FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214908802> ?p ?o ?g. }

• W3214908802 abstract "Protein S (PS; encoded by the PROS1 gene), a key vitamin K-dependent anticoagulant protein, is emerging as a key structural and functional protein that is overexpressd in various malignancies, but how PS signals to promote lung cancer progression is unclear.We used immortalized, nontumorigenic human lung epithelial cell line NL-20, A549 cells as experimental cellular models for lung cancer, and human microvascular endothelial cells (HMEC-1) as a model system for angiogenesis. A loss- and gain-of-function approach was then used to analyze the role of tumor-derived PS and their natural TAM receptors Tyro3 and MerTK in regulating cell proliferation, migration, anchorage-independent growth, and capillary-like tube formation, all prominent attributes of the metastatic phenotype of tumor cells.Evidence is now provided that regulation of PROS1 gene expression using either stable cell lines expressing lentiviral-short hairpin RNA (shRNAs) or a replication-incompetent adenovirus alters the phosphorylation of several major signaling pathways, including Erk, PKB/Akt, p38, and focal adhesion kinase (FAK), and modulates PS-dependent Tyro3- and MerTK-mediated cell migration, proliferation, and anchorage-independent growth of lung cancer cells, and endothelial cell capillary-like tube formation.These finding suggest that the PS-Tyro3 and -MerTK axis mediates important signaling pathways to promote lung cancer progression. Genetic inhibition of endogenous PS may serve as a promising target for anticancer drug development." @default.
• W3214908802 created "2021-12-06" @default.
• W3214908802 creator A5029495254 @default.
• W3214908802 creator A5048871839 @default.
• W3214908802 creator A5076466324 @default.
• W3214908802 creator A5083032034 @default.
• W3214908802 date "2021-12-01" @default.
• W3214908802 modified "2023-09-26" @default.
• W3214908802 title "Protein S-mediated signal transduction pathway regulates lung cancer cell proliferation, migration and angiogenesis" @default.
• W3214908802 cites W1510051502 @default.
• W3214908802 cites W1541260647 @default.
• W3214908802 cites W1607701774 @default.
• W3214908802 cites W1645383690 @default.
• W3214908802 cites W1893558841 @default.
• W3214908802 cites W1973362842 @default.
• W3214908802 cites W1981294952 @default.
• W3214908802 cites W1985379136 @default.
• W3214908802 cites W1985385147 @default.
• W3214908802 cites W1992977955 @default.
• W3214908802 cites W2003166231 @default.
• W3214908802 cites W2022480285 @default.
• W3214908802 cites W2028449558 @default.
• W3214908802 cites W2032275395 @default.
• W3214908802 cites W2040196938 @default.
• W3214908802 cites W2060075404 @default.
• W3214908802 cites W2066113694 @default.
• W3214908802 cites W2084472730 @default.
• W3214908802 cites W2132169351 @default.
• W3214908802 cites W2138735856 @default.
• W3214908802 cites W2145950952 @default.
• W3214908802 cites W2153326117 @default.
• W3214908802 cites W2156713309 @default.
• W3214908802 cites W2168691181 @default.
• W3214908802 cites W2296139876 @default.
• W3214908802 cites W2344146347 @default.
• W3214908802 cites W2474423791 @default.
• W3214908802 cites W2546851576 @default.
• W3214908802 cites W2557661526 @default.
• W3214908802 cites W2738036354 @default.
• W3214908802 cites W2742440932 @default.
• W3214908802 cites W2756333660 @default.
• W3214908802 cites W2777675152 @default.
• W3214908802 cites W2792245912 @default.
• W3214908802 cites W2801517459 @default.
• W3214908802 cites W2901882455 @default.
• W3214908802 cites W2903179655 @default.
• W3214908802 cites W2959497269 @default.
• W3214908802 cites W2982513364 @default.
• W3214908802 cites W2991242835 @default.
• W3214908802 cites W2991514948 @default.
• W3214908802 cites W2994642443 @default.
• W3214908802 cites W3093590736 @default.
• W3214908802 cites W4250512610 @default.
• W3214908802 cites W4250570549 @default.
• W3214908802 cites W67061917 @default.
• W3214908802 doi "https://doi.org/10.1016/j.hemonc.2021.11.002" @default.
• W3214908802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34906536" @default.
• W3214908802 hasPublicationYear "2021" @default.
• W3214908802 type Work @default.
• W3214908802 sameAs 3214908802 @default.
• W3214908802 citedByCount "2" @default.
• W3214908802 countsByYear W32149088022022 @default.
• W3214908802 countsByYear W32149088022023 @default.
• W3214908802 crossrefType "journal-article" @default.
• W3214908802 hasAuthorship W3214908802A5029495254 @default.
• W3214908802 hasAuthorship W3214908802A5048871839 @default.
• W3214908802 hasAuthorship W3214908802A5076466324 @default.
• W3214908802 hasAuthorship W3214908802A5083032034 @default.
• W3214908802 hasBestOaLocation W32149088021 @default.
• W3214908802 hasConcept C101544691 @default.
• W3214908802 hasConcept C121608353 @default.
• W3214908802 hasConcept C128240485 @default.
• W3214908802 hasConcept C170493617 @default.
• W3214908802 hasConcept C189165786 @default.
• W3214908802 hasConcept C2775893135 @default.
• W3214908802 hasConcept C2779256057 @default.
• W3214908802 hasConcept C2780394083 @default.
• W3214908802 hasConcept C2781185341 @default.
• W3214908802 hasConcept C502942594 @default.
• W3214908802 hasConcept C54355233 @default.
• W3214908802 hasConcept C55493867 @default.
• W3214908802 hasConcept C62112901 @default.
• W3214908802 hasConcept C62478195 @default.
• W3214908802 hasConcept C75217442 @default.
• W3214908802 hasConcept C86803240 @default.
• W3214908802 hasConcept C95444343 @default.
• W3214908802 hasConceptScore W3214908802C101544691 @default.
• W3214908802 hasConceptScore W3214908802C121608353 @default.
• W3214908802 hasConceptScore W3214908802C128240485 @default.
• W3214908802 hasConceptScore W3214908802C170493617 @default.
• W3214908802 hasConceptScore W3214908802C189165786 @default.
• W3214908802 hasConceptScore W3214908802C2775893135 @default.
• W3214908802 hasConceptScore W3214908802C2779256057 @default.
• W3214908802 hasConceptScore W3214908802C2780394083 @default.
• W3214908802 hasConceptScore W3214908802C2781185341 @default.
• W3214908802 hasConceptScore W3214908802C502942594 @default.
• W3214908802 hasConceptScore W3214908802C54355233 @default.
• W3214908802 hasConceptScore W3214908802C55493867 @default.
• W3214908802 hasConceptScore W3214908802C62112901 @default.
• W3214908802 hasConceptScore W3214908802C62478195 @default.

• next