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- W3214552938 abstract "Objective: To assess the immunogenicity and protective efficacy of the DNA vaccine consisting of cholera toxin B subunit(CTB) and polyvalent protective epitopes of Plasmodium falciparum (awte gene) using rhesus monkeys as animal models. Methods: Recombinant plasmids of pCMV CTB AWTE at immunization dose of 500 μg per plasmid per animal were given to five rhesus monkeys three times with two weeks intervals by intramuscle(im) route. Results: High levels of anti CTB and anti malaria epitope antibodies and P.falciparum epitope specific cytotoxic T lymphocyte(CTL) activity were elicited. The animals were challenged with 1.25×10 8 of P.cynomolgi parasites. All monkeys of the control group were imfected for at least 34 days, the DNA vaccinated group was not infected during the 60 days after challenge. Conclusions: The cocktail DNA vaccine which contains multi stage and multi epitope antigen gene shows excellent immunogenicity and protective efficacy,suggesting that DNA vaccine plays an important role in immunization against malaria infection. [" @default.
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- W3214552938 date "2000-01-01" @default.
- W3214552938 modified "2023-09-25" @default.
- W3214552938 title "Induction of protective immune responses in rhesus monkey by immunization with recombinant plasmids of polyvalent epitopes of Plasmodium falciparum using cholera toxin B as adjuvant" @default.
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