FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214350614> ?p ?o ?g. }

• W3214350614 endingPage "434" @default.
• W3214350614 startingPage "427" @default.
• W3214350614 abstract "A pathogenic variant in the gene encoding phospholamban (PLN), a protein that regulates calcium homeostasis of cardiomyocytes, causes PLN cardiomyopathy. It is characterized by a high arrhythmic burden and can progress to severe cardiomyopathy. Risk assessment guides implantable cardioverter-defibrillator therapy and benefits from personalization. Whether sex-specific differences in PLN cardiomyopathy exist is unknown.The purpose of this study was to improve the accuracy of PLN cardiomyopathy diagnosis and risk assessment by investigating sex-specific aspects.We analyzed a multicenter cohort of 933 patients (412 male, 521 female) with the PLN p.(Arg14del) pathogenic variant following up on a recently developed PLN risk model. Sex-specific differences in the incidence of risk model components were investigated: low-voltage electrocardiogram (ECG), premature ventricular contractions, negative T waves, and left ventricular ejection fraction.Sustained ventricular arrhythmias (VAs) occurred in 77 males (18.7%) and 61 females (11.7%) (P = .004). Of the 933 cohort members, 287 (31%) had ≥1 low-voltage ECG during follow-up (180 females [63%], 107 males [37%]; P = .006). Female sex, age, age at clinical presentation, and proband status predicted low-voltage ECG during follow-up (area under the curve: 0.78). Sustained VA-free survival was lowest in males with low-voltage ECG (P <.001).Low-voltage ECGs predict sustained VA and are a component of the PLN risk model. Low-voltage ECGs are more common in females, yet prognostic value is greater in males. Future studies should determine the impact of this difference on the risk prediction of PLN cardiomyopathy and possibly other cardiomyopathies." @default.
• W3214350614 created "2021-11-22" @default.
• W3214350614 creator A5002151074 @default.
• W3214350614 creator A5006795571 @default.
• W3214350614 creator A5008850936 @default.
• W3214350614 creator A5010488205 @default.
• W3214350614 creator A5011877746 @default.
• W3214350614 creator A5025606739 @default.
• W3214350614 creator A5026444475 @default.
• W3214350614 creator A5047299708 @default.
• W3214350614 creator A5051807425 @default.
• W3214350614 creator A5056415259 @default.
• W3214350614 creator A5065116979 @default.
• W3214350614 creator A5071245005 @default.
• W3214350614 creator A5087108967 @default.
• W3214350614 date "2022-03-01" @default.
• W3214350614 modified "2023-10-18" @default.
• W3214350614 title "Sex-specific aspects of phospholamban cardiomyopathy: The importance and prognostic value of low-voltage electrocardiograms" @default.
• W3214350614 cites W1973604073 @default.
• W3214350614 cites W2009415943 @default.
• W3214350614 cites W2080625632 @default.
• W3214350614 cites W2101260854 @default.
• W3214350614 cites W2118549020 @default.
• W3214350614 cites W2139331439 @default.
• W3214350614 cites W2146665756 @default.
• W3214350614 cites W2170124209 @default.
• W3214350614 cites W2259258993 @default.
• W3214350614 cites W2265858828 @default.
• W3214350614 cites W2556053991 @default.
• W3214350614 cites W2883338911 @default.
• W3214350614 cites W2904739952 @default.
• W3214350614 cites W2937348604 @default.
• W3214350614 cites W2989620313 @default.
• W3214350614 cites W2989958746 @default.
• W3214350614 cites W3013574129 @default.
• W3214350614 cites W3147247738 @default.
• W3214350614 cites W3160578854 @default.
• W3214350614 cites W3170894067 @default.
• W3214350614 doi "https://doi.org/10.1016/j.hrthm.2021.11.009" @default.
• W3214350614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34767988" @default.
• W3214350614 hasPublicationYear "2022" @default.
• W3214350614 type Work @default.
• W3214350614 sameAs 3214350614 @default.
• W3214350614 citedByCount "4" @default.
• W3214350614 countsByYear W32143506142022 @default.
• W3214350614 countsByYear W32143506142023 @default.
• W3214350614 crossrefType "journal-article" @default.
• W3214350614 hasAuthorship W3214350614A5002151074 @default.
• W3214350614 hasAuthorship W3214350614A5006795571 @default.
• W3214350614 hasAuthorship W3214350614A5008850936 @default.
• W3214350614 hasAuthorship W3214350614A5010488205 @default.
• W3214350614 hasAuthorship W3214350614A5011877746 @default.
• W3214350614 hasAuthorship W3214350614A5025606739 @default.
• W3214350614 hasAuthorship W3214350614A5026444475 @default.
• W3214350614 hasAuthorship W3214350614A5047299708 @default.
• W3214350614 hasAuthorship W3214350614A5051807425 @default.
• W3214350614 hasAuthorship W3214350614A5056415259 @default.
• W3214350614 hasAuthorship W3214350614A5065116979 @default.
• W3214350614 hasAuthorship W3214350614A5071245005 @default.
• W3214350614 hasAuthorship W3214350614A5087108967 @default.
• W3214350614 hasBestOaLocation W32143506141 @default.
• W3214350614 hasConcept C126322002 @default.
• W3214350614 hasConcept C164705383 @default.
• W3214350614 hasConcept C17137333 @default.
• W3214350614 hasConcept C2777093960 @default.
• W3214350614 hasConcept C2778198053 @default.
• W3214350614 hasConcept C2778797674 @default.
• W3214350614 hasConcept C2780185194 @default.
• W3214350614 hasConcept C71924100 @default.
• W3214350614 hasConcept C72563966 @default.
• W3214350614 hasConcept C78085059 @default.
• W3214350614 hasConceptScore W3214350614C126322002 @default.
• W3214350614 hasConceptScore W3214350614C164705383 @default.
• W3214350614 hasConceptScore W3214350614C17137333 @default.
• W3214350614 hasConceptScore W3214350614C2777093960 @default.
• W3214350614 hasConceptScore W3214350614C2778198053 @default.
• W3214350614 hasConceptScore W3214350614C2778797674 @default.
• W3214350614 hasConceptScore W3214350614C2780185194 @default.
• W3214350614 hasConceptScore W3214350614C71924100 @default.
• W3214350614 hasConceptScore W3214350614C72563966 @default.
• W3214350614 hasConceptScore W3214350614C78085059 @default.
• W3214350614 hasFunder F4320320890 @default.
• W3214350614 hasFunder F4320321642 @default.
• W3214350614 hasFunder F4320338335 @default.
• W3214350614 hasIssue "3" @default.
• W3214350614 hasLocation W32143506141 @default.
• W3214350614 hasLocation W32143506142 @default.
• W3214350614 hasLocation W32143506143 @default.
• W3214350614 hasLocation W32143506144 @default.
• W3214350614 hasOpenAccess W3214350614 @default.
• W3214350614 hasPrimaryLocation W32143506141 @default.
• W3214350614 hasRelatedWork W2051712573 @default.
• W3214350614 hasRelatedWork W2077083067 @default.
• W3214350614 hasRelatedWork W2091139515 @default.
• W3214350614 hasRelatedWork W2355594703 @default.
• W3214350614 hasRelatedWork W2361407492 @default.
• W3214350614 hasRelatedWork W2538662566 @default.
• W3214350614 hasRelatedWork W2893223956 @default.

• next