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- W3214730896 endingPage "445" @default.
- W3214730896 startingPage "445" @default.
- W3214730896 abstract "Multicellular tumor spheroids (MCTs) have been employed in biomedical fields owing to their advantage in designing a three-dimensional (3D) solid tumor model. For controlling multicellular cancer spheroids, mimicking the tumor extracellular matrix (ECM) microenvironment is important to understand cell-cell and cell-matrix interactions. In drug cytotoxicity assessments, MCTs provide better mimicry of conventional solid tumors that can precisely represent anticancer drug candidates' effects. To generate incubate multicellular spheroids, researchers have developed several 3D multicellular spheroid culture technologies to establish a research background and a platform using tumor modelingvia advanced materials science, and biosensing techniques for drug-screening. In application, drug screening was performed in both invasive and non-invasive manners, according to their impact on the spheroids. Here, we review the trend of 3D spheroid culture technology and culture platforms, and their combination with various biosensing techniques for drug screening in the biomedical field." @default.
- W3214730896 created "2021-11-22" @default.
- W3214730896 creator A5035936668 @default.
- W3214730896 creator A5051911557 @default.
- W3214730896 date "2021-11-11" @default.
- W3214730896 modified "2023-10-14" @default.
- W3214730896 title "Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening" @default.
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