Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215036364> ?p ?o ?g. }
- W3215036364 abstract "Cancer cells acquire genetic heterogeneity to escape from immune surveillance during tumor evolution, but a systematic approach to distinguish driver from passenger mutations is lacking. Here we investigate the impact of different immune pressure on tumor clonal dynamics and immune evasion mechanism, by combining massive parallel sequencing of immune edited tumors and CRISPR library screens in syngeneic mouse tumor model and co-culture system. We find that the core microRNA (miRNA) biogenesis and targeting machinery maintains the sensitivity of cancer cells to PD-1-independent T cell-mediated cytotoxicity. Genetic inactivation of the machinery or re-introduction of ANKRD52 frequent patient mutations dampens the JAK-STAT-interferon-γ signaling and antigen presentation in cancer cells, largely by abolishing miR-155-targeted silencing of suppressor of cytokine signaling 1 (SOCS1). Expression of each miRNA machinery component strongly correlates with intratumoral T cell infiltration in nearly all human cancer types. Our data indicate that the evolutionarily conserved miRNA pathway can be exploited by cancer cells to escape from T cell-mediated elimination and immunotherapy." @default.
- W3215036364 created "2021-12-06" @default.
- W3215036364 creator A5006125769 @default.
- W3215036364 creator A5009966547 @default.
- W3215036364 creator A5012049169 @default.
- W3215036364 creator A5023363049 @default.
- W3215036364 creator A5031447675 @default.
- W3215036364 creator A5036144965 @default.
- W3215036364 creator A5038055814 @default.
- W3215036364 creator A5039070819 @default.
- W3215036364 creator A5042227692 @default.
- W3215036364 creator A5044619252 @default.
- W3215036364 creator A5048880663 @default.
- W3215036364 creator A5051056359 @default.
- W3215036364 creator A5067887136 @default.
- W3215036364 creator A5078915396 @default.
- W3215036364 creator A5081275530 @default.
- W3215036364 creator A5083033253 @default.
- W3215036364 date "2021-12-01" @default.
- W3215036364 modified "2023-10-06" @default.
- W3215036364 title "Tumor evolution selectively inactivates the core microRNA machinery for immune evasion" @default.
- W3215036364 cites W1527383154 @default.
- W3215036364 cites W1934094702 @default.
- W3215036364 cites W1955732360 @default.
- W3215036364 cites W1984068087 @default.
- W3215036364 cites W1989395650 @default.
- W3215036364 cites W2000496185 @default.
- W3215036364 cites W2040164466 @default.
- W3215036364 cites W2046368638 @default.
- W3215036364 cites W2052101095 @default.
- W3215036364 cites W2063375027 @default.
- W3215036364 cites W2063771876 @default.
- W3215036364 cites W2077330022 @default.
- W3215036364 cites W2085441977 @default.
- W3215036364 cites W2093248369 @default.
- W3215036364 cites W2105549148 @default.
- W3215036364 cites W2107429737 @default.
- W3215036364 cites W2119180969 @default.
- W3215036364 cites W2122205306 @default.
- W3215036364 cites W2127749855 @default.
- W3215036364 cites W2130116522 @default.
- W3215036364 cites W2130183546 @default.
- W3215036364 cites W2130410032 @default.
- W3215036364 cites W2134471382 @default.
- W3215036364 cites W2138255346 @default.
- W3215036364 cites W2149848115 @default.
- W3215036364 cites W2150752820 @default.
- W3215036364 cites W2162674813 @default.
- W3215036364 cites W2169456326 @default.
- W3215036364 cites W2214074259 @default.
- W3215036364 cites W2299181842 @default.
- W3215036364 cites W2436603111 @default.
- W3215036364 cites W2465860350 @default.
- W3215036364 cites W2557336488 @default.
- W3215036364 cites W2583057870 @default.
- W3215036364 cites W2587048937 @default.
- W3215036364 cites W2601742683 @default.
- W3215036364 cites W2601885162 @default.
- W3215036364 cites W2617316779 @default.
- W3215036364 cites W2736476343 @default.
- W3215036364 cites W2744743363 @default.
- W3215036364 cites W2761575992 @default.
- W3215036364 cites W2761586559 @default.
- W3215036364 cites W2765417948 @default.
- W3215036364 cites W2771952185 @default.
- W3215036364 cites W2782124401 @default.
- W3215036364 cites W2782183686 @default.
- W3215036364 cites W2796207838 @default.
- W3215036364 cites W2904139947 @default.
- W3215036364 cites W2906335862 @default.
- W3215036364 cites W2911986456 @default.
- W3215036364 cites W2914335731 @default.
- W3215036364 cites W2924359886 @default.
- W3215036364 cites W2944727022 @default.
- W3215036364 cites W2948371032 @default.
- W3215036364 cites W2950524924 @default.
- W3215036364 cites W2953757801 @default.
- W3215036364 cites W2956135855 @default.
- W3215036364 cites W2956987968 @default.
- W3215036364 cites W2964936150 @default.
- W3215036364 cites W2968188498 @default.
- W3215036364 cites W2990393399 @default.
- W3215036364 cites W2999754525 @default.
- W3215036364 cites W3000339487 @default.
- W3215036364 cites W3016635484 @default.
- W3215036364 cites W3027286012 @default.
- W3215036364 cites W3035764705 @default.
- W3215036364 cites W3039954766 @default.
- W3215036364 cites W3083613542 @default.
- W3215036364 cites W3088005314 @default.
- W3215036364 cites W3088246260 @default.
- W3215036364 cites W3092587231 @default.
- W3215036364 cites W3118867008 @default.
- W3215036364 cites W3176649308 @default.
- W3215036364 doi "https://doi.org/10.1038/s41467-021-27331-3" @default.
- W3215036364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34853298" @default.
- W3215036364 hasPublicationYear "2021" @default.
- W3215036364 type Work @default.
- W3215036364 sameAs 3215036364 @default.
- W3215036364 citedByCount "4" @default.