Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214501501> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W3214501501 abstract "Objective: To investigate the association of adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) polymorphism C3435T with anti-emetic efficacy in patients treated with ondansetron for preventing post-operative nausea and vomiting (PONV).Study Design: A prospective, clinical trial.Place and Duration of Study: Clinical data collection and blood sampling carried out at Combined Military Hospital, Rawalpindi and genetic analysis carried out at Institute of Biomedical and Genetic Engineering, Islamabad from Aug 2012 to Sep 2013.Material and Methods: Ondansetron was administered in a dose of 4 mg intravenously 30 minutes before the end of surgery. Peripheral blood was withdrawn from 491 patients who had planned laparoscopic cholecystectomy under general anesthesia. A total of 249 patients with complaints of nausea and vomiting and 242 patients without nausea and vomiting were analyzed for C3435T polymorphism using polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) method.Results: The results showed the patients with CC and CT genotype of ABCB1 C3435T had significantly higher incidence of nausea and vomiting (p<0.05) while patients with TT genotype had significantly lower incidence of post-operative nausea and vomiting during the first two hours after surgery (p<0.05).Conclusion: It is concluded that polymorphism of ABCB1 may be a good guide for predicting responsiveness of ondansetron and there is a role of genetics in the management of PONV." @default.
- W3214501501 created "2021-11-22" @default.
- W3214501501 creator A5002718565 @default.
- W3214501501 creator A5015622959 @default.
- W3214501501 creator A5017179658 @default.
- W3214501501 creator A5018083399 @default.
- W3214501501 creator A5022404736 @default.
- W3214501501 creator A5054406306 @default.
- W3214501501 date "2016-10-31" @default.
- W3214501501 modified "2023-09-27" @default.
- W3214501501 title "THE IMPACT OF ABCB1 (C3435T) POLYMORPHISM ON THE EFFICACY OF ONDANSETRON FOR POST-OPERATIVE NAUSEA AND VOMITING IN PAKISTANI POPULATION" @default.
- W3214501501 cites W1964081644 @default.
- W3214501501 cites W1998071425 @default.
- W3214501501 cites W2002800880 @default.
- W3214501501 cites W2039288367 @default.
- W3214501501 cites W2054458932 @default.
- W3214501501 cites W2064099934 @default.
- W3214501501 cites W2068865770 @default.
- W3214501501 cites W2154735290 @default.
- W3214501501 cites W2160265221 @default.
- W3214501501 cites W2163636362 @default.
- W3214501501 cites W2330472653 @default.
- W3214501501 hasPublicationYear "2016" @default.
- W3214501501 type Work @default.
- W3214501501 sameAs 3214501501 @default.
- W3214501501 citedByCount "0" @default.
- W3214501501 crossrefType "journal-article" @default.
- W3214501501 hasAuthorship W3214501501A5002718565 @default.
- W3214501501 hasAuthorship W3214501501A5015622959 @default.
- W3214501501 hasAuthorship W3214501501A5017179658 @default.
- W3214501501 hasAuthorship W3214501501A5018083399 @default.
- W3214501501 hasAuthorship W3214501501A5022404736 @default.
- W3214501501 hasAuthorship W3214501501A5054406306 @default.
- W3214501501 hasConcept C120665830 @default.
- W3214501501 hasConcept C121332964 @default.
- W3214501501 hasConcept C126322002 @default.
- W3214501501 hasConcept C2777170512 @default.
- W3214501501 hasConcept C2777297131 @default.
- W3214501501 hasConcept C2780580376 @default.
- W3214501501 hasConcept C2780852908 @default.
- W3214501501 hasConcept C2908647359 @default.
- W3214501501 hasConcept C42219234 @default.
- W3214501501 hasConcept C61511704 @default.
- W3214501501 hasConcept C71924100 @default.
- W3214501501 hasConcept C90924648 @default.
- W3214501501 hasConcept C99454951 @default.
- W3214501501 hasConceptScore W3214501501C120665830 @default.
- W3214501501 hasConceptScore W3214501501C121332964 @default.
- W3214501501 hasConceptScore W3214501501C126322002 @default.
- W3214501501 hasConceptScore W3214501501C2777170512 @default.
- W3214501501 hasConceptScore W3214501501C2777297131 @default.
- W3214501501 hasConceptScore W3214501501C2780580376 @default.
- W3214501501 hasConceptScore W3214501501C2780852908 @default.
- W3214501501 hasConceptScore W3214501501C2908647359 @default.
- W3214501501 hasConceptScore W3214501501C42219234 @default.
- W3214501501 hasConceptScore W3214501501C61511704 @default.
- W3214501501 hasConceptScore W3214501501C71924100 @default.
- W3214501501 hasConceptScore W3214501501C90924648 @default.
- W3214501501 hasConceptScore W3214501501C99454951 @default.
- W3214501501 hasIssue "5" @default.
- W3214501501 hasLocation W32145015011 @default.
- W3214501501 hasOpenAccess W3214501501 @default.
- W3214501501 hasPrimaryLocation W32145015011 @default.
- W3214501501 hasRelatedWork W1934953066 @default.
- W3214501501 hasRelatedWork W2006582768 @default.
- W3214501501 hasRelatedWork W2022077625 @default.
- W3214501501 hasRelatedWork W2058283066 @default.
- W3214501501 hasRelatedWork W2060817196 @default.
- W3214501501 hasRelatedWork W2064099934 @default.
- W3214501501 hasRelatedWork W2165001714 @default.
- W3214501501 hasRelatedWork W2339046265 @default.
- W3214501501 hasRelatedWork W2366522833 @default.
- W3214501501 hasRelatedWork W2411703057 @default.
- W3214501501 hasRelatedWork W2463500347 @default.
- W3214501501 hasRelatedWork W2531789612 @default.
- W3214501501 hasRelatedWork W2754552921 @default.
- W3214501501 hasRelatedWork W2892102980 @default.
- W3214501501 hasRelatedWork W2992799065 @default.
- W3214501501 hasRelatedWork W3025360726 @default.
- W3214501501 hasRelatedWork W3025369757 @default.
- W3214501501 hasRelatedWork W3105816553 @default.
- W3214501501 hasRelatedWork W3124961106 @default.
- W3214501501 hasRelatedWork W3181816816 @default.
- W3214501501 hasVolume "66" @default.
- W3214501501 isParatext "false" @default.
- W3214501501 isRetracted "false" @default.
- W3214501501 magId "3214501501" @default.
- W3214501501 workType "article" @default.