Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214190745> ?p ?o ?g. }
- W3214190745 abstract "ABSTRACT The molecular regulation of human hematopoietic stem cell (HSC) maintenance is therapeutically important, but limitations in experimental systems and interspecies variation have constrained our knowledge of this process. Here, we have studied a rare genetic disorder due to MECOM haploinsufficiency, characterized by an early-onset absence of HSCs in vivo . By generating a faithful model of this disorder in primary human HSCs and coupling functional studies with integrative single-cell genomic analyses, we uncover a key transcriptional network involving hundreds of genes that is required for HSC maintenance. Through our analyses, we nominate cooperating transcriptional regulators and identify how MECOM prevents the CTCF-dependent genome reorganization that occurs as HSCs differentiate. Strikingly, we show that this transcriptional network is co-opted in high-risk leukemias, thereby enabling these cancers to acquire stem cell properties. Collectively, we illuminate a regulatory network necessary for HSC self-renewal through the study of a rare experiment of nature." @default.
- W3214190745 created "2021-11-22" @default.
- W3214190745 creator A5000074913 @default.
- W3214190745 creator A5004067604 @default.
- W3214190745 creator A5010141041 @default.
- W3214190745 creator A5020023487 @default.
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- W3214190745 creator A5038890672 @default.
- W3214190745 creator A5047835252 @default.
- W3214190745 creator A5057553985 @default.
- W3214190745 creator A5059967860 @default.
- W3214190745 creator A5077513980 @default.
- W3214190745 creator A5081944688 @default.
- W3214190745 date "2021-12-09" @default.
- W3214190745 modified "2023-10-12" @default.
- W3214190745 title "A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia" @default.
- W3214190745 cites W1255676896 @default.
- W3214190745 cites W1966530560 @default.
- W3214190745 cites W1967114867 @default.
- W3214190745 cites W1973062929 @default.
- W3214190745 cites W1976712740 @default.
- W3214190745 cites W1977129385 @default.
- W3214190745 cites W1978537489 @default.
- W3214190745 cites W1978902427 @default.
- W3214190745 cites W1982202983 @default.
- W3214190745 cites W1987134040 @default.
- W3214190745 cites W2006379731 @default.
- W3214190745 cites W2022484296 @default.
- W3214190745 cites W2022945065 @default.
- W3214190745 cites W2036492344 @default.
- W3214190745 cites W2038654578 @default.
- W3214190745 cites W2039081870 @default.
- W3214190745 cites W2041418254 @default.
- W3214190745 cites W2044830889 @default.
- W3214190745 cites W2071831776 @default.
- W3214190745 cites W2073680733 @default.
- W3214190745 cites W2081794370 @default.
- W3214190745 cites W2090222361 @default.
- W3214190745 cites W2097175728 @default.
- W3214190745 cites W2103777723 @default.
- W3214190745 cites W2105232554 @default.
- W3214190745 cites W2112362958 @default.
- W3214190745 cites W2116147219 @default.
- W3214190745 cites W2119324304 @default.
- W3214190745 cites W2122125255 @default.
- W3214190745 cites W2122914905 @default.
- W3214190745 cites W2130174662 @default.
- W3214190745 cites W2133295711 @default.
- W3214190745 cites W2140952049 @default.
- W3214190745 cites W2141191556 @default.
- W3214190745 cites W2142410561 @default.
- W3214190745 cites W2149441684 @default.
- W3214190745 cites W2155915458 @default.
- W3214190745 cites W2157952888 @default.
- W3214190745 cites W2171808845 @default.
- W3214190745 cites W2176479760 @default.
- W3214190745 cites W2190545194 @default.
- W3214190745 cites W2341539131 @default.
- W3214190745 cites W2514448720 @default.
- W3214190745 cites W2553838260 @default.
- W3214190745 cites W2558827688 @default.
- W3214190745 cites W2560012305 @default.
- W3214190745 cites W2602848567 @default.
- W3214190745 cites W2617381921 @default.
- W3214190745 cites W2735132087 @default.
- W3214190745 cites W2741508285 @default.
- W3214190745 cites W2743011685 @default.
- W3214190745 cites W2767125719 @default.
- W3214190745 cites W2767749844 @default.
- W3214190745 cites W2768995679 @default.
- W3214190745 cites W2773514102 @default.
- W3214190745 cites W2784423079 @default.
- W3214190745 cites W2789253547 @default.
- W3214190745 cites W2793594275 @default.
- W3214190745 cites W2793743174 @default.
- W3214190745 cites W2794192695 @default.
- W3214190745 cites W2795328021 @default.
- W3214190745 cites W2800392236 @default.
- W3214190745 cites W2886125669 @default.
- W3214190745 cites W2887694579 @default.
- W3214190745 cites W2896480326 @default.
- W3214190745 cites W2897184255 @default.
- W3214190745 cites W2900205062 @default.
- W3214190745 cites W2915459742 @default.
- W3214190745 cites W2922036249 @default.
- W3214190745 cites W2939607165 @default.
- W3214190745 cites W2939923831 @default.
- W3214190745 cites W2942880491 @default.
- W3214190745 cites W2944727022 @default.
- W3214190745 cites W2947742368 @default.
- W3214190745 cites W2952336494 @default.
- W3214190745 cites W2952947531 @default.
- W3214190745 cites W2953047957 @default.
- W3214190745 cites W2964331688 @default.
- W3214190745 cites W2969171012 @default.
- W3214190745 cites W2972483091 @default.
- W3214190745 cites W2984472267 @default.
- W3214190745 cites W2991023348 @default.
- W3214190745 cites W2994805025 @default.