Matches in SemOpenAlex for { <https://semopenalex.org/work/W3214996906> ?p ?o ?g. }
- W3214996906 endingPage "2380" @default.
- W3214996906 startingPage "2380" @default.
- W3214996906 abstract "Epstein-Barr virus (EBV) is the first reported oncogenic virus and infects more than 90% of adults worldwide. EBV can establish a latent infection in B lymphocytes which is essential for persistence and transmission. Glycoprotein gp42 is an indispensable member of the triggering complex for EBV entry into a B cell. The N-terminal region of gp42 plays a key role in binding to gH/gL and triggering subsequent membrane fusion. However, no antibody has been reported to recognize this region and the immunogenicity of gp42 N-domain remains unknown. In the present study, we have generated a panel of nine mAbs against the gp42 N-terminal region (six mAbs to gp42-44-61aa and three mAbs to gp42-67-81aa). These mAbs show excellent binding activity and recognize different key residues locating on the gp42 N-domain. Among the nine mAbs, 4H7, 4H8 and 11G10 cross-react with rhLCV-gp42 while other mAbs specifically recognize EBV-gp42. Our newly obtained mAbs provide a useful tool for investigating the gp42 function and viral infection mechanism of γ-Herpesvirus. Furthermore, we assess the immunogenicity of the gp42 N-terminal region using the HBc149 particle as a carrier protein. The chimeric VLPs can induce high antibody titers and elicit neutralizing humoral responses to block EBV infection. More rational and effective designs are required to promote the gp42-N terminal region to become an epitope-based vaccine." @default.
- W3214996906 created "2021-12-06" @default.
- W3214996906 creator A5001355070 @default.
- W3214996906 creator A5002318539 @default.
- W3214996906 creator A5006044796 @default.
- W3214996906 creator A5013163508 @default.
- W3214996906 creator A5027193426 @default.
- W3214996906 creator A5035035593 @default.
- W3214996906 creator A5047318884 @default.
- W3214996906 creator A5047327093 @default.
- W3214996906 creator A5060049022 @default.
- W3214996906 creator A5078732636 @default.
- W3214996906 creator A5081621577 @default.
- W3214996906 date "2021-11-28" @default.
- W3214996906 modified "2023-10-16" @default.
- W3214996906 title "Antibody Generation and Immunogenicity Analysis of EBV gp42 N-Terminal Region" @default.
- W3214996906 cites W1505803398 @default.
- W3214996906 cites W1534082012 @default.
- W3214996906 cites W1974105917 @default.
- W3214996906 cites W1974762536 @default.
- W3214996906 cites W1975888651 @default.
- W3214996906 cites W1977759154 @default.
- W3214996906 cites W1986406970 @default.
- W3214996906 cites W2002561725 @default.
- W3214996906 cites W2002683433 @default.
- W3214996906 cites W2012136514 @default.
- W3214996906 cites W2024864645 @default.
- W3214996906 cites W2028478629 @default.
- W3214996906 cites W2046714789 @default.
- W3214996906 cites W2048172399 @default.
- W3214996906 cites W2050680529 @default.
- W3214996906 cites W2055861239 @default.
- W3214996906 cites W2060629036 @default.
- W3214996906 cites W2068046625 @default.
- W3214996906 cites W2068289773 @default.
- W3214996906 cites W2070907961 @default.
- W3214996906 cites W2075843947 @default.
- W3214996906 cites W2095572685 @default.
- W3214996906 cites W2096651356 @default.
- W3214996906 cites W2102085418 @default.
- W3214996906 cites W2107638886 @default.
- W3214996906 cites W2109482094 @default.
- W3214996906 cites W2123119659 @default.
- W3214996906 cites W2128320744 @default.
- W3214996906 cites W2136724377 @default.
- W3214996906 cites W2138822872 @default.
- W3214996906 cites W2139340788 @default.
- W3214996906 cites W2156380357 @default.
- W3214996906 cites W2162924471 @default.
- W3214996906 cites W2163905089 @default.
- W3214996906 cites W2169697968 @default.
- W3214996906 cites W2203440295 @default.
- W3214996906 cites W2208653744 @default.
- W3214996906 cites W2270256774 @default.
- W3214996906 cites W2407498715 @default.
- W3214996906 cites W2526219494 @default.
- W3214996906 cites W2615361789 @default.
- W3214996906 cites W2747929863 @default.
- W3214996906 cites W2767363048 @default.
- W3214996906 cites W2802763804 @default.
- W3214996906 cites W2903224651 @default.
- W3214996906 cites W3023304731 @default.
- W3214996906 cites W3036816875 @default.
- W3214996906 cites W3093517553 @default.
- W3214996906 doi "https://doi.org/10.3390/v13122380" @default.
- W3214996906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34960650" @default.
- W3214996906 hasPublicationYear "2021" @default.
- W3214996906 type Work @default.
- W3214996906 sameAs 3214996906 @default.
- W3214996906 citedByCount "6" @default.
- W3214996906 countsByYear W32149969062022 @default.
- W3214996906 countsByYear W32149969062023 @default.
- W3214996906 crossrefType "journal-article" @default.
- W3214996906 hasAuthorship W3214996906A5001355070 @default.
- W3214996906 hasAuthorship W3214996906A5002318539 @default.
- W3214996906 hasAuthorship W3214996906A5006044796 @default.
- W3214996906 hasAuthorship W3214996906A5013163508 @default.
- W3214996906 hasAuthorship W3214996906A5027193426 @default.
- W3214996906 hasAuthorship W3214996906A5035035593 @default.
- W3214996906 hasAuthorship W3214996906A5047318884 @default.
- W3214996906 hasAuthorship W3214996906A5047327093 @default.
- W3214996906 hasAuthorship W3214996906A5060049022 @default.
- W3214996906 hasAuthorship W3214996906A5078732636 @default.
- W3214996906 hasAuthorship W3214996906A5081621577 @default.
- W3214996906 hasBestOaLocation W32149969061 @default.
- W3214996906 hasConcept C159047783 @default.
- W3214996906 hasConcept C159654299 @default.
- W3214996906 hasConcept C195616568 @default.
- W3214996906 hasConcept C203014093 @default.
- W3214996906 hasConcept C2780868878 @default.
- W3214996906 hasConcept C86803240 @default.
- W3214996906 hasConceptScore W3214996906C159047783 @default.
- W3214996906 hasConceptScore W3214996906C159654299 @default.
- W3214996906 hasConceptScore W3214996906C195616568 @default.
- W3214996906 hasConceptScore W3214996906C203014093 @default.
- W3214996906 hasConceptScore W3214996906C2780868878 @default.
- W3214996906 hasConceptScore W3214996906C86803240 @default.
- W3214996906 hasFunder F4320321001 @default.