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W3214323971 abstract "HereditĂĄrnĂ hemoragickĂĄ teleangiektĂĄzie (HHT) je choroba s abnormĂĄlnĂ tvorbou cĂŠv, coĹž vede ke krvĂĄcivĂ˝m komplikacĂm. ZmenĹĄit jejich intenzitu Äi zcela jim zabrĂĄnit mohou antiangiogennĂ lĂŠky, jako je bevacizumab, aflibercept, thalidomid, lenalidomid a dalĹĄĂ ze skupiny antiangiogennĂch inhibitorĹŻ tyrosinkinĂĄz. Jsou ĂşÄinnĂŠ jak pĹi systĂŠmovĂŠm, tak pĹi lokĂĄlnĂm podĂĄnĂ. Tyto novĂŠ lĂŠky pĹibyly ke klasickĂŠ terapii, jako je suplementace Ĺželeza, antifibrinolytika a hormonĂĄlnĂ lĂŠÄba. Tento pĹehled se koncentruje na novĂŠ antiangioproliferativnĂ lĂŠky ĂşÄinnĂŠ u HHT, kterĂŠ mohou bĂ˝t dnes pouĹžity pro lĂŠÄbu, ale naznaÄuje i kterĂŠ lĂŠky se moĹžnĂĄ po ovÄĹenĂ klinickĂ˝mi studiemi dostanou brzy do praxe." @default.
W3214323971 created "2021-11-22" @default.
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W3214323971 date "2021-11-01" @default.
W3214323971 modified "2023-09-26" @default.
W3214323971 title "Hereditary hemorrhagic telangiectasia (Osler‑Weber‑Rendu syndrome) - Part II. Pharmacological therapy and international guidelines for the therapy 2020" @default.
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W3214323971 doi "https://doi.org/10.36290/vnl.2021.110" @default.
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