FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214847105> ?p ?o ?g. }

• W3214847105 endingPage "e0260252" @default.
• W3214847105 startingPage "e0260252" @default.
• W3214847105 abstract "High grade glioma is one of the deadliest human cancers with a median survival rate of only one year following diagnosis. The highly motile and invasive nature of high grade glioma makes it difficult to completely remove surgically. Therefore, increasing our knowledge of the mechanisms glioma cells use to invade normal brain is of critical importance in designing novel therapies. It was previously shown by our laboratory that tumor-associated microglia (TAMs) stimulate glioma cell invasion and this process is dependent on CSF-1R signaling. In this study, we seek to identify pro-invasive factors that are upregulated in microglia in a CSF-1R-dependent manner. We assayed cDNA and protein from microglia treated with conditioned media from the murine glioma cell line GL261, and discovered that several EGFR ligands including amphiregulin (AREG) are strongly upregulated. This upregulation is blocked by addition of a pharmacological CSF-1R inhibitor. Using RNA interference, we show that AREG-depleted microglia are less effective at promoting invasion of GL261 cells into Matrigel-coated invasion chambers. In addition, an AREG blocking antibody strongly attenuates the ability of THP-1 macrophages to activate human glioma cell line U87 invasion. Furthermore, we have identified a signaling pathway which involves CSF-1 signaling through ERK to upregulate AREG expression in microglia. Interfering with ERK using pharmacological inhibitors prevents AREG upregulation in microglia and microglia-stimulated GL261 invasion. These data highlight AREG as a key factor in produced by tumor associated microglia in promoting glioma invasion." @default.
• W3214847105 created "2021-12-06" @default.
• W3214847105 creator A5084225673 @default.
• W3214847105 creator A5091538279 @default.
• W3214847105 date "2021-11-29" @default.
• W3214847105 modified "2023-10-13" @default.
• W3214847105 title "Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin" @default.
• W3214847105 cites W1506672302 @default.
• W3214847105 cites W1571339913 @default.
• W3214847105 cites W1967698512 @default.
• W3214847105 cites W1973469864 @default.
• W3214847105 cites W1974186507 @default.
• W3214847105 cites W1974223809 @default.
• W3214847105 cites W1980485314 @default.
• W3214847105 cites W1982626083 @default.
• W3214847105 cites W1985772559 @default.
• W3214847105 cites W1992913621 @default.
• W3214847105 cites W2000217512 @default.
• W3214847105 cites W2008134464 @default.
• W3214847105 cites W2008264147 @default.
• W3214847105 cites W2011682148 @default.
• W3214847105 cites W2014436445 @default.
• W3214847105 cites W2016497607 @default.
• W3214847105 cites W2022685199 @default.
• W3214847105 cites W2026375113 @default.
• W3214847105 cites W2027678100 @default.
• W3214847105 cites W2048898424 @default.
• W3214847105 cites W2050655043 @default.
• W3214847105 cites W2051408106 @default.
• W3214847105 cites W2051910121 @default.
• W3214847105 cites W2056403357 @default.
• W3214847105 cites W2063508984 @default.
• W3214847105 cites W2066209685 @default.
• W3214847105 cites W2066569577 @default.
• W3214847105 cites W2069415454 @default.
• W3214847105 cites W2076327296 @default.
• W3214847105 cites W2079913429 @default.
• W3214847105 cites W2080552153 @default.
• W3214847105 cites W2081978376 @default.
• W3214847105 cites W2093005409 @default.
• W3214847105 cites W2098976891 @default.
• W3214847105 cites W2109816625 @default.
• W3214847105 cites W2111354523 @default.
• W3214847105 cites W2113462579 @default.
• W3214847105 cites W2127079528 @default.
• W3214847105 cites W2127094853 @default.
• W3214847105 cites W2127179825 @default.
• W3214847105 cites W2127981279 @default.
• W3214847105 cites W2129018264 @default.
• W3214847105 cites W2139708381 @default.
• W3214847105 cites W2146062596 @default.
• W3214847105 cites W2147241956 @default.
• W3214847105 cites W2147328758 @default.
• W3214847105 cites W2151575024 @default.
• W3214847105 cites W2151859384 @default.
• W3214847105 cites W2159506617 @default.
• W3214847105 cites W2164338061 @default.
• W3214847105 cites W2271723211 @default.
• W3214847105 cites W2401143451 @default.
• W3214847105 cites W2511292374 @default.
• W3214847105 cites W2535798030 @default.
• W3214847105 cites W2590076094 @default.
• W3214847105 cites W2604129195 @default.
• W3214847105 cites W2625848096 @default.
• W3214847105 cites W2763129844 @default.
• W3214847105 cites W2766326897 @default.
• W3214847105 cites W2774488891 @default.
• W3214847105 cites W2781438702 @default.
• W3214847105 cites W2781860009 @default.
• W3214847105 cites W2783146090 @default.
• W3214847105 cites W2794422249 @default.
• W3214847105 cites W2797203065 @default.
• W3214847105 cites W2896143978 @default.
• W3214847105 cites W2898229107 @default.
• W3214847105 cites W2903084459 @default.
• W3214847105 cites W2982924140 @default.
• W3214847105 cites W2989776766 @default.
• W3214847105 cites W3022913886 @default.
• W3214847105 doi "https://doi.org/10.1371/journal.pone.0260252" @default.
• W3214847105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8629255" @default.
• W3214847105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34843542" @default.
• W3214847105 hasPublicationYear "2021" @default.
• W3214847105 type Work @default.
• W3214847105 sameAs 3214847105 @default.
• W3214847105 citedByCount "7" @default.
• W3214847105 countsByYear W32148471052022 @default.
• W3214847105 countsByYear W32148471052023 @default.
• W3214847105 crossrefType "journal-article" @default.
• W3214847105 hasAuthorship W3214847105A5084225673 @default.
• W3214847105 hasAuthorship W3214847105A5091538279 @default.
• W3214847105 hasBestOaLocation W32148471051 @default.
• W3214847105 hasConcept C104317684 @default.
• W3214847105 hasConcept C127561419 @default.
• W3214847105 hasConcept C128473837 @default.
• W3214847105 hasConcept C185592680 @default.
• W3214847105 hasConcept C203014093 @default.
• W3214847105 hasConcept C2776362946 @default.
• W3214847105 hasConcept C2776914184 @default.

• next