FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214458136> ?p ?o ?g. }

• W3214458136 endingPage "147" @default.
• W3214458136 startingPage "138" @default.
• W3214458136 abstract "Pleomorphic rhabdomyosarcoma (PRMS) is a rare and aggressive adult sarcoma with a median overall survival of less than 2 years. Most PRMS do not respond to conventional chemotherapy and/or radiation, and targeted therapies are nonexistent as few PRMS have undergone the molecular characterization necessary to identify therapeutic options. To date, complex structural and few recurrent regional copy alterations have been reported in the PRMS cases evaluated by cytogenetic and comparative genomic hybridization. Thus, there remains an urgent need for more comprehensive molecular profiling to both understand disease pathogenesis and to identify potentially actionable targets. Ten PRMS resection cases were retrieved from institutional archives and clinicopathologic demographics were recorded. All tumors were subjected to DNA-based targeted next-generation sequencing (NGS) of 340 cancer-related genes while a subset (six cases) underwent gene-expression profiling of 770 genes. Alterations identified by NGS included genes involved in cell cycle regulation (90%), the RAS/MAPK and AKT pathways (80%), telomere maintenance (40%), chromatin remodeling (40%), and DNA repair (20%), as well as the cAMP-signaling pathway (10%). Microsatellite instability was absent in all cases, and tumor mutational burden was predominantly low. Gene expression profiling revealed up-regulation of many of the same pathways, including the RTK/MAPK, AKT/PIK3CA/mTOR, Wnt, Hedgehog and JAK/STAT pathways. Survival analysis demonstrated patients with concurrent biallelic inactivation of CDKN2A and TP53 showed significantly shorter overall survival (median: 2 vs. 50 months). Our integrated molecular characterization identified not only potentially targetable alterations, but also prognostic markers for stratification of PRMS patients." @default.
• W3214458136 created "2021-11-22" @default.
• W3214458136 creator A5039590628 @default.
• W3214458136 creator A5040922566 @default.
• W3214458136 creator A5074390982 @default.
• W3214458136 date "2021-12-02" @default.
• W3214458136 modified "2023-09-24" @default.
• W3214458136 title "Molecular analysis of 10 pleomorphic rhabdomyosarcomas reveals potential prognostic markers and druggable targets" @default.
• W3214458136 cites W1520287492 @default.
• W3214458136 cites W1987100596 @default.
• W3214458136 cites W1997445678 @default.
• W3214458136 cites W1998686034 @default.
• W3214458136 cites W1998970984 @default.
• W3214458136 cites W2003073792 @default.
• W3214458136 cites W2025497420 @default.
• W3214458136 cites W2027853345 @default.
• W3214458136 cites W2044060805 @default.
• W3214458136 cites W2048795040 @default.
• W3214458136 cites W2057188721 @default.
• W3214458136 cites W2060352282 @default.
• W3214458136 cites W2063383646 @default.
• W3214458136 cites W2065891752 @default.
• W3214458136 cites W2066604004 @default.
• W3214458136 cites W2081056387 @default.
• W3214458136 cites W2094044666 @default.
• W3214458136 cites W2114843025 @default.
• W3214458136 cites W2122961149 @default.
• W3214458136 cites W2127736279 @default.
• W3214458136 cites W2129769331 @default.
• W3214458136 cites W2149441684 @default.
• W3214458136 cites W2151793483 @default.
• W3214458136 cites W2156021518 @default.
• W3214458136 cites W2157259439 @default.
• W3214458136 cites W2187845981 @default.
• W3214458136 cites W2188189858 @default.
• W3214458136 cites W2316838404 @default.
• W3214458136 cites W2606495925 @default.
• W3214458136 cites W2788240814 @default.
• W3214458136 cites W2791303335 @default.
• W3214458136 cites W2892230595 @default.
• W3214458136 cites W2897392995 @default.
• W3214458136 cites W2933383115 @default.
• W3214458136 cites W2948356525 @default.
• W3214458136 cites W2948756637 @default.
• W3214458136 cites W2963725488 @default.
• W3214458136 cites W2964550053 @default.
• W3214458136 cites W2981838572 @default.
• W3214458136 cites W3004981089 @default.
• W3214458136 cites W3011727508 @default.
• W3214458136 cites W3034208461 @default.
• W3214458136 cites W3035803530 @default.
• W3214458136 cites W3043206481 @default.
• W3214458136 cites W3045783956 @default.
• W3214458136 cites W3046481115 @default.
• W3214458136 cites W848101669 @default.
• W3214458136 doi "https://doi.org/10.1002/gcc.23013" @default.
• W3214458136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34773670" @default.
• W3214458136 hasPublicationYear "2021" @default.
• W3214458136 type Work @default.
• W3214458136 sameAs 3214458136 @default.
• W3214458136 citedByCount "5" @default.
• W3214458136 countsByYear W32144581362022 @default.
• W3214458136 countsByYear W32144581362023 @default.
• W3214458136 crossrefType "journal-article" @default.
• W3214458136 hasAuthorship W3214458136A5039590628 @default.
• W3214458136 hasAuthorship W3214458136A5040922566 @default.
• W3214458136 hasAuthorship W3214458136A5074390982 @default.
• W3214458136 hasConcept C104317684 @default.
• W3214458136 hasConcept C121608353 @default.
• W3214458136 hasConcept C124942203 @default.
• W3214458136 hasConcept C137620995 @default.
• W3214458136 hasConcept C141231307 @default.
• W3214458136 hasConcept C143998085 @default.
• W3214458136 hasConcept C150194340 @default.
• W3214458136 hasConcept C18431079 @default.
• W3214458136 hasConcept C2777609662 @default.
• W3214458136 hasConcept C2780265364 @default.
• W3214458136 hasConcept C2781230642 @default.
• W3214458136 hasConcept C502942594 @default.
• W3214458136 hasConcept C54355233 @default.
• W3214458136 hasConcept C60644358 @default.
• W3214458136 hasConcept C62478195 @default.
• W3214458136 hasConcept C71924100 @default.
• W3214458136 hasConcept C86554907 @default.
• W3214458136 hasConcept C86803240 @default.
• W3214458136 hasConceptScore W3214458136C104317684 @default.
• W3214458136 hasConceptScore W3214458136C121608353 @default.
• W3214458136 hasConceptScore W3214458136C124942203 @default.
• W3214458136 hasConceptScore W3214458136C137620995 @default.
• W3214458136 hasConceptScore W3214458136C141231307 @default.
• W3214458136 hasConceptScore W3214458136C143998085 @default.
• W3214458136 hasConceptScore W3214458136C150194340 @default.
• W3214458136 hasConceptScore W3214458136C18431079 @default.
• W3214458136 hasConceptScore W3214458136C2777609662 @default.
• W3214458136 hasConceptScore W3214458136C2780265364 @default.
• W3214458136 hasConceptScore W3214458136C2781230642 @default.
• W3214458136 hasConceptScore W3214458136C502942594 @default.
• W3214458136 hasConceptScore W3214458136C54355233 @default.

• next