FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214238895> ?p ?o ?g. }

• W3214238895 endingPage "79" @default.
• W3214238895 startingPage "73" @default.
• W3214238895 abstract "Allergic asthma is a heterogeneous inflammatory disorder triggered by inhaled allergens, leading to airflow obstruction, bronchial inflammation, and airway hyperresponsiveness (AHR). T helper (Th) 2 cell-mediated immune response and airway inflammation are the key features of allergic asthma. Bruceine D (BD) is a bioactive compound extracted from the seeds of Brucea javanica. The present study aimed to investigate the effects of increased doses of BD on AHR, secretion of Th1-/Th2-associated cytokines, and inflammatory cell infiltration in ovalbumin (OVA)-induced allergic asthma mice. The results showed that BD reduced OVA-induced inflammatory cell infiltration and bronchial hyperresponsiveness into the peribronchial tissues and perivascular areas. Mice treated with BD also showed significantly decreased expressions of Th2-associated cytokines (i.e., interleukin (IL)-4, IL-5, and IL-13) and elevated production of Th1-associated cytokines (i.e., interferon gamma and IL-2) following OVA stimulation. BD treatment dose-dependently inhibited OVA-induced accumulation of inflammatory cells in asthmatic mice. Further analysis revealed that OVA exposure upregulated pulmonary expressions of NOTCH signaling receptors, a group of transmembrane proteins that communicate signals upon binding to transmembrane ligands expressed on adjacent cells, while BD treatment significantly abolished OVA-induced activation of the NOTCH pathway. In conclusion, BD protected mice against OVA-induced allergic asthma by reducing AHR and restoring the Th1/Th2 balance through the NOTCH signaling pathway. Our findings highlighted the potential of BD as a therapeutic agent for allergic asthma." @default.
• W3214238895 created "2021-11-22" @default.
• W3214238895 creator A5006191181 @default.
• W3214238895 creator A5006898122 @default.
• W3214238895 creator A5035843064 @default.
• W3214238895 creator A5041880317 @default.
• W3214238895 creator A5042511799 @default.
• W3214238895 date "2021-11-04" @default.
• W3214238895 modified "2023-09-23" @default.
• W3214238895 title "Bruceine D ameliorates the balance of Th1/Th2 in a mouse model of ovalbumin-induced allergic asthma via inhibiting the NOTCH pathway" @default.
• W3214238895 cites W150589858 @default.
• W3214238895 cites W1973450930 @default.
• W3214238895 cites W2039441071 @default.
• W3214238895 cites W2043964131 @default.
• W3214238895 cites W2080546770 @default.
• W3214238895 cites W2086782209 @default.
• W3214238895 cites W2114967319 @default.
• W3214238895 cites W2116668018 @default.
• W3214238895 cites W2121459017 @default.
• W3214238895 cites W2557507264 @default.
• W3214238895 cites W2625598332 @default.
• W3214238895 cites W2630417129 @default.
• W3214238895 cites W2743335049 @default.
• W3214238895 cites W2809988035 @default.
• W3214238895 cites W2887425241 @default.
• W3214238895 cites W2914362419 @default.
• W3214238895 cites W2966163873 @default.
• W3214238895 cites W2988920895 @default.
• W3214238895 cites W2989387466 @default.
• W3214238895 cites W2998849120 @default.
• W3214238895 cites W3008728297 @default.
• W3214238895 cites W3015071549 @default.
• W3214238895 cites W3017303929 @default.
• W3214238895 cites W3110011232 @default.
• W3214238895 cites W3128838537 @default.
• W3214238895 cites W3170224159 @default.
• W3214238895 doi "https://doi.org/10.15586/aei.v49i6.499" @default.
• W3214238895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34761661" @default.
• W3214238895 hasPublicationYear "2021" @default.
• W3214238895 type Work @default.
• W3214238895 sameAs 3214238895 @default.
• W3214238895 citedByCount "4" @default.
• W3214238895 countsByYear W32142388952022 @default.
• W3214238895 countsByYear W32142388952023 @default.
• W3214238895 crossrefType "journal-article" @default.
• W3214238895 hasAuthorship W3214238895A5006191181 @default.
• W3214238895 hasAuthorship W3214238895A5006898122 @default.
• W3214238895 hasAuthorship W3214238895A5035843064 @default.
• W3214238895 hasAuthorship W3214238895A5041880317 @default.
• W3214238895 hasAuthorship W3214238895A5042511799 @default.
• W3214238895 hasBestOaLocation W32142388951 @default.
• W3214238895 hasConcept C126322002 @default.
• W3214238895 hasConcept C161879069 @default.
• W3214238895 hasConcept C164027704 @default.
• W3214238895 hasConcept C170493617 @default.
• W3214238895 hasConcept C191732599 @default.
• W3214238895 hasConcept C203014093 @default.
• W3214238895 hasConcept C2776042228 @default.
• W3214238895 hasConcept C2776090121 @default.
• W3214238895 hasConcept C2776178081 @default.
• W3214238895 hasConcept C2776238763 @default.
• W3214238895 hasConcept C2776914184 @default.
• W3214238895 hasConcept C2776946954 @default.
• W3214238895 hasConcept C2777714996 @default.
• W3214238895 hasConcept C2779675166 @default.
• W3214238895 hasConcept C32046619 @default.
• W3214238895 hasConcept C71924100 @default.
• W3214238895 hasConcept C8891405 @default.
• W3214238895 hasConceptScore W3214238895C126322002 @default.
• W3214238895 hasConceptScore W3214238895C161879069 @default.
• W3214238895 hasConceptScore W3214238895C164027704 @default.
• W3214238895 hasConceptScore W3214238895C170493617 @default.
• W3214238895 hasConceptScore W3214238895C191732599 @default.
• W3214238895 hasConceptScore W3214238895C203014093 @default.
• W3214238895 hasConceptScore W3214238895C2776042228 @default.
• W3214238895 hasConceptScore W3214238895C2776090121 @default.
• W3214238895 hasConceptScore W3214238895C2776178081 @default.
• W3214238895 hasConceptScore W3214238895C2776238763 @default.
• W3214238895 hasConceptScore W3214238895C2776914184 @default.
• W3214238895 hasConceptScore W3214238895C2776946954 @default.
• W3214238895 hasConceptScore W3214238895C2777714996 @default.
• W3214238895 hasConceptScore W3214238895C2779675166 @default.
• W3214238895 hasConceptScore W3214238895C32046619 @default.
• W3214238895 hasConceptScore W3214238895C71924100 @default.
• W3214238895 hasConceptScore W3214238895C8891405 @default.
• W3214238895 hasIssue "6" @default.
• W3214238895 hasLocation W32142388951 @default.
• W3214238895 hasLocation W32142388952 @default.
• W3214238895 hasOpenAccess W3214238895 @default.
• W3214238895 hasPrimaryLocation W32142388951 @default.
• W3214238895 hasRelatedWork W1223738143 @default.
• W3214238895 hasRelatedWork W1929917332 @default.
• W3214238895 hasRelatedWork W1988300859 @default.
• W3214238895 hasRelatedWork W2048598556 @default.
• W3214238895 hasRelatedWork W2114335715 @default.
• W3214238895 hasRelatedWork W2133114322 @default.
• W3214238895 hasRelatedWork W2142904066 @default.
• W3214238895 hasRelatedWork W2194413965 @default.

• next