FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214689455> ?p ?o ?g. }

• W3214689455 abstract "Abstract Background The cardioprotective ability of n-3 polyunsaturated fatty acids (PUFAs) is controversial. Most studies suggest a specific role for PUFAs in cardioprotection from ischemic heart disease (IHD). However, few studies have used genetic biomarkers of n-3 PUFAs to examine their potential relationships with IHD. This study aimed to use Mendelian randomization to evaluate whether genetically-predicted n-3 PUFAs affect IHD and cardiometabolic risk factors (CRFs). Methods Genetic variants strongly ( p < 5 × 10 –8 ) and independently ( r 2 > 0.1) associated with n-3 PUFAs were derived from the CHARGE Consortium (including 8,866 subjects of European ancestry) and were used as instrumental variables (IVs) for evaluating the effect of n-3 PUFAs, including α-linolenic acid (ALA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). Data on the associations between the IVs and IHD, myocardial infarction, and CRFs (including diabetes, lipids, blood pressure, body mass index, and waist-to-hip ratio (WHR)) were obtained from the UK Biobank SOFT CAD GWAS with the CARDIoGRAMplusC4D 1000 Genomes-based GWAS (113,937 IHD cases and 339,115 controls), the Myocardial Infarction Genetics and CARDIoGRAM Exome consortia (42,335 MI cases and 78,240 controls), the DIAbetes Genetics Replication And Meta-analysis consortium (26,676 diabetes mellitus cases and 132,532 controls), the Global Lipids Genetics Consortium (n = 196,475), the International Consortium for Blood Pressure (n = 69,395), and the meta-analysis of GWAS for body fat distribution in the UK Biobank and Genetic Investigation of Anthropometric Traits (n = 694,649). Results Genetically-predicted higher ALA was associated with lower risk of IHD, type 2 diabetes (T2D), and lower serum lipids. The effect size per 0.05-unit increase (about 1 standard deviation) in plasma ALA level) was − 1.173 (95% confidence interval − 2.214 to − 0.133) for IHD. DPA and EPA had no association with IHD but were associated with a higher risk of T2D, higher levels of lipids or WHR. DHA had no association with IHD or CRFs. Conclusions Our study suggests a benefit of ALA for IHD and its main risk factors. DHA, DPA, and EPA had no association with IHD but were partly associated with increasing cardiometabolic risk factors." @default.
• W3214689455 created "2021-11-22" @default.
• W3214689455 creator A5022815488 @default.
• W3214689455 creator A5058567155 @default.
• W3214689455 creator A5066325475 @default.
• W3214689455 creator A5084082972 @default.
• W3214689455 date "2021-11-08" @default.
• W3214689455 modified "2023-10-03" @default.
• W3214689455 title "Effect of n-3 polyunsaturated fatty acids on ischemic heart disease and cardiometabolic risk factors: a two-sample Mendelian randomization study" @default.
• W3214689455 cites W1866441262 @default.
• W3214689455 cites W1978718896 @default.
• W3214689455 cites W1995520713 @default.
• W3214689455 cites W2025624210 @default.
• W3214689455 cites W2093664978 @default.
• W3214689455 cites W2097695579 @default.
• W3214689455 cites W2099294505 @default.
• W3214689455 cites W2101605059 @default.
• W3214689455 cites W2106319388 @default.
• W3214689455 cites W2108948907 @default.
• W3214689455 cites W2112093807 @default.
• W3214689455 cites W2116205322 @default.
• W3214689455 cites W2118743532 @default.
• W3214689455 cites W2127768736 @default.
• W3214689455 cites W2153118028 @default.
• W3214689455 cites W2166320441 @default.
• W3214689455 cites W2238851414 @default.
• W3214689455 cites W2272260015 @default.
• W3214689455 cites W2324862792 @default.
• W3214689455 cites W2469860611 @default.
• W3214689455 cites W2488282410 @default.
• W3214689455 cites W2587110638 @default.
• W3214689455 cites W2587804655 @default.
• W3214689455 cites W2597054569 @default.
• W3214689455 cites W2614282478 @default.
• W3214689455 cites W2614566443 @default.
• W3214689455 cites W2617316722 @default.
• W3214689455 cites W2735404270 @default.
• W3214689455 cites W2759498253 @default.
• W3214689455 cites W2782160467 @default.
• W3214689455 cites W2785975902 @default.
• W3214689455 cites W2794106871 @default.
• W3214689455 cites W2799855210 @default.
• W3214689455 cites W2803072880 @default.
• W3214689455 cites W2803843936 @default.
• W3214689455 cites W2809820001 @default.
• W3214689455 cites W2899669642 @default.
• W3214689455 cites W2899720772 @default.
• W3214689455 cites W2899997727 @default.
• W3214689455 cites W2900151286 @default.
• W3214689455 cites W2903552924 @default.
• W3214689455 cites W2909069259 @default.
• W3214689455 cites W2916248238 @default.
• W3214689455 cites W2923358581 @default.
• W3214689455 cites W2943392274 @default.
• W3214689455 cites W2952686929 @default.
• W3214689455 cites W2965031191 @default.
• W3214689455 cites W2969523838 @default.
• W3214689455 cites W2972340070 @default.
• W3214689455 cites W2976844203 @default.
• W3214689455 cites W2982395068 @default.
• W3214689455 cites W2991427633 @default.
• W3214689455 cites W2999479781 @default.
• W3214689455 cites W2999576140 @default.
• W3214689455 cites W3008628124 @default.
• W3214689455 cites W3103257019 @default.
• W3214689455 cites W3104764004 @default.
• W3214689455 cites W3124296889 @default.
• W3214689455 doi "https://doi.org/10.1186/s12872-021-02342-6" @default.
• W3214689455 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8576934" @default.
• W3214689455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34749668" @default.
• W3214689455 hasPublicationYear "2021" @default.
• W3214689455 type Work @default.
• W3214689455 sameAs 3214689455 @default.
• W3214689455 citedByCount "6" @default.
• W3214689455 countsByYear W32146894552022 @default.
• W3214689455 countsByYear W32146894552023 @default.
• W3214689455 crossrefType "journal-article" @default.
• W3214689455 hasAuthorship W3214689455A5022815488 @default.
• W3214689455 hasAuthorship W3214689455A5058567155 @default.
• W3214689455 hasAuthorship W3214689455A5066325475 @default.
• W3214689455 hasAuthorship W3214689455A5084082972 @default.
• W3214689455 hasBestOaLocation W32146894551 @default.
• W3214689455 hasConcept C104317684 @default.
• W3214689455 hasConcept C106208931 @default.
• W3214689455 hasConcept C126322002 @default.
• W3214689455 hasConcept C134018914 @default.
• W3214689455 hasConcept C135763542 @default.
• W3214689455 hasConcept C148257392 @default.
• W3214689455 hasConcept C153209595 @default.
• W3214689455 hasConcept C164705383 @default.
• W3214689455 hasConcept C19038510 @default.
• W3214689455 hasConcept C2776091944 @default.
• W3214689455 hasConcept C2777171753 @default.
• W3214689455 hasConcept C2779901538 @default.
• W3214689455 hasConcept C2780221984 @default.
• W3214689455 hasConcept C2781349093 @default.
• W3214689455 hasConcept C2993967602 @default.
• W3214689455 hasConcept C500558357 @default.
• W3214689455 hasConcept C543025807 @default.
• W3214689455 hasConcept C54355233 @default.

• next