FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214979106> ?p ?o ?g. }

• W3214979106 abstract "Harmful alleles can be under balancing selection due to an interplay of artificial selection for the variant in heterozygotes and purifying selection against the variant in homozygotes. These pleiotropic variants can remain at moderate to high frequency expressing an advantage for favorable traits in heterozygotes, while harmful in homozygotes. The impact on the population and selection strength depends on the consequence of the variant both in heterozygotes and homozygotes. The deleterious phenotype expressed in homozygotes can range from early lethality to a slightly lower fitness in the population. In this review, we explore a range of causative variants under balancing selection including loss-of-function variation (i.e., frameshift, stop-gained variants) and regulatory variation (affecting gene expression). We report that harmful alleles often affect orthologous genes in different species, often influencing analogous traits. The recent discoveries are mainly driven by the increasing genomic and phenotypic resources in livestock populations. However, the low frequency and sometimes subtle effects in homozygotes prevent accurate mapping of such pleiotropic variants, which requires novel strategies to discover. After discovery, the selection strategy for deleterious variants under balancing selection is under debate, as variants can contribute to the heterosis effect in crossbred animals in various livestock species, compensating for the loss in purebred animals. Nevertheless, gene-assisted selection is a useful tool to decrease the frequency of the harmful allele in the population, if desired. Together, this review marks various deleterious variants under balancing selection and describing the functional consequences at the molecular, phenotypic, and population level, providing a resource for further study." @default.
• W3214979106 created "2021-12-06" @default.
• W3214979106 creator A5043169383 @default.
• W3214979106 creator A5078484189 @default.
• W3214979106 date "2021-12-03" @default.
• W3214979106 modified "2023-10-18" @default.
• W3214979106 title "Review: Balancing Selection for Deleterious Alleles in Livestock" @default.
• W3214979106 cites W1493570549 @default.
• W3214979106 cites W1553199600 @default.
• W3214979106 cites W1590271440 @default.
• W3214979106 cites W1606387712 @default.
• W3214979106 cites W1608087467 @default.
• W3214979106 cites W175229893 @default.
• W3214979106 cites W1872560553 @default.
• W3214979106 cites W1916463466 @default.
• W3214979106 cites W1976730817 @default.
• W3214979106 cites W1977542592 @default.
• W3214979106 cites W1986034861 @default.
• W3214979106 cites W1986378002 @default.
• W3214979106 cites W1990106629 @default.
• W3214979106 cites W1990352386 @default.
• W3214979106 cites W1991437442 @default.
• W3214979106 cites W1995342267 @default.
• W3214979106 cites W1999619905 @default.
• W3214979106 cites W2000280737 @default.
• W3214979106 cites W2016356001 @default.
• W3214979106 cites W2021468173 @default.
• W3214979106 cites W2024044184 @default.
• W3214979106 cites W2024163052 @default.
• W3214979106 cites W2028523909 @default.
• W3214979106 cites W2031141864 @default.
• W3214979106 cites W2033754587 @default.
• W3214979106 cites W2039435867 @default.
• W3214979106 cites W2046232289 @default.
• W3214979106 cites W2046932648 @default.
• W3214979106 cites W2047876898 @default.
• W3214979106 cites W2053476755 @default.
• W3214979106 cites W2053702480 @default.
• W3214979106 cites W2062018530 @default.
• W3214979106 cites W2064810483 @default.
• W3214979106 cites W2065035179 @default.
• W3214979106 cites W2083478509 @default.
• W3214979106 cites W2091496948 @default.
• W3214979106 cites W2106495164 @default.
• W3214979106 cites W2124730138 @default.
• W3214979106 cites W2126505896 @default.
• W3214979106 cites W2129012279 @default.
• W3214979106 cites W2129198409 @default.
• W3214979106 cites W2130121981 @default.
• W3214979106 cites W2135124067 @default.
• W3214979106 cites W2143950698 @default.
• W3214979106 cites W2145854465 @default.
• W3214979106 cites W2146903966 @default.
• W3214979106 cites W2150910996 @default.
• W3214979106 cites W2150950003 @default.
• W3214979106 cites W2153001298 @default.
• W3214979106 cites W2302583546 @default.
• W3214979106 cites W2330229776 @default.
• W3214979106 cites W2419496090 @default.
• W3214979106 cites W2496273744 @default.
• W3214979106 cites W2523032102 @default.
• W3214979106 cites W2566259295 @default.
• W3214979106 cites W2747685557 @default.
• W3214979106 cites W2771311143 @default.
• W3214979106 cites W2771952068 @default.
• W3214979106 cites W2784784123 @default.
• W3214979106 cites W2885943027 @default.
• W3214979106 cites W2887981236 @default.
• W3214979106 cites W2888306444 @default.
• W3214979106 cites W2889681800 @default.
• W3214979106 cites W2902798405 @default.
• W3214979106 cites W2921234090 @default.
• W3214979106 cites W2949832836 @default.
• W3214979106 cites W2953085153 @default.
• W3214979106 cites W2990644961 @default.
• W3214979106 cites W2995039599 @default.
• W3214979106 cites W2998948970 @default.
• W3214979106 cites W3006029413 @default.
• W3214979106 cites W3014369994 @default.
• W3214979106 cites W3097352870 @default.
• W3214979106 doi "https://doi.org/10.3389/fgene.2021.761728" @default.
• W3214979106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34925454" @default.
• W3214979106 hasPublicationYear "2021" @default.
• W3214979106 type Work @default.
• W3214979106 sameAs 3214979106 @default.
• W3214979106 citedByCount "4" @default.
• W3214979106 countsByYear W32149791062022 @default.
• W3214979106 countsByYear W32149791062023 @default.
• W3214979106 crossrefType "journal-article" @default.
• W3214979106 hasAuthorship W3214979106A5043169383 @default.
• W3214979106 hasAuthorship W3214979106A5078484189 @default.
• W3214979106 hasBestOaLocation W32149791063 @default.
• W3214979106 hasConcept C104317684 @default.
• W3214979106 hasConcept C127716648 @default.
• W3214979106 hasConcept C137848329 @default.
• W3214979106 hasConcept C141231307 @default.
• W3214979106 hasConcept C144024400 @default.
• W3214979106 hasConcept C149923435 @default.
• W3214979106 hasConcept C153471976 @default.
• W3214979106 hasConcept C154945302 @default.

• next