FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3215058732> ?p ?o ?g. }

• W3215058732 endingPage "2954" @default.
• W3215058732 startingPage "2954" @default.
• W3215058732 abstract "Foodborne Staphylococcus aureus (S. aureus) has attracted widespread attention due to its foodborne infection and food poisoning in human. Shikonin exhibits antibacterial activity against a variety of microorganisms, but there are few studies on its antibacterial activity against S. aureus. This study aims to explore the antibacterial activity and mechanism of shikonin against foodborne S. aureus. The results show that the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) of shikonin were equal for all tested strains ranging from 35 μg/mL to 70 μg/mL. Shikonin inhibited the growth of S. aureus by reducing intracellular ATP concentrations, hyperpolarizing cell membrane, destroying the integrity of cell membrane, and changing cell morphology. At the non-inhibitory concentrations (NICs), shikonin significantly inhibited biofilm formation of S. aureus, which was attributed to inhibiting the expression of cidA and sarA genes. Moreover, shikonin also markedly inhibited the transcription and expression of virulence genes (sea and hla) in S. aureus. In addition, shikonin has exhibited antibacterial ability against both planktonic and biofilm forms of S. aureus. Importantly, in vivo results show that shikonin has excellent biocompatibility. Moreover, both the heat stability of shikonin and the antimicrobial activity of shikonin against S. aureus were excellent in food. Our findings suggest that shikonin are promising for use as a natural food additive, and it also has great potential in effectively controlling the contamination of S. aureus in food and reducing the number of illnesses associated with S. aureus." @default.
• W3215058732 created "2021-12-06" @default.
• W3215058732 creator A5029003833 @default.
• W3215058732 creator A5031433631 @default.
• W3215058732 creator A5047405665 @default.
• W3215058732 creator A5053861388 @default.
• W3215058732 creator A5066863522 @default.
• W3215058732 creator A5074880791 @default.
• W3215058732 creator A5077328070 @default.
• W3215058732 creator A5085441351 @default.
• W3215058732 date "2021-12-01" @default.
• W3215058732 modified "2023-10-14" @default.
• W3215058732 title "Control of Foodborne Staphylococcus aureus by Shikonin, a Natural Extract" @default.
• W3215058732 cites W1530458177 @default.
• W3215058732 cites W1531268983 @default.
• W3215058732 cites W1967370316 @default.
• W3215058732 cites W1967599807 @default.
• W3215058732 cites W1983848182 @default.
• W3215058732 cites W1998935905 @default.
• W3215058732 cites W2006836695 @default.
• W3215058732 cites W2023662078 @default.
• W3215058732 cites W2026925161 @default.
• W3215058732 cites W2029615274 @default.
• W3215058732 cites W2042182233 @default.
• W3215058732 cites W2044206614 @default.
• W3215058732 cites W2063501589 @default.
• W3215058732 cites W2067086314 @default.
• W3215058732 cites W2069068014 @default.
• W3215058732 cites W2069510563 @default.
• W3215058732 cites W2073247044 @default.
• W3215058732 cites W2079526641 @default.
• W3215058732 cites W2095929279 @default.
• W3215058732 cites W2120593137 @default.
• W3215058732 cites W2121897239 @default.
• W3215058732 cites W2122836009 @default.
• W3215058732 cites W2129425742 @default.
• W3215058732 cites W2145486808 @default.
• W3215058732 cites W2156879228 @default.
• W3215058732 cites W2165016327 @default.
• W3215058732 cites W2173629901 @default.
• W3215058732 cites W2278390975 @default.
• W3215058732 cites W2300498794 @default.
• W3215058732 cites W2330881877 @default.
• W3215058732 cites W2514161057 @default.
• W3215058732 cites W2560523611 @default.
• W3215058732 cites W2569355020 @default.
• W3215058732 cites W2584780256 @default.
• W3215058732 cites W2591113798 @default.
• W3215058732 cites W2599446324 @default.
• W3215058732 cites W2601429695 @default.
• W3215058732 cites W2735498829 @default.
• W3215058732 cites W2749039870 @default.
• W3215058732 cites W2751297260 @default.
• W3215058732 cites W2881784221 @default.
• W3215058732 cites W2885765771 @default.
• W3215058732 cites W2886648346 @default.
• W3215058732 cites W2888638470 @default.
• W3215058732 cites W2895063310 @default.
• W3215058732 cites W2971201446 @default.
• W3215058732 cites W2974397402 @default.
• W3215058732 cites W2976791673 @default.
• W3215058732 cites W3005945442 @default.
• W3215058732 cites W3025113068 @default.
• W3215058732 cites W3038129845 @default.
• W3215058732 cites W3046976534 @default.
• W3215058732 cites W3049282645 @default.
• W3215058732 cites W3083669825 @default.
• W3215058732 cites W3165495857 @default.
• W3215058732 cites W4210959812 @default.
• W3215058732 doi "https://doi.org/10.3390/foods10122954" @default.
• W3215058732 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34945505" @default.
• W3215058732 hasPublicationYear "2021" @default.
• W3215058732 type Work @default.
• W3215058732 sameAs 3215058732 @default.
• W3215058732 citedByCount "9" @default.
• W3215058732 countsByYear W32150587322022 @default.
• W3215058732 countsByYear W32150587322023 @default.
• W3215058732 crossrefType "journal-article" @default.
• W3215058732 hasAuthorship W3215058732A5029003833 @default.
• W3215058732 hasAuthorship W3215058732A5031433631 @default.
• W3215058732 hasAuthorship W3215058732A5047405665 @default.
• W3215058732 hasAuthorship W3215058732A5053861388 @default.
• W3215058732 hasAuthorship W3215058732A5066863522 @default.
• W3215058732 hasAuthorship W3215058732A5074880791 @default.
• W3215058732 hasAuthorship W3215058732A5077328070 @default.
• W3215058732 hasAuthorship W3215058732A5085441351 @default.
• W3215058732 hasBestOaLocation W32150587321 @default.
• W3215058732 hasConcept C185592680 @default.
• W3215058732 hasConcept C2779489039 @default.
• W3215058732 hasConcept C2780104969 @default.
• W3215058732 hasConcept C31903555 @default.
• W3215058732 hasConcept C4937899 @default.
• W3215058732 hasConcept C523546767 @default.
• W3215058732 hasConcept C54355233 @default.
• W3215058732 hasConcept C58123911 @default.
• W3215058732 hasConcept C86803240 @default.
• W3215058732 hasConcept C89423630 @default.
• W3215058732 hasConceptScore W3215058732C185592680 @default.

• next