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• W3214604972 abstract "Physical activity and vitamin D receptor (VDR) have been associated with type 2 diabetes mellitus (T2DM). However, the associations of VDR methylation with T2DM and physical activity remained unknown. We aimed to investigate whether VDR methylation was a link between physical activity and T2DM.A 1:1 matching case-control study was designed based on the Henan Rural Cohort Study, including 272 pairs of T2DM patients and nonpatients. Physical activity level was assessed using the International Physical Activity Questionnaire. The high-resolution melt method was applied to determine the methylation level of the promoter region of VDR. The association between physical activity and T2DM was analyzed with a conditional logistic regression model. The effect modification of VDR methylation levels on the association between physical activity and T2DM was conducted. A multivariate correlation analysis model was applied to investigate correlations of VDR methylation with insulin sensitivity.Physical activity level was associated with T2DM risk (crude model: odds ratio [OR] 0.611; 95% CI, 0.416-0.897; adjusted model: OR 0.619; 95% CI, 0.418-0.917). In effect modification analysis, the effects of physical activity on T2DM were stronger for low VDR methylation levels than for high (P = .025). Moreover, VDR methylation levels were associated with insulin (r = -0.089, P = .039) as well as homeostatic model assessment of insulin resistance (r = -0.098, P = .022).The methylation status of the VDR promoter is associated with the secretion and sensitivity of insulin. VDR methylation attenuates the association between physical activity and T2DM, indicating that proactively physical activity may reduce the risk of T2DM, especially in people with low VDR methylation level.背景: 体力活动和维生素D受体(VDR)与2型糖尿病 (T2DM)有关。然而, VDR甲基化与T2DM和体力活动的关系仍然未知。我们旨在研究VDR甲基化是否是体力活动和T2DM之间的连接。 方法: 在河南农村队列研究的基础上设计1:1配对病例对照研究, 包括272对T2DM患者和非糖尿病患者。体力活动水平使用国际体育活动问卷进行评估。应用高分辨率熔融曲线(HRM)测定VDR启动子区的甲基化水平。用条件逻辑回归模型分析体力活动与T2DM的关系。对VDR甲基化水平在体力活动和T2DM之间的联系进行效应修正。应用多元相关分析模型研究VDR甲基化与胰岛素敏感性的相关性。 结果: 体力活动水平与T2DM风险相关(原始模型:OR: 0.611, 95%可信区间:0.416-0.897；校正后模型:OR: 0.619, 95% CI: 0.418-0.917)。在效应修正分析中, 体力活动对T2DM效应的影响在低VDR甲基化水平的个体强于高VDR甲基化水平(P=0.025)。此外, VDR甲基化水平与胰岛素(r=-0.089, P=0.039)以及HOMA-IR(r=-0.098, P=0.022)相关。 结论: VDR启动子甲基化状态与胰岛素的分泌和敏感性有关。VDR甲基化减弱了体力活动和T2DM之间的联系, 表明积极的体力活动可以降低T2DM风险, 尤其是在VDR甲基化水平较低的人群中。." @default.
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• W3214604972 date "2021-12-05" @default.
• W3214604972 modified "2023-10-14" @default.
• W3214604972 title "Vitamin <scp>D</scp> receptor methylation attenuates the association between physical activity and type 2 diabetes mellitus: A case‐control study" @default.
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• W3214604972 doi "https://doi.org/10.1111/1753-0407.13239" @default.
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