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- W3214678045 endingPage "73" @default.
- W3214678045 startingPage "47" @default.
- W3214678045 abstract "Covalent labeling of amino acid residues has emerged as a significant protocol in both medicinal chemistry and chemical biology applications in the last decades. In this chapter, we focus on those functional groups, so called warheads that form covalent bonds with the targeted amino acid side chains in proteins. We discuss the residues targeted by more than a hundred functional groups, together with their reported selectivity, reactivity and labeling mechanism. The collection of relevant literature is up to date until first May 2020. From this compilation one can conclude that there are available targets with only a few reported warheads, thus the discovery of new chemistries could contribute to the suitable labeling with a wider selection of functional groups. In addition, this wide landscape of warheads enables choosing the appropriate one and tailoring the functionality to the amino acid targeted as an efficient and selective methodology." @default.
- W3214678045 created "2021-11-22" @default.
- W3214678045 creator A5011278193 @default.
- W3214678045 creator A5022888378 @default.
- W3214678045 date "2022-01-01" @default.
- W3214678045 modified "2023-10-18" @default.
- W3214678045 title "Warheads for designing covalent inhibitors and chemical probes" @default.
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