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- W3215015730 abstract "Some DNA viruses, such as BKPyV, are capable of inducing neoplastic transformation in human tissues through still unclear mechanisms. The goal of this study is to investigate the carcinogenic potential of BK polyomavirus (BKPyV) in human embryonic kidney 293 (Hek293) cells, dissecting the molecular mechanism that determines the neoplastic transformation.BKPyV, isolated from urine samples of infected patients, was used to infect monolayers of Hek293 cells. Subsequently, intracellular redox changes, GSH/GSSH concentration by HPLC, and reactive oxygen/nitrogen species (ROS/RNS) production were monitored. Moreover, to understand the signaling pathway underlying the neoplastic transformation, the redox-sensitive HFS1-Hsp27 molecular axis was examined using the flavonoid quercetin and polishort hairpin RNA technologies.The data obtained show that while BKPyV replication is closely linked to the transcription factor p53, the increase in Hek293 cell proliferation is due to the activation of the signaling pathway mediated by HSF1-Hsp27. In fact, its inhibition blocks viral replication and cell growth, respectively.The HSF1-Hsp27 signaling pathway is involved in BKPyV infection and cellular replication and its activation, which could be involved in cell transformation." @default.
- W3215015730 created "2021-12-06" @default.
- W3215015730 creator A5007336855 @default.
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- W3215015730 creator A5081862979 @default.
- W3215015730 date "2021-11-20" @default.
- W3215015730 modified "2023-09-23" @default.
- W3215015730 title "BK Polyomavirus Activates HSF1 Stimulating Human Kidney Hek293 Cell Proliferation" @default.
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- W3215015730 doi "https://doi.org/10.1155/2021/9176993" @default.
- W3215015730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8627348" @default.
- W3215015730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34845419" @default.
- W3215015730 hasPublicationYear "2021" @default.
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