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• W3214567939 abstract "The current evidence indicates that inflammation is highly related to depression but not to anxiety in clinical samples. However, less understood is the relationship between inflammation and symptoms of depression and anxiety in a nonclinical sample. The aim of this study was to investigate the association between three inflammation markers and symptoms of depression and anxiety in a healthy sample without a history of psychiatric disorders. Symptoms of depression and anxiety were evaluated in 74 healthy adults (mean age = 42.3; SD = 11.8) using the Hospital Anxiety and Depression Scale. We assessed proinflammatory cytokines (TNF-α, IL-1β, and CRP), and morning cortisol levels using blood samples. TNF-α correlates positively with depressive symptoms, but there were no significant relationships between anxiety scores and inflammation markers. Importantly, TNF-α relates to symptoms of depression independently of anxiety scores, age, body mass index, cortisol, and sex. Our results indicate that TNF-α is associated with depressive symptoms, independently of anxiety, age, body mass index, cortisol, and sex, even in a sample of hospital health professionals without diagnosis or psychiatric history. La evidencia actual indica que la inflamación está altamente relacionada con la depresión pero no con la ansiedad en población clínica. Menos comprendida es la relación entre la inflamación y los síntomas de depresión y ansiedad en población no clínica. El objetivo del estudio fue investigar la asociación entre 3 marcadores de inflamación y síntomas de depresión y ansiedad en adultos sanos sin diagnóstico ni antecedentes psiquiátricos. Se evaluaron los síntomas de depresión y ansiedad en 74 adultos sanos (edad media de 42,3 años; DE = 11,8) utilizando la Escala Hospitalaria de Ansiedad y Depresión. Se evaluaron las citocinas proinflamatorias (TNF-α, IL-1β y PCR) y los niveles de cortisol matutino utilizando muestras de sangre. El TNF-α se correlacionó positivamente con síntomas depresivos, pero no hubo relaciones significativas entre las puntuaciones de ansiedad y los marcadores de inflamación. Es importante destacar que el TNF-α se relaciona con síntomas de depresión, independientemente de las puntuaciones de ansiedad, edad, índice de masa corporal, cortisol y sexo. Nuestros resultados indican que el TNF-α se asocia a síntomas depresivos, independientemente de la ansiedad, edad, índice de masa corporal, cortisol y sexo en una muestra de profesionales de la salud de un hospital sin diagnóstico ni antecedentes psiquiátricos." @default.
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• W3214567939 date "2021-11-01" @default.
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• W3214567939 title "High levels of TNF-α are associated with symptoms of depression in health professionals at a hospital" @default.
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• W3214567939 doi "https://doi.org/10.1016/j.rpsm.2021.10.002" @default.
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