Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214324881> ?p ?o ?g. }
- W3214324881 endingPage "18" @default.
- W3214324881 startingPage "5" @default.
- W3214324881 abstract "In situ hybridization (ISH) plays an important role in the field of molecular diagnostics, especially in an anatomical pathology laboratory. ISH is a technique that can detect the targeted DNA or RNA sequences in tissue sections from frozen or fixed materials with labeled DNA or RNA probes. Radioactive and non-radioactive probes are the two major probes that can be used to label the targeted nucleic acids.Two decades after the Human Genome Project, ISH has not only simply been applied to identify the chromosomal location of a human gene but has also been extensively applied to gene expressions studies and utilized for clinical diagnosis, especially for the determination of biomarkers for breast and ovarian cancers - human epidermal growth factor receptor 2. Duchenne muscular dystrophy, Cri-du-chat syndrome, Angelman syndrome, PraderWilli syndrome, cystic fibrosis, and trisomy are diseases that can also be detected by ISH. In this review, the basic principles, historical development, advantages and disadvantages, enhancement in reporting molecules and probes, advancement in detection methods, in situ PCR, clinical applications and novel applications of ISH will be discussed.With the advancement in ISH technologies and appropriate training, diagnosis can be improved in Anatomical Pathology." @default.
- W3214324881 created "2021-11-22" @default.
- W3214324881 creator A5008580912 @default.
- W3214324881 creator A5026728288 @default.
- W3214324881 creator A5029276284 @default.
- W3214324881 creator A5045707764 @default.
- W3214324881 creator A5047422707 @default.
- W3214324881 creator A5049313911 @default.
- W3214324881 creator A5050391313 @default.
- W3214324881 creator A5051050481 @default.
- W3214324881 creator A5059319750 @default.
- W3214324881 creator A5069921179 @default.
- W3214324881 creator A5074747989 @default.
- W3214324881 creator A5088282048 @default.
- W3214324881 creator A5088297041 @default.
- W3214324881 date "2021-11-26" @default.
- W3214324881 modified "2023-09-25" @default.
- W3214324881 title "The current and future applications of <i>in situ</i> hybridization technologies in anatomical pathology" @default.
- W3214324881 cites W142357651 @default.
- W3214324881 cites W1557480061 @default.
- W3214324881 cites W1588533075 @default.
- W3214324881 cites W1606413143 @default.
- W3214324881 cites W1782943140 @default.
- W3214324881 cites W1973062929 @default.
- W3214324881 cites W1978505174 @default.
- W3214324881 cites W1979316802 @default.
- W3214324881 cites W1981003442 @default.
- W3214324881 cites W1981272174 @default.
- W3214324881 cites W1999984004 @default.
- W3214324881 cites W2005361347 @default.
- W3214324881 cites W2006789189 @default.
- W3214324881 cites W2007948086 @default.
- W3214324881 cites W2011590297 @default.
- W3214324881 cites W2012128752 @default.
- W3214324881 cites W2016361058 @default.
- W3214324881 cites W2028661385 @default.
- W3214324881 cites W2029523792 @default.
- W3214324881 cites W2030131842 @default.
- W3214324881 cites W2033730876 @default.
- W3214324881 cites W2037306090 @default.
- W3214324881 cites W2043625046 @default.
- W3214324881 cites W2044758669 @default.
- W3214324881 cites W2046493256 @default.
- W3214324881 cites W2049136149 @default.
- W3214324881 cites W2050345568 @default.
- W3214324881 cites W2051825436 @default.
- W3214324881 cites W2065716895 @default.
- W3214324881 cites W2066526257 @default.
- W3214324881 cites W2066649475 @default.
- W3214324881 cites W2068427957 @default.
- W3214324881 cites W2069469382 @default.
- W3214324881 cites W2077899857 @default.
- W3214324881 cites W2080879716 @default.
- W3214324881 cites W2082632351 @default.
- W3214324881 cites W2083278169 @default.
- W3214324881 cites W2086629747 @default.
- W3214324881 cites W2097053416 @default.
- W3214324881 cites W2109601845 @default.
- W3214324881 cites W2122374036 @default.
- W3214324881 cites W2122463596 @default.
- W3214324881 cites W2126537932 @default.
- W3214324881 cites W2126862456 @default.
- W3214324881 cites W2128313472 @default.
- W3214324881 cites W2129757655 @default.
- W3214324881 cites W2141686439 @default.
- W3214324881 cites W2149552563 @default.
- W3214324881 cites W2158440920 @default.
- W3214324881 cites W2165990385 @default.
- W3214324881 cites W2167449077 @default.
- W3214324881 cites W2168917479 @default.
- W3214324881 cites W2301488980 @default.
- W3214324881 cites W2312362840 @default.
- W3214324881 cites W2319902732 @default.
- W3214324881 cites W2331738641 @default.
- W3214324881 cites W2398858783 @default.
- W3214324881 cites W2402071659 @default.
- W3214324881 cites W2471276740 @default.
- W3214324881 cites W2471536144 @default.
- W3214324881 cites W2514644045 @default.
- W3214324881 cites W2520858613 @default.
- W3214324881 cites W2581920909 @default.
- W3214324881 cites W2586503058 @default.
- W3214324881 cites W2610240247 @default.
- W3214324881 cites W2614154655 @default.
- W3214324881 cites W2742349739 @default.
- W3214324881 cites W2783441930 @default.
- W3214324881 cites W2787801274 @default.
- W3214324881 cites W2792537872 @default.
- W3214324881 cites W2801309958 @default.
- W3214324881 cites W2806209829 @default.
- W3214324881 cites W2812344549 @default.
- W3214324881 cites W2889080358 @default.
- W3214324881 cites W2904230974 @default.
- W3214324881 cites W2919091706 @default.
- W3214324881 cites W2923300855 @default.
- W3214324881 cites W2924476045 @default.
- W3214324881 cites W2943975489 @default.
- W3214324881 cites W2991671578 @default.