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- W3215020105 abstract "<b>Introduction:</b> Over the past decades, in-hospital mortality of HIV patients has dropped significantly. However, these patients remain at high risk for critical illness due to severe opportunistic infections with pulmonary complications and therefore require treatment on ICU. <b>Objectives:</b> To study and evaluate for prognostic factors and overall survival in HIV-positive patients treated on non-operative ICU. <b>Methods:</b> We analyzed 62 patients undergoing ICU treatment due to infectious and life-threatening complications between 2009 and 2019. <b>Results:</b> n=54 patients required ventilatory support during first 24 hours with either nasal cannula/ mask (n=12), or non-invasive ventilation (n=16) or invasive ventilation (IV, n=26)). SAPS-II (p=.003) and APACHE-II (p=.038) prognosis scores were validated for 30-day survival in our cohort. Via AUC-ROC cut-off [c/o] values for p<sub>MAX</sub> (c/o 16.5 cmH<sub>2</sub>O, p=.036), PEEP (c/o 7.5 cmH<sub>2</sub>O, p=.037), pH (c/o 7.31, p=.001), platelet count (c/o 164.000 /µl, p=.002) and ventilation mode (IV vs other, p=.041) were identified to be significant univariate 30-day survival parameters. However, CD4- and white blood cell- count did not alter outcome. Platelet count (HR 4.5 for < 164.000 /µl, p=.023) and pH (HR 4.9 for < 7.31, p=.015) remained independent survival parameters in multivariate Cox regression. Overall survival at day 30 was 77.4 %. <b>Conclusion:</b> SAPS-II and APACHE-II can be used to evaluate for HIV patients’ outcome on non-operative ICU. Univariately, ventilation parameters influenced outcome of HIV-patients on ICU. However, in multivariate analysis, pH and platelet count relevantly predicted short term survival." @default.
- W3215020105 created "2021-12-06" @default.
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- W3215020105 date "2021-09-05" @default.
- W3215020105 modified "2023-09-23" @default.
- W3215020105 title "Risk factors and prognostic impact of ventilatory support in HIV patients on Intensive Care Unit (ICU)" @default.
- W3215020105 doi "https://doi.org/10.1183/13993003.congress-2021.pa898" @default.
- W3215020105 hasPublicationYear "2021" @default.
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