Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214974865> ?p ?o ?g. }
- W3214974865 endingPage "361" @default.
- W3214974865 startingPage "324" @default.
- W3214974865 abstract "Schizophrenia is associated with substantial unmet needs, highlighting the necessity for new treatments. This narrative review compares the pharmacology, clinical trial data and tolerability of novel medications to representative antipsychotics. Cariprazine, brexpiprazole and brilaroxazine are partial dopamine agonists effective in acute relapse. Lumateperone (serotonin and dopamine receptor antagonist) additionally benefits asocial and depressive symptoms. F17464 (D3 antagonist and 5-HT1A partial agonist) has one positive phase II study. Lu AF35700 (dopamine and serotonin receptor antagonist) was tested in treatment-resistance with no positive results. Pimavanserin, roluperidone, ulotaront and xanomeline do not act directly on the D2 receptor at clinical doses. Initial studies indicate pimavanserin and roluperidone improve negative symptoms. Ulotaront and xanomeline showed efficacy for positive and negative symptoms of schizophrenia in phase II trials. BI 409306, BI 425809 and MK-8189 target glutamatergic dysfunction in schizophrenia, though of these only BI 425809 showed efficacy. These medications largely have favourable cardiometabolic side-effect profiles. Overall, the novel pharmacology, clinical trial and tolerability data indicate these compounds are promising new additions to the therapeutic arsenal." @default.
- W3214974865 created "2021-12-06" @default.
- W3214974865 creator A5001601365 @default.
- W3214974865 creator A5008873444 @default.
- W3214974865 creator A5026331321 @default.
- W3214974865 creator A5051191207 @default.
- W3214974865 date "2022-01-01" @default.
- W3214974865 modified "2023-10-17" @default.
- W3214974865 title "New and emerging treatments for schizophrenia: a narrative review of their pharmacology, efficacy and side effect profile relative to established antipsychotics" @default.
- W3214974865 cites W118899563 @default.
- W3214974865 cites W1275714076 @default.
- W3214974865 cites W1546116904 @default.
- W3214974865 cites W1693113754 @default.
- W3214974865 cites W1966640793 @default.
- W3214974865 cites W1967630951 @default.
- W3214974865 cites W1968565337 @default.
- W3214974865 cites W1969499682 @default.
- W3214974865 cites W1971179661 @default.
- W3214974865 cites W1972973143 @default.
- W3214974865 cites W1976520993 @default.
- W3214974865 cites W1986619545 @default.
- W3214974865 cites W1990121386 @default.
- W3214974865 cites W2005714328 @default.
- W3214974865 cites W2009832071 @default.
- W3214974865 cites W2013618220 @default.
- W3214974865 cites W2037063823 @default.
- W3214974865 cites W2048264021 @default.
- W3214974865 cites W2057652738 @default.
- W3214974865 cites W2066363059 @default.
- W3214974865 cites W2074146160 @default.
- W3214974865 cites W2074570091 @default.
- W3214974865 cites W2074863161 @default.
- W3214974865 cites W2077138902 @default.
- W3214974865 cites W2081792830 @default.
- W3214974865 cites W2089934994 @default.
- W3214974865 cites W2097950056 @default.
- W3214974865 cites W2107881620 @default.
- W3214974865 cites W2108373295 @default.
- W3214974865 cites W2120893202 @default.
- W3214974865 cites W2121313171 @default.
- W3214974865 cites W2124201657 @default.
- W3214974865 cites W2130392097 @default.
- W3214974865 cites W2142137999 @default.
- W3214974865 cites W2145015856 @default.
- W3214974865 cites W2146809691 @default.
- W3214974865 cites W2148277355 @default.
- W3214974865 cites W2149860378 @default.
- W3214974865 cites W2151839057 @default.
- W3214974865 cites W2154849243 @default.
- W3214974865 cites W2156601000 @default.
- W3214974865 cites W2161441546 @default.
- W3214974865 cites W2167223183 @default.
- W3214974865 cites W2167715051 @default.
- W3214974865 cites W2202381266 @default.
- W3214974865 cites W2249246431 @default.
- W3214974865 cites W2295051011 @default.
- W3214974865 cites W2320155748 @default.
- W3214974865 cites W2340048768 @default.
- W3214974865 cites W2345937195 @default.
- W3214974865 cites W2350140856 @default.
- W3214974865 cites W2412915724 @default.
- W3214974865 cites W2466076674 @default.
- W3214974865 cites W2482680139 @default.
- W3214974865 cites W2509180953 @default.
- W3214974865 cites W2512071866 @default.
- W3214974865 cites W2517254183 @default.
- W3214974865 cites W2527824850 @default.
- W3214974865 cites W2546788800 @default.
- W3214974865 cites W2547465790 @default.
- W3214974865 cites W2550203616 @default.
- W3214974865 cites W2579907512 @default.
- W3214974865 cites W2586571825 @default.
- W3214974865 cites W2587606972 @default.
- W3214974865 cites W2588859449 @default.
- W3214974865 cites W2590283400 @default.
- W3214974865 cites W2599496923 @default.
- W3214974865 cites W2603643132 @default.
- W3214974865 cites W2605982210 @default.
- W3214974865 cites W2617727871 @default.
- W3214974865 cites W2724473643 @default.
- W3214974865 cites W2727400130 @default.
- W3214974865 cites W2728909081 @default.
- W3214974865 cites W2738334819 @default.
- W3214974865 cites W2741423365 @default.
- W3214974865 cites W2745466963 @default.
- W3214974865 cites W2754685807 @default.
- W3214974865 cites W2760836006 @default.
- W3214974865 cites W2763707279 @default.
- W3214974865 cites W2767793215 @default.
- W3214974865 cites W2769201758 @default.
- W3214974865 cites W2773220495 @default.
- W3214974865 cites W2777013718 @default.
- W3214974865 cites W2786897135 @default.
- W3214974865 cites W2793218225 @default.
- W3214974865 cites W2793227676 @default.
- W3214974865 cites W2794467050 @default.
- W3214974865 cites W2794768733 @default.
- W3214974865 cites W2794871031 @default.