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- W3214790250 abstract "Prostaglandin E2 (PGE2) is a lipid mediator derived from the fatty acid arachidonic acid. As an essential inflammatory factor, PGE2 has a critical impact on immune regulation through the prostanoid E (EP) receptor pathway. T cells, including CD4+ and CD8+ T cell subsets, play crucial roles in the adaptive immune response. Previous studies have shown that PGE2 is involved in regulating CD4+ T cell differentiation and inflammatory cytokine production via the EP receptor pathway, thereby affecting the development of diseases mediated by CD4+ T cells. In this review, we summarize the signaling pathway of PGE2 and describe the relationship between PGE2 and T cell differentiation. Hence, this review may provide important evidence for immune therapies and may even promote the development of biomedicines." @default.
- W3214790250 created "2021-12-06" @default.
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- W3214790250 date "2021-11-26" @default.
- W3214790250 modified "2023-10-18" @default.
- W3214790250 title "The Signaling Pathway of PGE2 and Its Regulatory Role in T Cell Differentiation" @default.
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- W3214790250 doi "https://doi.org/10.1155/2021/9087816" @default.
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