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• W3215020730 abstract "Alzheimer's and Parkinson's diseases (AD and PD) are amongst top of the prevalent neurodegenerative disease. One-third of PD patients are diagnosed with dementia, a pre-symptom of AD, but the underlying mechanism is elusive. Amyloid beta (Aβ) and α-synuclein are two of the most investigated proteins, whose pathological aggregation and spreading are crucial to the pathogenesis of AD and PD, respectively. Transcriptomic studies of the mammalian central nervous system shed light on gene expression profiles at molecular levels, regarding the complexity of neuronal morphologies and electrophysiological inputs/outputs. In the last decade, the booming of the single-cell RNA sequencing technique helped to understand gene expression patterns, alternative splicing, novel transcripts, and signal pathways in the nervous system at single-cell levels, providing insight for molecular taxonomy and mechanistic targets of the degenerative nervous system. Here, we re-visited the cell-cell transmission mechanisms of Aβ and α-synuclein in mediating disease propagation, and summarized recent single-cell transcriptome sequencing from different perspectives and discussed its understanding of neurodegenerative diseases." @default.
• W3215020730 created "2021-12-06" @default.
• W3215020730 creator A5024906658 @default.
• W3215020730 creator A5055555472 @default.
• W3215020730 creator A5091127487 @default.
• W3215020730 date "2021-11-18" @default.
• W3215020730 modified "2023-10-16" @default.
• W3215020730 title "Revisit the Cellular Transmission and Emerging Techniques in Understanding the Mechanisms of Proteinopathies" @default.
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• W3215020730 doi "https://doi.org/10.3389/fnins.2021.781722" @default.
• W3215020730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34867177" @default.
• W3215020730 hasPublicationYear "2021" @default.
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