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- W3215083090 abstract "First cases that point at a correlation between SARS-CoV-2 infections and the development of Parkinson's disease (PD) have been reported. Currently, it is unclear if there is also a direct causal link between these diseases. To obtain first insights into a possible molecular relation between viral infections and the aggregation of α-synuclein protein into amyloid fibrils characteristic for PD, we investigated the effect of the presence of SARS-CoV-2 proteins on α-synuclein aggregation. We show, in test tube experiments, that SARS-CoV-2 spike protein (S-protein) has no effect on α-synuclein aggregation, while SARS-CoV-2 nucleocapsid protein (N-protein) considerably speeds up the aggregation process. We observe the formation of multiprotein complexes and eventually amyloid fibrils. Microinjection of N-protein in SH-SY5Y cells disturbed the α-synuclein proteostasis and increased cell death. Our results point toward direct interactions between the N-protein of SARS-CoV-2 and α-synuclein as molecular basis for the observed correlation between SARS-CoV-2 infections and Parkinsonism." @default.
- W3215083090 created "2021-12-06" @default.
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- W3215083090 date "2021-12-03" @default.
- W3215083090 modified "2023-10-14" @default.
- W3215083090 title "Interactions between SARS-CoV-2 N-Protein and α-Synuclein Accelerate Amyloid Formation" @default.
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- W3215083090 doi "https://doi.org/10.1021/acschemneuro.1c00666" @default.
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