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- W3214880191 abstract "Auditory transduction is mediated by chordotonal (Cho) neurons in Drosophila larvae, but the molecular identity of the mechanotransduction (MET) channel is elusive. Here, we established a whole-cell recording system of Cho neurons and showed that two transient receptor potential vanilloid (TRPV) channels, Nanchung (NAN) and Inactive (IAV), are essential for MET currents in Cho neurons. NAN and IAV form active ion channels when expressed simultaneously in S2 cells. Point mutations in the pore region of NAN-IAV change the reversal potential of the MET currents. Particularly, residues 857 through 990 in the IAV carboxyl terminus regulate the kinetics of MET currents in Cho neurons. In addition, TRPN channel NompC contributes to the adaptation of auditory transduction currents independent of its ion-conduction function. These results indicate that NAN-IAV, rather than NompC, functions as essential pore-forming subunits of the native auditory transduction channel in Drosophila and provide insights into the gating mechanism of MET currents in Cho neurons." @default.
- W3214880191 created "2021-12-06" @default.
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- W3214880191 date "2021-11-30" @default.
- W3214880191 modified "2023-10-01" @default.
- W3214880191 title "Nanchung and Inactive define pore properties of the native auditory transduction channel in <i>Drosophila</i>" @default.
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- W3214880191 doi "https://doi.org/10.1073/pnas.2106459118" @default.
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