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- W3214515170 abstract "<h3>Introduction</h3> Sleep disturbance is often reported amongst patients with IBD. Emerging evidence suggests a bidirectional relationship between gut and brain mediated by neuro-immunomodulatory mechanisms. Gastrointestinal symptoms including pain and bowel disturbance that occur in active disease as well as associated psychological stress may thereby impact both sleep quality and quantity. However, few studies have explored sleep in patients with IBD using objective measures such as wrist actigraphy or polysomnography. We, therefore, aimed to systematically review the relevant literature with particular regard to the impact of disease activity on sleep efficiency in IBD patients. <h3>Methods</h3> An electronic search of Medline, EMBASE, Cochrane Library and National Library of Medicine Clinical Trial Database was carried out. Equivalent combinations of keywords relating to ‘Inflammatory Bowel Disease’ and ‘Sleep’ in line with PRISMA guidelines were used to identify studies reporting information on IBD activity and objective measures of sleep. All articles were reviewed individually by two assessors for eligibility and any conflicts were resolved through discussion to reach a final decision. The Oxford CASP tools were utilised to explore risk of bias, study validity and generalisability. Using a fixed-effects model, sleep efficiency data in active and inactive Crohn’s disease patients were pooled and continuous data were summarised. Heterogeneity between studies was assessed by the I<sup>2</sup> statistic as defined by the Cochrane Handbook for Systematic Reviews. <h3>Results</h3> The initial search produced 780 articles. 8 eligible studies were identified and included for qualitative synthesis. 4 of these studies were eligible for quantitative synthesis (meta-analysis), comprising 158 participants (73 with active Crohn’s Disease and 85 patients in remission). 95% CI of two studies in this meta-analysis straddled unity but the overall trend was higher sleep efficiency in remission compared to active Crohn’s (SMD, - 4.60; 95% CI, -7.03, -2.16, p= 0.0002) (Figure.1). Heterogeneity between studies was low (I<sup>2</sup> = 0%, p =0.74). <h3>Conclusions</h3> This meta-analysis reveals CD patients with active disease have a poorer sleep efficiency compared to those in remission but data in UC is lacking. Further work, using objective instruments to assess sleep efficiency, is needed to characterise the interplay between disease activity and sleep quality in IBD." @default.
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- W3214515170 date "2021-11-01" @default.
- W3214515170 modified "2023-09-26" @default.
- W3214515170 title "PMO-8 The relationship between Inflammatory Bowel Disease activity and sleep efficiency: a systematic review and meta-analysis" @default.
- W3214515170 doi "https://doi.org/10.1136/gutjnl-2021-bsg.147" @default.
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