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- W3214776680 endingPage "57" @default.
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- W3214776680 abstract "Intron recognition in the spotlight Excision of noncoding introns from pre–messenger RNAs is catalyzed by the spliceosome, a large RNA-protein complex that recognizes specific sequences at the exon-intron boundaries (splice sites). These sequences are highly degenerate in humans, and it has remained elusive how they are recognized by the spliceosome. Tholen et al . report a series of high-resolution structures of the human U2 small nucleolar ribonucleoprotein, the component of the spliceosome that recognizes branch sites. The structures explain how SF3B6 helps to stabilize the branch helix in the absence of extensive sequence complementarity. A newly identified spliceosome assembly intermediate suggests a mechanism for fidelity control of branch site recognition. —DJ" @default.
- W3214776680 created "2021-12-06" @default.
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- W3214776680 date "2022-01-07" @default.
- W3214776680 modified "2023-10-16" @default.
- W3214776680 title "Structural basis of branch site recognition by the human spliceosome" @default.
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- W3214776680 doi "https://doi.org/10.1126/science.abm4245" @default.
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