FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214140440> ?p ?o ?g. }

• W3214140440 abstract "ABSTRACT Layer 6 corticothalamic (L6 CT) neurons are in a strategic position to control sensory input to the neocortex, yet we understand very little about their functions. Apart from studying their anatomical, physiological and synaptic properties, most recent efforts have focused on the activity-dependent influences CT cells can exert on thalamic and cortical neurons through causal optogenetic manipulations. However, few studies have attempted to study them during behavior. To address this gap, we performed juxtacellular recordings from optogenetically identified CT neurons in whisker-related primary somatosensory cortex (wS1) of awake, head-fixed mice (either sex) free to rest quietly or self-initiate bouts of whisking and locomotion. We found a rich diversity of response profiles exhibited by CT cells. Their spiking patterns were either modulated by whisking-related behavior (∼28%) or not (∼72%). Whisking-responsive neurons exhibited either increases, activated-type, or decreases in firing rates, suppressed-type, that aligned with whisking onset better than locomotion. We also encountered responsive neurons with preceding modulations in firing rate before whisking onset. Overall, whisking better explained these changes in rates than overall changes in arousal. Whisking-unresponsive CT cells were generally quiet, with many having low spontaneous firing rates, sparse-type, and others being completely silent. Remarkably, the sparse firing CT population preferentially spiked at the state transition point when pupil diameter constricted and the mouse entered quiet wakefulness. Thus, our results demonstrate that L6 CT cells in wS1 show diverse spiking patterns, perhaps subserving distinct functional roles related to precisely timed responses during complex behaviors and transitions between discrete waking states. SIGNIFICANCE STATEMENT Layer 6 corticothalamic neurons provide a massive input to the sensory thalamus and local connectivity within cortex, but their role in thalamocortical processing remains unclear due to difficulty accessing and isolating their activity. Although several recent optogenetic studies reveal that the net influence of corticothalamic actions, suppression versus enhancement, depends critically on the rate these neurons fire, the factors that influence their spiking are poorly understood, particularly during wakefulness. Using the well-established Ntsr1-Cre line to target this elusive population in the whisker somatosensory cortex of awake mice, we found that corticothalamic neurons show diverse state-related responses and modulations in firing rate. These results suggest separate corticothalamic populations can differentially influence thalamocortical excitability during rapid state transitions in awake, behaving animals." @default.
• W3214140440 created "2021-11-22" @default.
• W3214140440 creator A5034960866 @default.
• W3214140440 creator A5045883616 @default.
• W3214140440 creator A5071041908 @default.
• W3214140440 date "2021-11-10" @default.
• W3214140440 modified "2023-10-07" @default.
• W3214140440 title "State-dependent modulation of activity in distinct layer 6 corticothalamic neurons in barrel cortex of awake mice" @default.
• W3214140440 cites W1518805832 @default.
• W3214140440 cites W1519578210 @default.
• W3214140440 cites W1799723421 @default.
• W3214140440 cites W1927501767 @default.
• W3214140440 cites W1965680943 @default.
• W3214140440 cites W1965893878 @default.
• W3214140440 cites W1967573437 @default.
• W3214140440 cites W1967857491 @default.
• W3214140440 cites W1968019923 @default.
• W3214140440 cites W1968059634 @default.
• W3214140440 cites W1979258934 @default.
• W3214140440 cites W1984390450 @default.
• W3214140440 cites W1987261355 @default.
• W3214140440 cites W1987332330 @default.
• W3214140440 cites W1990859989 @default.
• W3214140440 cites W1991180842 @default.
• W3214140440 cites W1997523284 @default.
• W3214140440 cites W1998116616 @default.
• W3214140440 cites W1999695968 @default.
• W3214140440 cites W2005056698 @default.
• W3214140440 cites W2018760402 @default.
• W3214140440 cites W2024280848 @default.
• W3214140440 cites W2029513180 @default.
• W3214140440 cites W2036035699 @default.
• W3214140440 cites W2045933100 @default.
• W3214140440 cites W2046384002 @default.
• W3214140440 cites W2046729188 @default.
• W3214140440 cites W2047125044 @default.
• W3214140440 cites W2051361380 @default.
• W3214140440 cites W2055145256 @default.
• W3214140440 cites W2059585285 @default.
• W3214140440 cites W2062297510 @default.
• W3214140440 cites W2065355492 @default.
• W3214140440 cites W2071500241 @default.
• W3214140440 cites W2079041565 @default.
• W3214140440 cites W2080275784 @default.
• W3214140440 cites W2081548183 @default.
• W3214140440 cites W2082973745 @default.
• W3214140440 cites W2084038314 @default.
• W3214140440 cites W2085740291 @default.
• W3214140440 cites W2086338669 @default.
• W3214140440 cites W2087235763 @default.
• W3214140440 cites W2089653659 @default.
• W3214140440 cites W2091111430 @default.
• W3214140440 cites W2093640201 @default.
• W3214140440 cites W2101586252 @default.
• W3214140440 cites W2103113084 @default.
• W3214140440 cites W2104135721 @default.
• W3214140440 cites W2106755999 @default.
• W3214140440 cites W2108897545 @default.
• W3214140440 cites W2113381337 @default.
• W3214140440 cites W2116679324 @default.
• W3214140440 cites W2119227505 @default.
• W3214140440 cites W2121238618 @default.
• W3214140440 cites W2132605695 @default.
• W3214140440 cites W2141250722 @default.
• W3214140440 cites W2142441766 @default.
• W3214140440 cites W2143988681 @default.
• W3214140440 cites W2156432309 @default.
• W3214140440 cites W2163492988 @default.
• W3214140440 cites W2165970664 @default.
• W3214140440 cites W2167279371 @default.
• W3214140440 cites W2176759914 @default.
• W3214140440 cites W2233517735 @default.
• W3214140440 cites W2246750919 @default.
• W3214140440 cites W2284889964 @default.
• W3214140440 cites W2408961640 @default.
• W3214140440 cites W2411237684 @default.
• W3214140440 cites W2429753743 @default.
• W3214140440 cites W2467519109 @default.
• W3214140440 cites W2563523075 @default.
• W3214140440 cites W2565971026 @default.
• W3214140440 cites W2593042581 @default.
• W3214140440 cites W2617502076 @default.
• W3214140440 cites W2625138568 @default.
• W3214140440 cites W2735725811 @default.
• W3214140440 cites W2771661168 @default.
• W3214140440 cites W2789919621 @default.
• W3214140440 cites W2801704011 @default.
• W3214140440 cites W2952738901 @default.
• W3214140440 cites W2965212105 @default.
• W3214140440 cites W2969967332 @default.
• W3214140440 cites W2974656325 @default.
• W3214140440 cites W2985062680 @default.
• W3214140440 cites W3029211407 @default.
• W3214140440 cites W3035916825 @default.
• W3214140440 cites W3040667808 @default.
• W3214140440 cites W3045316332 @default.
• W3214140440 cites W3076806110 @default.
• W3214140440 cites W3095081349 @default.
• W3214140440 cites W3109155306 @default.
• W3214140440 cites W3199086177 @default.

• next