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- W3214903531 abstract "Schwann cells, the main glial cell in the peripheral nervous system (PNS), ensheath bundles of small unmyelinated axons or form myelin on larger axons. PNS injuries initiate transcriptional reprograming in both Schwann cells and sensory neurons that promotes regeneration. While the factors that initiate the transcriptional reprograming in Schwann cells are well characterized, the full range of stimuli that initiate this reprograming in sensory neurons remain elusive. Here, using a genetic model of Schwann cell ablation, we find that Schwann cell loss results in transient PNS demyelination without overt axonal loss. By profiling sensory ganglia at single-cell resolution we show that this demyelination induces transcriptional reprogramming preferably in proprioceptive and Aβ RA-LTMR neurons. Transcriptional reprogramming is assumed to be a cell-autonomous response of sensory neurons to mechanical axonal injury. By identifying similar reprogramming in non-injured, demyelinated neurons, our study suggests that this reprogramming represents a non-cell-autonomous transcriptional response of sensory neurons to the loss of axon-Schwann cell interactions." @default.
- W3214903531 created "2021-12-06" @default.
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- W3214903531 date "2021-11-23" @default.
- W3214903531 modified "2023-09-26" @default.
- W3214903531 title "Demyelination induces transcriptional reprogramming in proprioceptive and Aβ rapidly adapting low-threshold-mechanoreceptor neurons." @default.
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- W3214903531 doi "https://doi.org/10.1101/2021.11.23.469748" @default.
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