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- W321464041 abstract "Plasma sodium is one of the most commonly measured analytes in laboratory medicine and hyponatraemia is frequently observed, occurring in 15 30% of hospital patients. Severe hyponatraemia is important because of its associated mortality and morbidity risks, and because its treatment also carries the risk of severe morbidity. Nevertheless, it is a complex subject and our understanding of its pathophysiology is incomplete. Although many authors have published in the area there is little in the way of evidence-based guidelines, and, except for part of a recent publication,1 no Australasian guidelines on diagnosis or management that this author could find.In 2007, a panel led by Joseph Verbalis published a review of the diagnosis and modern treatment of hyponatraemia with the title given above.2 While the review was mainly concerned with therapeutic aspects, the pathophysiology and diagnosis of hyponatraemia were extensively discussed as well. It highlighted the role of anti-diuretic hormone (arginine vasopressin, AVP) secretion, appropriate or otherwise, in almost all forms of hyponatraemia, and the possible applications of AVP antagonist therapies in these conditions; in this regard it is noted that the authors declared interests in several pharmaceutical companies developing these treatments. Nevertheless, the diagnostic pathway they advocated was ‘classical’, and the pathophysiology of newer entities was well described. So the question is: are these guidelines likely to help the clinical biochemist grappling with the complexities of hyponatraemia?" @default.
- W321464041 created "2016-06-24" @default.
- W321464041 creator A5085313851 @default.
- W321464041 date "2009-02-01" @default.
- W321464041 modified "2023-09-27" @default.
- W321464041 title "Hyponatremia treatment guidelines 2007: expert panel recommendations." @default.
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