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- W3214625435 endingPage "3144" @default.
- W3214625435 startingPage "3144" @default.
- W3214625435 abstract "The activation of microglia, the inflammatory cells of the central nervous system (CNS), has been linked to the pathogenesis of Alzheimer's disease and other neurodegenerative diseases. How microglia sense the changing brain environment, in order to respond appropriately, is still being elucidated. Microglia are able to sense and respond to the mechanical properties of their microenvironment, and the physical and molecular pathways underlying this mechanosensing/mechanotransduction in microglia have recently been investigated. The Hippo pathway functions through mechanosensing and subsequent protein kinase cascades, and is critical for neuronal development and many other cellular processes. In this review, we examine evidence for the potential involvement of Hippo pathway components specifically in microglia in the pathogenesis of Alzheimer's disease. We suggest that the Hippo pathway is worth investigating as a mechanosensing pathway in microglia, and could be one potential therapeutic target pathway for preventing microglial-induced neurodegeneration in AD." @default.
- W3214625435 created "2021-11-22" @default.
- W3214625435 creator A5009419352 @default.
- W3214625435 creator A5023162555 @default.
- W3214625435 creator A5031033738 @default.
- W3214625435 creator A5050984384 @default.
- W3214625435 creator A5059836472 @default.
- W3214625435 creator A5079979947 @default.
- W3214625435 date "2021-11-12" @default.
- W3214625435 modified "2023-10-16" @default.
- W3214625435 title "Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer’s Disease Pathogenesis?" @default.
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