPage "1785" @default.
- W3214132407 abstract "Coenzyme Q is a unique lipidic molecule highly conserved in evolution and essential to maintaining aerobic metabolism. It is endogenously synthesized in all cells by a very complex pathway involving a group of nuclear genes that share high homology among species. This pathway is tightly regulated at transcription and translation, but also by environment and energy requirements. Here, we review how coenzyme Q reacts within mitochondria to promote ATP synthesis and also integrates a plethora of metabolic pathways and regulates mitochondrial oxidative stress. Coenzyme Q is also located in all cellular membranes and plasma lipoproteins in which it exerts antioxidant function, and its reaction with different extramitochondrial oxidoreductases contributes to regulate the cellular redox homeostasis and cytosolic oxidative stress, providing a key factor in controlling various apoptosis mechanisms. Coenzyme Q levels can be decreased in humans by defects in the biosynthesis pathway or by mitochondrial or cytosolic dysfunctions, leading to a highly heterogeneous group of mitochondrial diseases included in the coenzyme Q deficiency syndrome. We also review the importance of coenzyme Q levels and its reactions involved in aging and age-associated metabolic disorders, and how the strategy of its supplementation has had benefits for combating these diseases and for physical performance in aging." @default.
- W3214132407 created "2021-11-22" @default.
- W3214132407 creator A5014289292 @default.
- W3214132407 creator A5058533673 @default.
- W3214132407 creator A5069371367 @default.
- W3214132407 creator A5069949049 @default.
- W3214132407 creator A5080315972 @default.
- W3214132407 date "2021-11-08" @default.
- W3214132407 modified "2023-10-03" @default.
- W3214132407 title "Coenzyme Q at the Hinge of Health and Metabolic Diseases" @default.
- W3214132407 cites W1193855731 @default.
- W3214132407 cites W1491763803 @default.
- W3214132407 cites W1520568691 @default.
- W3214132407 cites W1534973403 @default.
- W3214132407 cites W1823885789 @default.
- W3214132407 cites W1899652908 @default.
- W3214132407 cites W1909953453 @default.
- W3214132407 cites W1962470662 @default.
- W3214132407 cites W1964077809 @default.
- W3214132407 cites W1965285497 @default.
- W3214132407 cites W1967433085 @default.
- W3214132407 cites W1968882091 @default.
- W3214132407 cites W1971714188 @default.
- W3214132407 cites W1972582734 @default.
- W3214132407 cites W1974453334 @default.
- W3214132407 cites W1979088319 @default.
- W3214132407 cites W1981554905 @default.
- W3214132407 cites W1982839590 @default.
- W3214132407 cites W1985087138 @default.
- W3214132407 cites W1985436480 @default.
- W3214132407 cites W1985665857 @default.
- W3214132407 cites W1986248905 @default.
- W3214132407 cites W1986873096 @default.
- W3214132407 cites W1988537141 @default.
- W3214132407 cites W1996576721 @default.
- W3214132407 cites W2002922576 @default.
- W3214132407 cites W2002937436 @default.
- W3214132407 cites W2007256995 @default.
- W3214132407 cites W2007761806 @default.
- W3214132407 cites W2012180656 @default.
- W3214132407 cites W2013937462 @default.
- W3214132407 cites W2015189666 @default.
- W3214132407 cites W2015452872 @default.
- W3214132407 cites W2019651479 @default.
- W3214132407 cites W2020349697 @default.
- W3214132407 cites W2021071018 @default.
- W3214132407 cites W2033105957 @default.
- W3214132407 cites W2036161275 @default.
- W3214132407 cites W2037048931 @default.
- W3214132407 cites W2037182429 @default.
- W3214132407 cites W2039340367 @default.
- W3214132407 cites W2040732003 @default.
- W3214132407 cites W2042702713 @default.
- W3214132407 cites W2048871728 @default.
- W3214132407 cites W2049402673 @default.
- W3214132407 cites W2051411849 @default.
- W3214132407 cites W2051963685 @default.
- W3214132407 cites W2052243909 @default.
- W3214132407 cites W2053839218 @default.
- W3214132407 cites W2061372386 @default.
- W3214132407 cites W2061744036 @default.
- W3214132407 cites W2063169093 @default.
- W3214132407 cites W2067449732 @default.
- W3214132407 cites W2069255549 @default.
- W3214132407 cites W2075557750 @default.
- W3214132407 cites W2075726890 @default.
- W3214132407 cites W2078739917 @default.
- W3214132407 cites W2080919844 @default.
- W3214132407 cites W2081325408 @default.
- W3214132407 cites W2082778070 @default.
- W3214132407 cites W2087196823 @default.
- W3214132407 cites W2089669276 @default.
- W3214132407 cites W2092143550 @default.
- W3214132407 cites W2093336696 @default.
- W3214132407 cites W2098651431 @default.
- W3214132407 cites W2103096171 @default.
- W3214132407 cites W2113868111 @default.
- W3214132407 cites W2115486963 @default.
- W3214132407 cites W2117041194 @default.
- W3214132407 cites W2126525177 @default.
- W3214132407 cites W2127536645 @default.
- W3214132407 cites W2128090246 @default.
- W3214132407 cites W2138764615 @default.
- W3214132407 cites W2140488719 @default.
- W3214132407 cites W2145397961 @default.
- W3214132407 cites W2150613986 @default.
- W3214132407 cites W2153821641 @default.
- W3214132407 cites W2155875381 @default.
- W3214132407 cites W2164634060 @default.
- W3214132407 cites W2167345470 @default.
- W3214132407 cites W2168300700 @default.
- W3214132407 cites W2169706900 @default.
- W3214132407 cites W2183361458 @default.
- W3214132407 cites W2230677050 @default.
- W3214132407 cites W2279311208 @default.
- W3214132407 cites W2304223963 @default.
- W3214132407 cites W2320250547 @default.
- W3214132407 cites W2322584397 @default.