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• W3214722383 abstract "Alcohol dependence (AD) is a condition of alcohol use disorder in which the drinkers frequently develop emotional symptoms associated with a continuous alcohol intake. AD characterized by metabolic disturbances can be quantitatively analyzed by metabolomics to identify the alterations in metabolic pathways. This study aimed to: i) compare the plasma metabolic profiling between healthy and AD-diagnosed individuals to reveal the altered metabolic profiles in AD, and ii) identify potential biological correlates of alcohol-dependent inpatients based on metabolomics and interpretable machine learning. Plasma samples were obtained from healthy (n = 42) and AD-diagnosed individuals (n = 43). The plasma metabolic differences between them were investigated using liquid chromatography-tandem mass spectrometry (AB SCIEX® QTRAP 4500 system) in different electrospray ionization modes with scheduled multiple reaction monitoring scans. In total, 59 and 52 compounds were semi-quantitatively measured in positive and negative ionization modes, respectively. In addition, 39 metabolites were identified as important variables to contribute to the classifications using an orthogonal partial least squares-discriminant analysis (OPLS-DA) (VIP > 1) and also significantly different between healthy and AD-diagnosed individuals using univariate analysis (p-value < 0.05 and false discovery rate < 0.05). Among the identified metabolites, indole-3-carboxylic acid, quinolinic acid, hydroxy-tryptophan, and serotonin were involved in the tryptophan metabolism along the indole, kynurenine, and serotonin pathways. Metabolic pathway analysis revealed significant changes or imbalances in alanine, aspartate, glutamate metabolism, which was possibly the main altered pathway related to AD. Tryptophan metabolism interactively influenced other metabolic pathways, such as nicotinate and nicotinamide metabolism. Furthermore, among the OPLS-DA-identified metabolites, normetanephrine and ascorbic acid were demonstrated as suitable biological correlates of AD inpatients from our model using an interpretable, supervised decision tree classifier algorithm. These findings indicate that the discriminatory metabolic profiles between healthy and AD-diagnosed individuals may benefit researchers in illustrating the underlying molecular mechanisms of AD. This study also highlights the approach of combining metabolomics and interpretable machine learning as a valuable tool to uncover potential biological correlates. Future studies should focus on the global analysis of the possible roles of these differential metabolites and disordered metabolic pathways in the pathophysiology of AD." @default.
• W3214722383 created "2021-11-22" @default.
• W3214722383 creator A5005655977 @default.
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• W3214722383 date "2021-11-08" @default.
• W3214722383 modified "2023-09-27" @default.
• W3214722383 title "Combining Metabolomics and Interpretable Machine Learning to Reveal Plasma Metabolic Profiling and Biological Correlates of Alcohol-Dependent Inpatients: What About Tryptophan Metabolism Regulation?" @default.
• W3214722383 cites W1552868894 @default.
• W3214722383 cites W1743561755 @default.
• W3214722383 cites W1920018418 @default.
• W3214722383 cites W1969763801 @default.
• W3214722383 cites W1970316597 @default.
• W3214722383 cites W1977067570 @default.
• W3214722383 cites W1982185581 @default.
• W3214722383 cites W1984053258 @default.
• W3214722383 cites W1984299054 @default.
• W3214722383 cites W1992483596 @default.
• W3214722383 cites W1996111529 @default.
• W3214722383 cites W2001639140 @default.
• W3214722383 cites W2003701387 @default.
• W3214722383 cites W2011226144 @default.
• W3214722383 cites W2019482289 @default.
• W3214722383 cites W2026245891 @default.
• W3214722383 cites W2035483241 @default.
• W3214722383 cites W2043063479 @default.
• W3214722383 cites W2044238207 @default.
• W3214722383 cites W2048712500 @default.
• W3214722383 cites W2084331785 @default.
• W3214722383 cites W2089016636 @default.
• W3214722383 cites W2090520944 @default.
• W3214722383 cites W2090931660 @default.
• W3214722383 cites W2098508105 @default.
• W3214722383 cites W2115430420 @default.
• W3214722383 cites W2123808389 @default.
• W3214722383 cites W2131557693 @default.
• W3214722383 cites W2133612797 @default.
• W3214722383 cites W2135983376 @default.
• W3214722383 cites W2139226042 @default.
• W3214722383 cites W2144658154 @default.
• W3214722383 cites W2152299235 @default.
• W3214722383 cites W2268699998 @default.
• W3214722383 cites W2271119201 @default.
• W3214722383 cites W2301389244 @default.
• W3214722383 cites W2335560976 @default.
• W3214722383 cites W2395407533 @default.
• W3214722383 cites W2434958496 @default.
• W3214722383 cites W2461522970 @default.
• W3214722383 cites W2472540328 @default.
• W3214722383 cites W2512340875 @default.
• W3214722383 cites W2538413746 @default.
• W3214722383 cites W2593300139 @default.
• W3214722383 cites W2598379118 @default.
• W3214722383 cites W2602759662 @default.
• W3214722383 cites W2618884689 @default.
• W3214722383 cites W2621945583 @default.
• W3214722383 cites W2768689149 @default.
• W3214722383 cites W2792042705 @default.
• W3214722383 cites W2802254242 @default.
• W3214722383 cites W2805252212 @default.
• W3214722383 cites W2807728333 @default.
• W3214722383 cites W2896920177 @default.
• W3214722383 cites W2898070662 @default.
• W3214722383 cites W2903735418 @default.
• W3214722383 cites W2912536857 @default.
• W3214722383 cites W2915534298 @default.
• W3214722383 cites W2920679031 @default.
• W3214722383 cites W2920891429 @default.
• W3214722383 cites W2938876428 @default.
• W3214722383 cites W2939948226 @default.
• W3214722383 cites W2947487764 @default.
• W3214722383 cites W2951691646 @default.
• W3214722383 cites W2957986133 @default.
• W3214722383 cites W2971235367 @default.
• W3214722383 cites W2982488225 @default.
• W3214722383 cites W2990882070 @default.
• W3214722383 cites W2993335305 @default.
• W3214722383 cites W2994798139 @default.
• W3214722383 cites W2994898777 @default.
• W3214722383 cites W2999612700 @default.
• W3214722383 cites W3003468827 @default.
• W3214722383 cites W3006301284 @default.
• W3214722383 cites W3012489703 @default.
• W3214722383 cites W3020884144 @default.
• W3214722383 cites W3026037716 @default.
• W3214722383 cites W3034396232 @default.
• W3214722383 cites W3036015283 @default.
• W3214722383 cites W3049502358 @default.
• W3214722383 cites W3092614520 @default.
• W3214722383 cites W3094346505 @default.
• W3214722383 cites W3095047659 @default.
• W3214722383 cites W3107508539 @default.
• W3214722383 cites W3107747122 @default.

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