FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214233234> ?p ?o ?g. }

• W3214233234 endingPage "2365" @default.
• W3214233234 startingPage "2365" @default.
• W3214233234 abstract "Acinetobacter baumannii is a Gram-negative coccobacillus responsible for severe hospital-acquired infections, particularly in intensive care units (ICUs). The current study was designed to characterize the virulence traits of biofilm-forming carbapenem-resistant A. baumannii causing pneumonia in ICU patients using a Galleria mellonella model. Two hundred and thirty patients with hospital-acquired or ventilator-associated pneumonia were included in our study. Among the total isolates, A. baumannii was the most frequently isolated etiological agent in ICU patients with pneumonia (54/165, 32.7%). All A. baumannii isolates were subjected to antimicrobial susceptibility testing by the Kirby-Bauer disk diffusion method, while the minimum inhibitory concentrations of imipenem and colistin were estimated using the broth microdilution technique. The biofilm formation activity of the isolates was tested using the microtiter plate technique. Biofilm quantification showed that 61.1% (33/54) of the isolates were strong biofilm producers, while 27.7% (15/54) and 11.1% (6/54) showed moderate or weak biofilm production. By studying the prevalence of carbapenemases-encoding genes among isolates, blaOXA-23-like was positive in 88.9% of the isolates (48/54). The BlaNDM gene was found in 27.7% of the isolates (15/54 isolates). BlaOXA-23-like and blaNDM genes coexisted in 25.9% (14/54 isolates). Bap and blaPER-1 genes, the biofilm-associated genes, coexisted in 5.6% (3/54) of the isolates. For in vivo assessment of A. baumannii pathogenicity, a Galleria mellonella survival assay was used. G. mellonella survival was statistically different between moderate and poor biofilm producers (p < 0.0001). The killing effect of the strong biofilm-producing group was significantly higher than that of the moderate and poor biofilm producers (p < 0.0001 for each comparison). These findings highlight the role of biofilm formation as a powerful virulence factor for carbapenem-resistant A. baumannii that causes pneumonia in the ICU." @default.
• W3214233234 created "2021-11-22" @default.
• W3214233234 creator A5002570163 @default.
• W3214233234 creator A5008753211 @default.
• W3214233234 creator A5018086130 @default.
• W3214233234 creator A5021466237 @default.
• W3214233234 creator A5036161382 @default.
• W3214233234 creator A5045897383 @default.
• W3214233234 creator A5058157329 @default.
• W3214233234 creator A5064102297 @default.
• W3214233234 creator A5066619473 @default.
• W3214233234 creator A5070514889 @default.
• W3214233234 creator A5082235776 @default.
• W3214233234 creator A5083584724 @default.
• W3214233234 creator A5084045344 @default.
• W3214233234 date "2021-11-16" @default.
• W3214233234 modified "2023-10-14" @default.
• W3214233234 title "Virulence Characteristics of Biofilm-Forming Acinetobacter baumannii in Clinical Isolates Using a Galleria mellonella Model" @default.
• W3214233234 cites W1598455636 @default.
• W3214233234 cites W1822354764 @default.
• W3214233234 cites W1929994180 @default.
• W3214233234 cites W1943216040 @default.
• W3214233234 cites W1950672730 @default.
• W3214233234 cites W1964799586 @default.
• W3214233234 cites W1984750475 @default.
• W3214233234 cites W1984809228 @default.
• W3214233234 cites W1985405099 @default.
• W3214233234 cites W1997495012 @default.
• W3214233234 cites W1998160403 @default.
• W3214233234 cites W2002919654 @default.
• W3214233234 cites W2003783897 @default.
• W3214233234 cites W2006850571 @default.
• W3214233234 cites W2006881751 @default.
• W3214233234 cites W2014192657 @default.
• W3214233234 cites W2014408727 @default.
• W3214233234 cites W2020883978 @default.
• W3214233234 cites W2024263059 @default.
• W3214233234 cites W2035522114 @default.
• W3214233234 cites W2037609113 @default.
• W3214233234 cites W2043627773 @default.
• W3214233234 cites W2048310785 @default.
• W3214233234 cites W2055979131 @default.
• W3214233234 cites W2062691302 @default.
• W3214233234 cites W2105161608 @default.
• W3214233234 cites W2107372863 @default.
• W3214233234 cites W2108773674 @default.
• W3214233234 cites W2114568887 @default.
• W3214233234 cites W2115118328 @default.
• W3214233234 cites W2119683190 @default.
• W3214233234 cites W2121645433 @default.
• W3214233234 cites W2124792221 @default.
• W3214233234 cites W2125474282 @default.
• W3214233234 cites W2126480284 @default.
• W3214233234 cites W2127371980 @default.
• W3214233234 cites W2129889303 @default.
• W3214233234 cites W2142828341 @default.
• W3214233234 cites W2146339643 @default.
• W3214233234 cites W2146583750 @default.
• W3214233234 cites W2146964680 @default.
• W3214233234 cites W2148206504 @default.
• W3214233234 cites W2151299416 @default.
• W3214233234 cites W2152673093 @default.
• W3214233234 cites W2155538350 @default.
• W3214233234 cites W2160185557 @default.
• W3214233234 cites W2164139210 @default.
• W3214233234 cites W2168301506 @default.
• W3214233234 cites W2214070200 @default.
• W3214233234 cites W2262769374 @default.
• W3214233234 cites W2277441048 @default.
• W3214233234 cites W2473914511 @default.
• W3214233234 cites W2512577309 @default.
• W3214233234 cites W2529512041 @default.
• W3214233234 cites W2537376417 @default.
• W3214233234 cites W2563162320 @default.
• W3214233234 cites W2578361705 @default.
• W3214233234 cites W2581955658 @default.
• W3214233234 cites W2587556028 @default.
• W3214233234 cites W2606075031 @default.
• W3214233234 cites W2607580877 @default.
• W3214233234 cites W2607620137 @default.
• W3214233234 cites W2612557828 @default.
• W3214233234 cites W2735740016 @default.
• W3214233234 cites W2738855720 @default.
• W3214233234 cites W2767591020 @default.
• W3214233234 cites W2781928079 @default.
• W3214233234 cites W2885657459 @default.
• W3214233234 cites W2888546377 @default.
• W3214233234 cites W2901954715 @default.
• W3214233234 cites W2904193324 @default.
• W3214233234 cites W2942546077 @default.
• W3214233234 cites W2945197482 @default.
• W3214233234 cites W2946458716 @default.
• W3214233234 cites W2962378597 @default.
• W3214233234 cites W2994575890 @default.
• W3214233234 cites W3005745631 @default.
• W3214233234 cites W3086480501 @default.
• W3214233234 cites W3108990568 @default.
• W3214233234 cites W3122807611 @default.

• next