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• W3214915532 endingPage "12034" @default.
• W3214915532 startingPage "12017" @default.
• W3214915532 abstract "A 1969 report that described biochemical and activity properties of the three eukaryotic RNA polymerases revealed Pol III as highly distinguishable, even before its transcripts were identified. Now known to be the most complex, Pol III contains several stably-associated subunits referred to as built-in transcription factors (BITFs) that enable highly efficient RNA synthesis by a unique termination-associated recycling process. In vertebrates, subunit RPC7(α/β) can be of two forms, encoded by POLR3G or POLR3GL, with differential activity. Here we review promoter-dependent transcription by Pol III as an evolutionary perspective of eukaryotic tRNA expression. Pol III also provides nonconventional functions reportedly by promoter-independent transcription, one of which is RNA synthesis from DNA 3'-ends during repair. Another is synthesis of 5'ppp-RNA signaling molecules from cytoplasmic viral DNA in a pathway of interferon activation that is dysfunctional in immunocompromised patients with mutations in Pol III subunits. These unconventional functions are also reviewed, including evidence that link them to the BITF subunits. We also review data on a fraction of the human Pol III transcriptome that evolved to include vault RNAs and snaRs with activities related to differentiation, and in innate immune and tumor surveillance. The Pol III of higher eukaryotes does considerably more than housekeeping." @default.
• W3214915532 created "2021-12-06" @default.
• W3214915532 creator A5049076723 @default.
• W3214915532 creator A5079415508 @default.
• W3214915532 date "2021-11-26" @default.
• W3214915532 modified "2023-10-16" @default.
• W3214915532 title "The nuclear and cytoplasmic activities of RNA polymerase III, and an evolving transcriptome for surveillance" @default.
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