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- W3214244575 abstract "Abstract General cognitive ability (GCA) is an individual difference dimension linked to important academic, occupational, and health-related outcomes and its development is strongly linked to differences in socioeconomic status (SES). Complex abilities of the human brain are realized through interconnections among distributed brain regions, but brain-wide connectivity patterns associated with GCA in youth, and the influence of SES on these connectivity patterns, are poorly understood. The present study examined functional connectomes from 5937 9- and 10-year-olds in the Adolescent Brain Cognitive Development (ABCD) multi-site study. Using multivariate predictive modeling methods, we identified whole-brain functional connectivity patterns linked to GCA. In leave-one-site-out cross-validation, we found these connectivity patterns exhibited strong and statistically reliable generalization at 19 out of 19 held-out sites accounting for 18.0% of the variance in GCA scores (cross-validated partial η 2 ). GCA-related connections were remarkably dispersed across brain networks: across 120 sets of connections linking pairs of large-scale networks, significantly elevated GCA-related connectivity was found in 110 of them, and differences in levels of GCA-related connectivity across brain networks were notably modest. Consistent with prior work, socioeconomic status was a strong predictor of GCA in this sample, and we found that distributed GCA-related brain connectivity patterns significantly statistically mediated this relationship (mean proportion mediated: 15.6%, p < 2 × 10 −16 ). These results demonstrate that socioeconomic status and GCA are related to broad and diffuse differences in functional connectivity architecture during early adolescence, potentially suggesting a mechanism through which socioeconomic status influences cognitive development." @default.
- W3214244575 created "2021-11-22" @default.
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- W3214244575 date "2021-11-08" @default.
- W3214244575 modified "2023-10-16" @default.
- W3214244575 title "Brain-wide functional connectivity patterns support general cognitive ability and mediate effects of socioeconomic status in youth" @default.
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- W3214244575 doi "https://doi.org/10.1038/s41398-021-01704-0" @default.
- W3214244575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8575890" @default.
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- W3214244575 hasPublicationYear "2021" @default.
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