FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214988717> ?p ?o ?g. }

• W3214988717 endingPage "121286" @default.
• W3214988717 startingPage "121286" @default.
• W3214988717 abstract "A functional multi-scale vascular network can promote 3D engineered tissue growth and improve transplantation outcome. In this work, by using a combination of living cells, biological hydrogel, and biodegradable synthetic polymer we fabricated a biocompatible, multi-scale vascular network (MSVT) within thick, implantable engineered tissues. Using a templating technique, macro-vessels were patterned in a 3D biodegradable polymeric scaffold seeded with endothelial and support cells within a collagen gel. The lumen of the macro-vessel was lined with endothelial cells, which further sprouted and anastomosed with the surrounding self-assembled capillaries. Anastomoses between the two-scaled vascular systems displayed tightly bonded cell junctions, as indicated by vascular endothelial cadherin expression. Moreover, MSVT functionality and patency were demonstrated by dextran passage through the interconnected multi-scale vasculature. Additionally, physiological flow conditions were applied with home-designed flow bioreactors, to achieve a MSVT with a natural endothelium structure. Finally, implantation of a multi-scale-vascularized graft in a mouse model resulted in extensive host vessel penetration into the graft and a significant increase in blood perfusion via the engineered vessels compared to control micro-scale-vascularized graft. Designing and fabricating such multi-scale vascular architectures within 3D engineered tissues may benefit both in vitro models and therapeutic translation research." @default.
• W3214988717 created "2021-12-06" @default.
• W3214988717 creator A5001080389 @default.
• W3214988717 creator A5012769290 @default.
• W3214988717 creator A5016977035 @default.
• W3214988717 creator A5024381751 @default.
• W3214988717 creator A5076417738 @default.
• W3214988717 creator A5085655241 @default.
• W3214988717 date "2022-01-01" @default.
• W3214988717 modified "2023-10-18" @default.
• W3214988717 title "Integrating engineered macro vessels with self-assembled capillaries in 3D implantable tissue for promoting vascular integration in-vivo" @default.
• W3214988717 cites W1919370033 @default.
• W3214988717 cites W1981030985 @default.
• W3214988717 cites W1998510840 @default.
• W3214988717 cites W2017852297 @default.
• W3214988717 cites W2018842062 @default.
• W3214988717 cites W2020831247 @default.
• W3214988717 cites W2029610231 @default.
• W3214988717 cites W2045852090 @default.
• W3214988717 cites W2050384796 @default.
• W3214988717 cites W2050935277 @default.
• W3214988717 cites W2060892505 @default.
• W3214988717 cites W2063665585 @default.
• W3214988717 cites W2066390373 @default.
• W3214988717 cites W2071760903 @default.
• W3214988717 cites W2083583322 @default.
• W3214988717 cites W2084026893 @default.
• W3214988717 cites W2086452068 @default.
• W3214988717 cites W2099361891 @default.
• W3214988717 cites W2102075858 @default.
• W3214988717 cites W2112282929 @default.
• W3214988717 cites W2122612027 @default.
• W3214988717 cites W2141126811 @default.
• W3214988717 cites W2154837723 @default.
• W3214988717 cites W2178291686 @default.
• W3214988717 cites W2191317602 @default.
• W3214988717 cites W2293269085 @default.
• W3214988717 cites W2293502352 @default.
• W3214988717 cites W2295454854 @default.
• W3214988717 cites W2585886282 @default.
• W3214988717 cites W2594202991 @default.
• W3214988717 cites W2615584725 @default.
• W3214988717 cites W2715720471 @default.
• W3214988717 cites W2889308220 @default.
• W3214988717 cites W2912145890 @default.
• W3214988717 cites W2913395051 @default.
• W3214988717 cites W2914264497 @default.
• W3214988717 cites W2919083791 @default.
• W3214988717 cites W2937820813 @default.
• W3214988717 cites W2966654380 @default.
• W3214988717 cites W2971539042 @default.
• W3214988717 cites W3000187965 @default.
• W3214988717 cites W3037331335 @default.
• W3214988717 cites W3086574461 @default.
• W3214988717 doi "https://doi.org/10.1016/j.biomaterials.2021.121286" @default.
• W3214988717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34871879" @default.
• W3214988717 hasPublicationYear "2022" @default.
• W3214988717 type Work @default.
• W3214988717 sameAs 3214988717 @default.
• W3214988717 citedByCount "25" @default.
• W3214988717 countsByYear W32149887172021 @default.
• W3214988717 countsByYear W32149887172022 @default.
• W3214988717 countsByYear W32149887172023 @default.
• W3214988717 crossrefType "journal-article" @default.
• W3214988717 hasAuthorship W3214988717A5001080389 @default.
• W3214988717 hasAuthorship W3214988717A5012769290 @default.
• W3214988717 hasAuthorship W3214988717A5016977035 @default.
• W3214988717 hasAuthorship W3214988717A5024381751 @default.
• W3214988717 hasAuthorship W3214988717A5076417738 @default.
• W3214988717 hasAuthorship W3214988717A5085655241 @default.
• W3214988717 hasBestOaLocation W32149887171 @default.
• W3214988717 hasConcept C118552586 @default.
• W3214988717 hasConcept C131631996 @default.
• W3214988717 hasConcept C134018914 @default.
• W3214988717 hasConcept C136229726 @default.
• W3214988717 hasConcept C141071460 @default.
• W3214988717 hasConcept C150903083 @default.
• W3214988717 hasConcept C171250308 @default.
• W3214988717 hasConcept C192562407 @default.
• W3214988717 hasConcept C207001950 @default.
• W3214988717 hasConcept C2776992346 @default.
• W3214988717 hasConcept C2777663904 @default.
• W3214988717 hasConcept C2911091166 @default.
• W3214988717 hasConcept C49892992 @default.
• W3214988717 hasConcept C71924100 @default.
• W3214988717 hasConcept C86803240 @default.
• W3214988717 hasConcept C89429830 @default.
• W3214988717 hasConcept C95444343 @default.
• W3214988717 hasConceptScore W3214988717C118552586 @default.
• W3214988717 hasConceptScore W3214988717C131631996 @default.
• W3214988717 hasConceptScore W3214988717C134018914 @default.
• W3214988717 hasConceptScore W3214988717C136229726 @default.
• W3214988717 hasConceptScore W3214988717C141071460 @default.
• W3214988717 hasConceptScore W3214988717C150903083 @default.
• W3214988717 hasConceptScore W3214988717C171250308 @default.
• W3214988717 hasConceptScore W3214988717C192562407 @default.
• W3214988717 hasConceptScore W3214988717C207001950 @default.
• W3214988717 hasConceptScore W3214988717C2776992346 @default.

• next