FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214657817> ?p ?o ?g. }

• W3214657817 abstract "During acute heart failure (HF), remote ischemic conditioning (RIC) has proven to be beneficial; however, it is currently unclear whether it also extends benefits from chronic congestive, cardiopulmonary heart failure (CHF). Previous studies from our laboratory have shown three phases describing CHF viz. (1) HF with preserved ejection fraction (HFpEF), (2) HF with reduced EF (HFrEF), and (3) HF with reversed EF. Although reciprocal organ interaction, ablation of sympathetic, and calcium signaling genes are associated with HFpEF to HFrEF, the mechanism is unclear. The HFrEF ensues, in part, due to reduced angiogenesis, coronary reserve, and leakage of endocardial endothelial (EE) and finally breakdown of the blood-heart barrier (BHB) integrity. In fact, our hypothesis states that a change in phenotype from compensatory HFpEF to decompensatory HFrEF is determined by a potential decrease in regenerative, proangiogenic factors along with a concomitant increase in epigenetic memory, inflammation that combinedly causes oxidative, and proteolytic stress response. To test this hypothesis, we created CHF by aorta-vena-cava (AV) fistula in a group of mice that were subsequently treated with that of hind-limb RIC. HFpEF vs. HFrEF transition was determined by serial/longitudinal echo measurements. Results revealed an increase in skeletal muscle musclin contents, bone-marrow (CD71), and sympathetic activation (β2-AR) by RIC. We also observed a decrease in vascular density and attenuation of EE-BHB function due to a corresponding increase in the activity of MMP-2, vascular endothelial growth factor (VEGF), caspase, and calpain. This decrease was successfully mitigated by RIC-released skeletal muscle exosomes that contain musclin, the myokine along with bone marrow, and sympathetic activation. In short, based on proteome (omics) analysis, ∼20 proteins that appear to be involved in signaling pathways responsible for the synthesis, contraction, and relaxation of cardiac muscle were found to be the dominant features. Thus, our results support that the CHF phenotype causes dysfunction of cardiac metabolism, its contraction, and relaxation. Interestingly, RIC was able to mitigate many of the deleterious changes, as revealed by our multi-omics findings." @default.
• W3214657817 created "2021-11-22" @default.
• W3214657817 creator A5003454740 @default.
• W3214657817 creator A5009434872 @default.
• W3214657817 creator A5036202489 @default.
• W3214657817 creator A5061448601 @default.
• W3214657817 creator A5087487562 @default.
• W3214657817 date "2021-11-11" @default.
• W3214657817 modified "2023-10-13" @default.
• W3214657817 title "Remote Hind-Limb Ischemia Mechanism of Preserved Ejection Fraction During Heart Failure" @default.
• W3214657817 cites W18175151 @default.
• W3214657817 cites W1969958827 @default.
• W3214657817 cites W1970492670 @default.
• W3214657817 cites W1991774783 @default.
• W3214657817 cites W2012517632 @default.
• W3214657817 cites W2018687481 @default.
• W3214657817 cites W2019456646 @default.
• W3214657817 cites W2027484414 @default.
• W3214657817 cites W2031466941 @default.
• W3214657817 cites W2040899667 @default.
• W3214657817 cites W2052860570 @default.
• W3214657817 cites W2067140446 @default.
• W3214657817 cites W2070501506 @default.
• W3214657817 cites W2072740783 @default.
• W3214657817 cites W2079617651 @default.
• W3214657817 cites W2085268543 @default.
• W3214657817 cites W2091394830 @default.
• W3214657817 cites W2125660933 @default.
• W3214657817 cites W2127999958 @default.
• W3214657817 cites W2128654660 @default.
• W3214657817 cites W2140259329 @default.
• W3214657817 cites W2144445866 @default.
• W3214657817 cites W2150411170 @default.
• W3214657817 cites W2221507346 @default.
• W3214657817 cites W2275786821 @default.
• W3214657817 cites W2328489436 @default.
• W3214657817 cites W2510644495 @default.
• W3214657817 cites W2542825346 @default.
• W3214657817 cites W2547378099 @default.
• W3214657817 cites W2802715752 @default.
• W3214657817 cites W2886817845 @default.
• W3214657817 cites W2890203796 @default.
• W3214657817 cites W2890744640 @default.
• W3214657817 cites W2944472943 @default.
• W3214657817 cites W2947162386 @default.
• W3214657817 cites W2971554710 @default.
• W3214657817 cites W3046206982 @default.
• W3214657817 cites W3092500182 @default.
• W3214657817 cites W3124401787 @default.
• W3214657817 cites W3124991957 @default.
• W3214657817 cites W3130118028 @default.
• W3214657817 cites W3158507003 @default.
• W3214657817 cites W4231734024 @default.
• W3214657817 cites W5611105 @default.
• W3214657817 doi "https://doi.org/10.3389/fphys.2021.745328" @default.
• W3214657817 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8632236" @default.
• W3214657817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34858202" @default.
• W3214657817 hasPublicationYear "2021" @default.
• W3214657817 type Work @default.
• W3214657817 sameAs 3214657817 @default.
• W3214657817 citedByCount "6" @default.
• W3214657817 countsByYear W32146578172022 @default.
• W3214657817 countsByYear W32146578172023 @default.
• W3214657817 crossrefType "journal-article" @default.
• W3214657817 hasAuthorship W3214657817A5003454740 @default.
• W3214657817 hasAuthorship W3214657817A5009434872 @default.
• W3214657817 hasAuthorship W3214657817A5036202489 @default.
• W3214657817 hasAuthorship W3214657817A5061448601 @default.
• W3214657817 hasAuthorship W3214657817A5087487562 @default.
• W3214657817 hasBestOaLocation W32146578171 @default.
• W3214657817 hasConcept C126322002 @default.
• W3214657817 hasConcept C164705383 @default.
• W3214657817 hasConcept C2777099384 @default.
• W3214657817 hasConcept C2778198053 @default.
• W3214657817 hasConcept C2778259205 @default.
• W3214657817 hasConcept C2779959927 @default.
• W3214657817 hasConcept C71924100 @default.
• W3214657817 hasConcept C78085059 @default.
• W3214657817 hasConceptScore W3214657817C126322002 @default.
• W3214657817 hasConceptScore W3214657817C164705383 @default.
• W3214657817 hasConceptScore W3214657817C2777099384 @default.
• W3214657817 hasConceptScore W3214657817C2778198053 @default.
• W3214657817 hasConceptScore W3214657817C2778259205 @default.
• W3214657817 hasConceptScore W3214657817C2779959927 @default.
• W3214657817 hasConceptScore W3214657817C71924100 @default.
• W3214657817 hasConceptScore W3214657817C78085059 @default.
• W3214657817 hasFunder F4320332161 @default.
• W3214657817 hasLocation W32146578171 @default.
• W3214657817 hasLocation W32146578172 @default.
• W3214657817 hasLocation W32146578173 @default.
• W3214657817 hasLocation W32146578174 @default.
• W3214657817 hasOpenAccess W3214657817 @default.
• W3214657817 hasPrimaryLocation W32146578171 @default.
• W3214657817 hasRelatedWork W1971710084 @default.
• W3214657817 hasRelatedWork W2011390101 @default.
• W3214657817 hasRelatedWork W2028196543 @default.
• W3214657817 hasRelatedWork W2072108749 @default.
• W3214657817 hasRelatedWork W2481234813 @default.
• W3214657817 hasRelatedWork W2891746874 @default.
• W3214657817 hasRelatedWork W2920829402 @default.

• next