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- W3214645136 abstract "We report a rare B/T/myeloid MPAL case with MLL-AF4 gene rearrangement, successfully treated with an AML-oriented protocol, after failing leukemic blast clearing as a result of pre-phase steroid treatment. MPAL diagnosis is based on the combined expression of lymphoid, either B- or T-, and myeloid markers, potentially showing a B/T lymphoid, B/myeloid, T/myeloid, or even and more rarely, a trilineage B/T/myeloid commitment. A 34-year-old Palestinian social worker was admitted at the Augusta Victoria Hospital on September 2018 because of pancytopenia, multiple bluish-to-purple skin lesions, gingival bleeding, fever and night sweats. The patient was readmitted two weeks later for consolidation chemotherapy with high dose cytarabine (HIDAC) 3000 mg/m2 days 1, 3, and 5. ALL- oriented chemotherapy has been reported to be a superior treatment, steroid response could guide to switching to an AML-based protocol." @default.
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- W3214645136 date "2021-10-29" @default.
- W3214645136 modified "2023-09-24" @default.
- W3214645136 title "A Case Report on Diagnostic, Genetic and Therapeutic Challenges in Mixed Phenotype Acute Leukemia" @default.
- W3214645136 doi "https://doi.org/10.9734/bpi/rdmmr/v9/4037f" @default.
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