Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214430285> ?p ?o ?g. }
- W3214430285 abstract "Abstract The RNA recognition motif (RRM) binds to nucleic acids as well as proteins. More than one such domain is found in the pre-mRNA processing hnRNP proteins. While the mode of RNA recognition by RRMs is known, the molecular basis of their protein interaction remains obscure. Here we describe the mode of interaction between hnRNP L and LL with the methyltransferase SETD2. We demonstrate that for the interaction to occur, a leucine pair within a highly conserved stretch of SETD2 insert their side chains in hydrophobic pockets formed by hnRNP L RRM2. Notably, the structure also highlights that RRM2 can form a ternary complex with SETD2 and RNA. Remarkably, mutating the leucine pair in SETD2 also results in its reduced interaction with other hnRNPs. Importantly, the similarity that the mode of SETD2-hnRNP L interaction shares with other related protein-protein interactions reveals a conserved design by which splicing regulators interact with one another." @default.
- W3214430285 created "2021-11-22" @default.
- W3214430285 creator A5016735111 @default.
- W3214430285 creator A5017521861 @default.
- W3214430285 creator A5026935413 @default.
- W3214430285 creator A5027561107 @default.
- W3214430285 creator A5034566006 @default.
- W3214430285 creator A5042973046 @default.
- W3214430285 creator A5054418515 @default.
- W3214430285 creator A5059586165 @default.
- W3214430285 creator A5068374049 @default.
- W3214430285 creator A5069631252 @default.
- W3214430285 creator A5085060131 @default.
- W3214430285 creator A5088793206 @default.
- W3214430285 date "2021-11-08" @default.
- W3214430285 modified "2023-10-16" @default.
- W3214430285 title "Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing" @default.
- W3214430285 cites W1063166136 @default.
- W3214430285 cites W1539796472 @default.
- W3214430285 cites W1597678601 @default.
- W3214430285 cites W1847006015 @default.
- W3214430285 cites W1864029557 @default.
- W3214430285 cites W1968395373 @default.
- W3214430285 cites W1972059985 @default.
- W3214430285 cites W1984303280 @default.
- W3214430285 cites W1986156026 @default.
- W3214430285 cites W1990299806 @default.
- W3214430285 cites W1992274603 @default.
- W3214430285 cites W1999491723 @default.
- W3214430285 cites W2004509913 @default.
- W3214430285 cites W2004857585 @default.
- W3214430285 cites W2011920499 @default.
- W3214430285 cites W2015568775 @default.
- W3214430285 cites W2018608365 @default.
- W3214430285 cites W2024036230 @default.
- W3214430285 cites W2028299201 @default.
- W3214430285 cites W2029668455 @default.
- W3214430285 cites W2031628458 @default.
- W3214430285 cites W2032019813 @default.
- W3214430285 cites W2036247643 @default.
- W3214430285 cites W2039201797 @default.
- W3214430285 cites W2051288343 @default.
- W3214430285 cites W2051612352 @default.
- W3214430285 cites W2052418876 @default.
- W3214430285 cites W2058490161 @default.
- W3214430285 cites W2065701448 @default.
- W3214430285 cites W2066231767 @default.
- W3214430285 cites W2072863253 @default.
- W3214430285 cites W2074986801 @default.
- W3214430285 cites W2078138443 @default.
- W3214430285 cites W2087744052 @default.
- W3214430285 cites W2087815448 @default.
- W3214430285 cites W2098391569 @default.
- W3214430285 cites W2109839614 @default.
- W3214430285 cites W2110304444 @default.
- W3214430285 cites W2114104545 @default.
- W3214430285 cites W2114212941 @default.
- W3214430285 cites W2117505670 @default.
- W3214430285 cites W2123508298 @default.
- W3214430285 cites W2124026197 @default.
- W3214430285 cites W2127604631 @default.
- W3214430285 cites W2132187095 @default.
- W3214430285 cites W2132811240 @default.
- W3214430285 cites W2139732110 @default.
- W3214430285 cites W2146080841 @default.
- W3214430285 cites W2151462466 @default.
- W3214430285 cites W2151464048 @default.
- W3214430285 cites W2155804510 @default.
- W3214430285 cites W2158978257 @default.
- W3214430285 cites W2163341755 @default.
- W3214430285 cites W2164134985 @default.
- W3214430285 cites W2168728470 @default.
- W3214430285 cites W2168974130 @default.
- W3214430285 cites W2169456326 @default.
- W3214430285 cites W2170518899 @default.
- W3214430285 cites W2180229411 @default.
- W3214430285 cites W2182963873 @default.
- W3214430285 cites W2361260139 @default.
- W3214430285 cites W2376573086 @default.
- W3214430285 cites W2408427435 @default.
- W3214430285 cites W2471157725 @default.
- W3214430285 cites W2477792987 @default.
- W3214430285 cites W2555691968 @default.
- W3214430285 cites W2584595943 @default.
- W3214430285 cites W2740447116 @default.
- W3214430285 cites W2746222363 @default.
- W3214430285 cites W2789750843 @default.
- W3214430285 cites W2806884808 @default.
- W3214430285 cites W2918063357 @default.
- W3214430285 cites W2938574745 @default.
- W3214430285 cites W2948201174 @default.
- W3214430285 cites W2973457155 @default.
- W3214430285 cites W3021909538 @default.
- W3214430285 cites W3091793847 @default.
- W3214430285 cites W3134003445 @default.
- W3214430285 cites W3193089943 @default.
- W3214430285 doi "https://doi.org/10.1038/s41467-021-26799-3" @default.
- W3214430285 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8575775" @default.
- W3214430285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34750379" @default.
- W3214430285 hasPublicationYear "2021" @default.