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- W3214946162 abstract "<b>Rationale:</b> Pulmonary hypertension (PH) is usually diagnosed quite late, but vascular modifications have early onset in smokers and COPD patients. Here we aim to provide size-based morphometric quantification of pulmonary arterial changes in smokers, mild-moderate COPD compared to healthy non-smokers. <b>Methods:</b> Movat’s Pentachrome staining was carried out for lung resections from normal lung function smokers (NLFS, n=6), small airway disease, (SAD, n=9), COPD current (COPD-CS, n=9), and ex-smokers (COPD-ES, n=10) and healthy non-smoker control (NC, n=12). Arteries measuring 100-1000 micron were blindly analyzed for total number of arteries per parenchymal tissue density and arterial wall thickness using advanced imaging software Image ProPlus V7.0. <b>Results:</b> We found a significant increment in total parenchymal tissue density (p value<0.01) and decline in total arterial numbers across all arterial size ranges in pathological groups compared to NC (p<0.001). In small to medium arteries (100-400microns) the wall thickness in pathological groups was significantly thicker than NC(p<0.01). This increase in arterial thickness across (100-400microns) in COPD-CS group specifically affected FEV1/FVC (%), (Spearman r’= -0.87, -0.74, -0.77, & p=0.004,0.028,0.030 respectively). Interestingly, a reversible trend was noticed in arterial thickness in COPD-ES, significantly lesser to COPD-CS in ranges between100-300microns (p<0.05). <b>Conclusion:</b> Smoking contributed to both reduced numbers and increased thickness across all arterial sizes most evidently in COPD-CS, that reversed with smoking cessation." @default.
- W3214946162 created "2021-12-06" @default.
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- W3214946162 date "2021-09-05" @default.
- W3214946162 modified "2023-10-16" @default.
- W3214946162 title "Increased arterial remodelling in smokers and mild-moderate COPD patients are indicative of potential early onset of pulmonary hypertension" @default.
- W3214946162 doi "https://doi.org/10.1183/13993003.congress-2021.oa1216" @default.
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