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• W3214280933 abstract "Fibroblast activation protein (FAP), overexpressed on cancer-associated fibroblasts (CAFs), is a novel target for molecular imaging of various tumors. Recently, the development of several small-molecule FAP inhibitors for radiolabeling with 68Ga has resulted in the emergence of studies evaluating its clinical role in cancer imaging. Preliminary findings have demonstrated that, in contrast to radiotracers taking advantage of cancer-specific targets such as PSMA and DOTATATE, FAPs as a target are the most promising that can compete with 18FDG in terms of widespread indications. They also have the potential to overcome the shortcomings of 18FDG, particularly false-positive uptake due to inflammatory or infectious processes, low sensitivity in certain cancer types, and radiotherapy planning. In addition, the attractive theranostic properties may facilitate the treatment of many refractory cancers. This review summarizes the current FAP variants and related clinical studies, focusing on radiopharmacy, dosimetry, and diagnostic and theranostic applications." @default.
• W3214280933 created "2021-11-22" @default.
• W3214280933 creator A5006325338 @default.
• W3214280933 creator A5021842263 @default.
• W3214280933 creator A5044599092 @default.
• W3214280933 date "2021-11-11" @default.
• W3214280933 modified "2023-10-16" @default.
• W3214280933 title "Fibroblast-Activated Protein Inhibitor PET/CT: Cancer Diagnosis and Management" @default.
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• W3214280933 doi "https://doi.org/10.3389/fonc.2021.758958" @default.
• W3214280933 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8632139" @default.
• W3214280933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34858834" @default.
• W3214280933 hasPublicationYear "2021" @default.
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