Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214455452> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3214455452 endingPage "1100" @default.
- W3214455452 startingPage "1091" @default.
- W3214455452 abstract "For many years, lipid nanoparticles (LNPs) have been used as delivery vehicles for various payloads (especially various oligonucleotides and mRNA), finding numerous applications in drug and vaccine development. LNP stability and bilayer fluidity are determined by the identities and the amounts of the various lipids employed in the formulation and LNP efficacy is determined in large part by the lipid composition which usually contains a cationic lipid, a PEG-lipid conjugate, cholesterol, and a zwitterionic helper phospholipid. Analytical methods developed for LNP characterization must be able to determine not only the identity and content of each individual lipid component (i.e., the parent lipids), but also the associated impurities and degradants. In this work, we describe an efficient and sensitive reversed-phase chromatographic method with charged aerosol detection (CAD) suitable for this purpose. Sample preparation diluent and mobile phase pH conditions are critical and have been optimized for the lipids of interest. This method was validated for its linearity, accuracy, precision, and specificity for lipid analysis to support process and formulation development for new drugs and vaccines." @default.
- W3214455452 created "2021-11-22" @default.
- W3214455452 creator A5001494090 @default.
- W3214455452 creator A5009802003 @default.
- W3214455452 creator A5032822422 @default.
- W3214455452 creator A5040374979 @default.
- W3214455452 creator A5064046237 @default.
- W3214455452 creator A5070919006 @default.
- W3214455452 creator A5080330129 @default.
- W3214455452 date "2021-12-21" @default.
- W3214455452 modified "2023-10-16" @default.
- W3214455452 title "Determination of lipid content and stability in lipid nanoparticles using ultra high‐performance liquid chromatography in combination with a Corona Charged Aerosol Detector" @default.
- W3214455452 cites W1969727300 @default.
- W3214455452 cites W1972882797 @default.
- W3214455452 cites W1977272867 @default.
- W3214455452 cites W1979311824 @default.
- W3214455452 cites W1980257330 @default.
- W3214455452 cites W1983316742 @default.
- W3214455452 cites W1987433127 @default.
- W3214455452 cites W1992470420 @default.
- W3214455452 cites W2020008249 @default.
- W3214455452 cites W2032252971 @default.
- W3214455452 cites W2045381262 @default.
- W3214455452 cites W2050305665 @default.
- W3214455452 cites W2059355578 @default.
- W3214455452 cites W2060522306 @default.
- W3214455452 cites W2060889576 @default.
- W3214455452 cites W2082012564 @default.
- W3214455452 cites W2171245233 @default.
- W3214455452 cites W2189965380 @default.
- W3214455452 cites W2600400434 @default.
- W3214455452 cites W2950423944 @default.
- W3214455452 cites W3044891199 @default.
- W3214455452 cites W3087924281 @default.
- W3214455452 cites W3096720517 @default.
- W3214455452 doi "https://doi.org/10.1002/elps.202100244" @default.
- W3214455452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34784061" @default.
- W3214455452 hasPublicationYear "2021" @default.
- W3214455452 type Work @default.
- W3214455452 sameAs 3214455452 @default.
- W3214455452 citedByCount "9" @default.
- W3214455452 countsByYear W32144554522022 @default.
- W3214455452 countsByYear W32144554522023 @default.
- W3214455452 crossrefType "journal-article" @default.
- W3214455452 hasAuthorship W3214455452A5001494090 @default.
- W3214455452 hasAuthorship W3214455452A5009802003 @default.
- W3214455452 hasAuthorship W3214455452A5032822422 @default.
- W3214455452 hasAuthorship W3214455452A5040374979 @default.
- W3214455452 hasAuthorship W3214455452A5064046237 @default.
- W3214455452 hasAuthorship W3214455452A5070919006 @default.
- W3214455452 hasAuthorship W3214455452A5080330129 @default.
- W3214455452 hasBestOaLocation W32144554521 @default.
- W3214455452 hasConcept C185592680 @default.
- W3214455452 hasConcept C192157962 @default.
- W3214455452 hasConcept C2778918659 @default.
- W3214455452 hasConcept C39944091 @default.
- W3214455452 hasConcept C41625074 @default.
- W3214455452 hasConcept C43617362 @default.
- W3214455452 hasConcept C55493867 @default.
- W3214455452 hasConceptScore W3214455452C185592680 @default.
- W3214455452 hasConceptScore W3214455452C192157962 @default.
- W3214455452 hasConceptScore W3214455452C2778918659 @default.
- W3214455452 hasConceptScore W3214455452C39944091 @default.
- W3214455452 hasConceptScore W3214455452C41625074 @default.
- W3214455452 hasConceptScore W3214455452C43617362 @default.
- W3214455452 hasConceptScore W3214455452C55493867 @default.
- W3214455452 hasIssue "9-10" @default.
- W3214455452 hasLocation W32144554521 @default.
- W3214455452 hasLocation W32144554522 @default.
- W3214455452 hasLocation W32144554523 @default.
- W3214455452 hasOpenAccess W3214455452 @default.
- W3214455452 hasPrimaryLocation W32144554521 @default.
- W3214455452 hasRelatedWork W1970576699 @default.
- W3214455452 hasRelatedWork W1985078324 @default.
- W3214455452 hasRelatedWork W2000369071 @default.
- W3214455452 hasRelatedWork W2000445617 @default.
- W3214455452 hasRelatedWork W2016084400 @default.
- W3214455452 hasRelatedWork W2032449844 @default.
- W3214455452 hasRelatedWork W2090342020 @default.
- W3214455452 hasRelatedWork W2091798545 @default.
- W3214455452 hasRelatedWork W2461364449 @default.
- W3214455452 hasRelatedWork W2516941361 @default.
- W3214455452 hasVolume "43" @default.
- W3214455452 isParatext "false" @default.
- W3214455452 isRetracted "false" @default.
- W3214455452 magId "3214455452" @default.
- W3214455452 workType "article" @default.