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- W3215024654 abstract "The properties of acid deoxyribonuclease purified from human placenta have been investigated, and serial estimation of acid and alkaline deoxyribonuclease in human placenta has been performed. The acid deoxyribonuclease is partially purified forty-fold with specific activity of 240 units/㎎ protein. The acid deoxyribonuclease having an optimal pH around 5 is heat-labile with complete loss of activity at 70 for 10 minutes. The acid deoxyribonuclease is inhibited by Mg^(2+), Mn^(2+), Car and Co^(2+) above 1 mM concentration, suggesting that the enzyme is not dependent on divalent cations. The acid deoxyribonuclease acts on both native and heat-denatured DNA with preference for the former. A gradual decrease in the acid deoxyribonuclease activity occurs with advancing gestation after 20 weeks, the activity at term being about one-fourth of that before 20 weeks. The alkaline deoxyribonuclease activity is maintained untill approximately the 16th week of gestation at which the functioning villi has been established, and thereafter decreases rapidly with no apparent activity about 28 weeks. From the activity changes with gestational age, it is discussed that the acid deoxyribonuclease is related to DNA synthesis of the placenta whereas the alkaline deoxyribonuclease plays an important role in the formation of the functioning villi, suggesting that alkaline deoxyribonuclease is a useful enzyme to evaluate the function of the early placenta." @default.
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- W3215024654 date "1976-01-01" @default.
- W3215024654 modified "2023-09-24" @default.
- W3215024654 title "원저 ; 태반조직의 Nucleases 에 관한 연구 ( 1 ) 사람 태반조직의 Deoxyribonucleases" @default.
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