Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214332783> ?p ?o ?g. }
- W3214332783 endingPage "13837" @default.
- W3214332783 startingPage "13831" @default.
- W3214332783 abstract "The sesquiterpene α-humulene has been shown to have anti-inflammatory and anticancer activities, which has led to its vast application potential in medicine. However, α-humulene production methods including phytoextraction and chemical synthesis currently were limited to low yield, high costs, and expensive catalysts, which cannot meet the increasing market demand. In this study, Yarrowia lipolytica was developed as a robust cell factory for α-humulene production. The peroxisome in Y. lipolytica was first engineered to boost the synthesis of the sesquiterpene α-humulene. By compartmentalization of the α-humulene biosynthesis pathway, improving ATP and acetyl-CoA supply, and optimizing the gene copy numbers of rate-limiting enzymes, the engineered strain GQ2012 could produce 3.2 g/L α-humulene in a 5 L bioreactor, the highest α-humulene titer reported so far. Our study provides a valuable reference for highly sustainable production of terpenoids by peroxisome engineering in Y. lipolytica." @default.
- W3214332783 created "2021-11-22" @default.
- W3214332783 creator A5010323145 @default.
- W3214332783 creator A5018439483 @default.
- W3214332783 creator A5026954484 @default.
- W3214332783 creator A5030348015 @default.
- W3214332783 creator A5062520294 @default.
- W3214332783 creator A5075064641 @default.
- W3214332783 date "2021-11-09" @default.
- W3214332783 modified "2023-10-14" @default.
- W3214332783 title "Harnessing <i>Yarrowia lipolytica</i> Peroxisomes as a Subcellular Factory for α-Humulene Overproduction" @default.
- W3214332783 cites W1787875571 @default.
- W3214332783 cites W1882032094 @default.
- W3214332783 cites W1954160902 @default.
- W3214332783 cites W1975432121 @default.
- W3214332783 cites W1980807215 @default.
- W3214332783 cites W1998501735 @default.
- W3214332783 cites W2012746361 @default.
- W3214332783 cites W2053828247 @default.
- W3214332783 cites W2062068271 @default.
- W3214332783 cites W2064649360 @default.
- W3214332783 cites W2083725517 @default.
- W3214332783 cites W2092167045 @default.
- W3214332783 cites W2105986482 @default.
- W3214332783 cites W2185639583 @default.
- W3214332783 cites W2205785247 @default.
- W3214332783 cites W2401639742 @default.
- W3214332783 cites W2410761017 @default.
- W3214332783 cites W2485902845 @default.
- W3214332783 cites W2511727539 @default.
- W3214332783 cites W2537985711 @default.
- W3214332783 cites W2587955894 @default.
- W3214332783 cites W2588403571 @default.
- W3214332783 cites W2606736518 @default.
- W3214332783 cites W2624188796 @default.
- W3214332783 cites W2739891962 @default.
- W3214332783 cites W2762949402 @default.
- W3214332783 cites W2771652005 @default.
- W3214332783 cites W2784177064 @default.
- W3214332783 cites W2810587442 @default.
- W3214332783 cites W2883884122 @default.
- W3214332783 cites W2901121611 @default.
- W3214332783 cites W2947406717 @default.
- W3214332783 cites W2951601171 @default.
- W3214332783 cites W2965377603 @default.
- W3214332783 cites W2969728610 @default.
- W3214332783 cites W2988978830 @default.
- W3214332783 cites W3000200402 @default.
- W3214332783 cites W3022456443 @default.
- W3214332783 cites W3025736323 @default.
- W3214332783 cites W3038590987 @default.
- W3214332783 cites W3091919455 @default.
- W3214332783 cites W3104188728 @default.
- W3214332783 cites W3108222170 @default.
- W3214332783 cites W3131810132 @default.
- W3214332783 cites W3156497487 @default.
- W3214332783 cites W3158116527 @default.
- W3214332783 cites W3174649611 @default.
- W3214332783 doi "https://doi.org/10.1021/acs.jafc.1c05897" @default.
- W3214332783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34751575" @default.
- W3214332783 hasPublicationYear "2021" @default.
- W3214332783 type Work @default.
- W3214332783 sameAs 3214332783 @default.
- W3214332783 citedByCount "20" @default.
- W3214332783 countsByYear W32143327832022 @default.
- W3214332783 countsByYear W32143327832023 @default.
- W3214332783 crossrefType "journal-article" @default.
- W3214332783 hasAuthorship W3214332783A5010323145 @default.
- W3214332783 hasAuthorship W3214332783A5018439483 @default.
- W3214332783 hasAuthorship W3214332783A5026954484 @default.
- W3214332783 hasAuthorship W3214332783A5030348015 @default.
- W3214332783 hasAuthorship W3214332783A5062520294 @default.
- W3214332783 hasAuthorship W3214332783A5075064641 @default.
- W3214332783 hasConcept C104317684 @default.
- W3214332783 hasConcept C124420848 @default.
- W3214332783 hasConcept C127078168 @default.
- W3214332783 hasConcept C150903083 @default.
- W3214332783 hasConcept C181199279 @default.
- W3214332783 hasConcept C185592680 @default.
- W3214332783 hasConcept C2777278459 @default.
- W3214332783 hasConcept C2777291603 @default.
- W3214332783 hasConcept C2779222958 @default.
- W3214332783 hasConcept C2779490540 @default.
- W3214332783 hasConcept C31903555 @default.
- W3214332783 hasConcept C55493867 @default.
- W3214332783 hasConcept C6350086 @default.
- W3214332783 hasConcept C86803240 @default.
- W3214332783 hasConceptScore W3214332783C104317684 @default.
- W3214332783 hasConceptScore W3214332783C124420848 @default.
- W3214332783 hasConceptScore W3214332783C127078168 @default.
- W3214332783 hasConceptScore W3214332783C150903083 @default.
- W3214332783 hasConceptScore W3214332783C181199279 @default.
- W3214332783 hasConceptScore W3214332783C185592680 @default.
- W3214332783 hasConceptScore W3214332783C2777278459 @default.
- W3214332783 hasConceptScore W3214332783C2777291603 @default.
- W3214332783 hasConceptScore W3214332783C2779222958 @default.
- W3214332783 hasConceptScore W3214332783C2779490540 @default.
- W3214332783 hasConceptScore W3214332783C31903555 @default.